Comparison of overall test performance among those with both CRP and PV performed simultaneously, N = 9575
| Disease outcomea | n | CRP AUCb (95% CI) | PV AUC (95% CI) | P-value for CRP versus PV | CRP and PV AUC (95% CI) | P-value for combined versus better single test |
|---|---|---|---|---|---|---|
| Any relevant disease | 817 | 0.672 (0.652 to 0.692) | 0.659 (0.640 to 0.679) | 0.170 | 0.686 (0.667 to 0.706) | 0.004 |
| Infection | 325 | 0.638 (0.608 to 0.670) | 0.597 (0.564 to 0.628) | 0.004 | 0.639 (0.608 to 0.669) | 0.280 |
| Autoimmune conditions | 338 | 0.687 (0.657 to 0.717) | 0.686 (0.655 to 0.717) | 0.970 | 0.709 (0.679 to 0.739) | 0.009 |
| Cancer | 183 | 0.753 (0.720 to 0.787) | 0.760 (0.726 to 0.793) | 0.490 | 0.764 (0.731 to 0.797) | 0.170 |
↵a Where disease subtypes were examined, diseases other than the specified condition reported were classified as non-diseased.
↵b AUC = area under the receiver operator curve, where AUC = 0.5 is equivalent to no diagnostic utility and AUC = 1 is perfect diagnostic accuracy. AUC was calculated using logistic regression modelling with test result(s) on a log scale and age and sex as additional explanatory variables. CRP = C-reactive protein. PV = plasma viscosity.