Most frequent unique combination clusters for patients with MM2+, stratified by total number of chronic diseases and by sex
| Age group/Rankb | At least two chronic conditionsa | At least three chronic conditionsa | ||||||
|---|---|---|---|---|---|---|---|---|
| Female | Male | Female | Male | |||||
| Combinationc | n (%)d | Combinationc | n (%)d | Combinationc | n (%)d | Combinationc | n (%)d | |
| All ages, female: 113 209, male: 82 629 | ||||||||
| 1 | AD — OB | 3991 (3.5) | HT — OB | 3866 (4.7) | AD — MP — OB | 1621 (1.4) | HL — HT — OB | 1389 (1.7) |
| 2 | MP — OB | 3837 (3.4) | MP — OB | 3580 (4.3) | HT — MP — OB | 1019 (0.9) | DB — HT — OB | 1226 (1.5) |
| 3 | HT — OB | 3491 (3.1) | AD — OB | 2431 (2.9) | DB — HT — OB | 869 (0.8) | HT — MP — OB | 1061 (1.3) |
| 18–34 years; female: 11 507, male: 5959 | ||||||||
| 1 | AD — OB | 1197 (10.4) | AD — OB | 713 (12.0) | AD — MP — OB | 373 (3.2) | AD — MP — OB | 171 (2.9) |
| 2 | MP — OB | 817 (7.1) | MP — OB | 648 (10.9) | AD — CA — OB | 205 (1.8) | CA — MP — OB | 67 (1.1) |
| 3 | AD — MP | 608 (5.3) | AD — MP | 422 (7.1) | AD — COPDA — OB | 131 (1.1) | AD — CA — OB | 60 (1.0) |
| 35–44 years; female: 14 756, male: 9098 | ||||||||
| 1 | AD — OB | 1140 (7.7) | MP — OB | 932 (10.2) | AD — MP — OB | 483 (3.3) | AD — MP — OB | 241 (2.6) |
| 2 | MP — OB | 1034 (7.0) | AD — OB | 653 (7.2) | AD — CA — OB | 234 (1.6) | HT — MP — OB | 127 (1.4) |
| 3 | CA — OB | 654 (4.4) | HT — OB | 479 (5.3) | CA — MP — OB | 170 (1.2) | CA — MP — OB | 122 (1.3) |
| 45–64 years; female: 44 712, male: 34 856 | ||||||||
| 1 | MP — OB | 1693 (3.8) | HT — OB | 1999 (5.7) | AD — MP — OB | 680 (1.5) | HL — HT — OB | 785 (2.3) |
| 2 | HT — OB | 472 (1.1) | MP — OB | 1725 (4.9) | HT — MP — OB | 551 (1.2) | HT — MP — OB | 605 (1.7) |
| 3 | AD — OB | 404 (0.9.) | HL — OB | 1310 (3.8) | CA — MP — OB | 426 (1.0) | DB — HT — OB | 559 (1.6) |
| 65–84 years; female: 33 264, male: 27 430 | ||||||||
| 1 | HT — OB | 1181 (3.6) | HT — OB | 1092 (4.0) | DB — HT — OB | 427 (1.3) | DB — HT — OB | 536 (2.0) |
| 2 | DB — OB | 146 (0.4) | DB — OB | 678 (2.5) | HL — HT — OB | 386 (1.2) | HL — HT — OB | 468 (1.7) |
| 3 | CA — OB | 343 (1.0) | CA — OB | 377 (1.4) | HT — MP — OB | 292 (0.9) | CA — HT — OB | 262 (1.0) |
| ≥85 years; female: 8970, male: 5279 | ||||||||
| 1 | HT — OB | 212 (2.4) | CA — HT | 42 (0.8) | DB — HT — OB | 59 (0.7) | DB — HT — OB | 53 (1.0) |
| 2 | DE — HT | 151 (1.7) | HT — OB | 41 (0.8) | HT — OB — ORA | 54 (0.6) | CD — HT — OB | 38 (0.7) |
| 3 | CD — HT | 126 (1.4) | CD — HT | 36 (0.7) | CA — HT — OB | 53 (0.6) | CA — HT — OB | 29 (0.5) |
↵a Including data points where the time elapsing between chronic condition diagnoses was 0 days.
↵b Rank indicates that the combinations are listed in order of frequency (starting with most frequent).
↵c Combinations presented in alphabetical order.
↵d Proportion of age group. AD = Anxiety or Depression. CA = Cancer. CD = Cardiovascular Disease. COPDA = Chronic Obstructive Pulmonary Disease or Asthma. DB = Diabetes. DE = Dementia. HL = Hyperlipidemia. HT = Hypertension. MP = Musculoskeletal Problem. OB = Obesity. ORA = Osteoarthritis or Rheumatoid Arthritis. The hyphens between conditions are used to identify combinations (unordered patterns).