Table 2.

Antibiotic exposure in the 12 months before index antibiotic prescription (T₀) and response failure criteria

Antibiotic exposure	Response failure, number of children (%)
	Referral	Second prescription	Emergency department visit	Hospital admission	Death	Total
	None	494 (68.23)	268 (87.58)	209 (86.01)	78 (75.73)	1 (100)	1050 (76.25)
1	153 (21.13)	32 (10.46)	28 (11.52)	17 (16.50)	0	230 (16.70)
≥2 antibiotic courses	77 (10.64)	6 (1.96)	6 (2.47)	8 (7.77)	0	97 (7.04)
Total	724^a	306^b	243^c	103^d	1^e	1377

↵a Median days to referral (IQR) = 2 (0–7).
↵b Median days to second prescription (IQR) = 10 (7–13).
↵c Median days to emergency visit (IQR) = 2 (1–7).
↵d Median days to hospital admission (IQR) = 2 (1–9).
↵e Death occurred at day 5. IQR = interquartile range.