Table 4.

Comparison of overall test performance among those with both CRP and PV performed simultaneously, N = 9575

Disease outcomeanCRP AUCb (95% CI)PV AUC (95% CI)P-value for CRP versus PVCRP and PV AUC (95% CI)P-value for combined versus better single test
Any relevant disease8170.672 (0.652 to 0.692)0.659 (0.640 to 0.679)0.1700.686 (0.667 to 0.706)0.004
Infection3250.638 (0.608 to 0.670)0.597 (0.564 to 0.628)0.0040.639 (0.608 to 0.669)0.280
Autoimmune conditions3380.687 (0.657 to 0.717)0.686 (0.655 to 0.717)0.9700.709 (0.679 to 0.739)0.009
Cancer1830.753 (0.720 to 0.787)0.760 (0.726 to 0.793)0.4900.764 (0.731 to 0.797)0.170
  • a Where disease subtypes were examined, diseases other than the specified condition reported were classified as non-diseased.

  • b AUC = area under the receiver operator curve, where AUC = 0.5 is equivalent to no diagnostic utility and AUC = 1 is perfect diagnostic accuracy. AUC was calculated using logistic regression modelling with test result(s) on a log scale and age and sex as additional explanatory variables. CRP = C-reactive protein. PV = plasma viscosity.