Most frequent unique permutation clusters for patients with MM2+, stratified by total number of chronic conditions and by sex
| Age group/Rankb | At least two chronic conditionsa | At least three chronic conditionsa | ||||||
|---|---|---|---|---|---|---|---|---|
| Female | Male | Female | Male | |||||
| Permutation c | n (%)d | Permutationc | n (%)d | Permutationc | n (%)d | Permutationc | n (%)d | |
| All ages; female: 47 381, male: 30 478 | ||||||||
| 1 | AD ➔ OB | 1160 (2.4) | MP ➔ OB | 1051 (3.5) | AD ➔ OB ➔ MP | 177 (0.4) | HT ➔ OB ➔ HL | 675 (2.2) |
| 2 | MP ➔ OB | 1094 (2.3) | HT ➔ OB | 1179 (3.9) | MP ➔ OB ➔ AD | 176 (0.4) | HT ➔ OB ➔ MP | 374 (1.2) |
| 3 | AD ➔ MP | 909 (1.9) | AD ➔ OB | 1132 (3..8) | AD ➔ MP ➔ OB | 161 (0.3) | DB ➔ OB ➔ HT | 365 (1.2) |
| 18–34 years; female: 5565, male: 2624 | ||||||||
| 1 | AD ➔ OB | 388 (7.0) | MP ➔ OB | 443 (16.9) | MP ➔ OB ➔ AD | 41 (0.7) | AD ➔ OB ➔ MP | 157 (6.0) |
| 2 | AD ➔ MP | 249 (4.5) | AD ➔ OB | 397 (15.1) | AD ➔ OB ➔ MP | 41 (0.7) | AD ➔ MP ➔ OB | 67 (3.0) |
| 3 | MP ➔ OB | 245 (4.4) | AD ➔ MP | 253 (9.7) | MP ➔ AD ➔ OB | 37 (0.7) | MP ➔ AD ➔ OB | 61 (2.3) |
| 35–44 years; female: 6747, male: 3583 | ||||||||
| 1 | AD ➔ OB | 327 (4.8) | MP ➔ OB | 497 (14..0) | AD ➔ MP ➔ OB | 57 (0.8) | AD ➔ OB ➔ MP | 203 (5.7) |
| 2 | MP ➔ OB | 318 (4.7) | AD ➔ OB | 333 (9.2) | AD ➔ OB ➔ MP | 51 (0.8) | MP ➔ OB ➔ AD | 115 (3.2) |
| 3 | AD ➔ MP | 256 (3.8) | MP ➔ AD | 330 (9.2) | MP ➔ OB ➔ AD | 48 (0.7) | MP ➔ AD ➔ OB | 76 (2.1) |
| 45–64 years; female: 18 426, male: 12 372 | ||||||||
| 1 | MP ➔ OB | 456 (2.5) | MP ➔ OB | 674 (5.4) | HT ➔ OB ➔ MP | 87 (0.5) | HT ➔ OB ➔ HL | 291 (2.4) |
| 2 | AD ➔ OB | 400 (2.2) | HT ➔ OB | 472 (3.8) | AD ➔ OB ➔ MP | 80 (0.4) | MP ➔ OB ➔ HL | 205 (1.7) |
| 3 | AD ➔ MP | 365 (2.0) | AD ➔ OB | 404 (3.3) | MP ➔ OB ➔ AD | 78 (0.4) | MP ➔ OB ➔ HT | 162 (1.3) |
| 65–84 years: female: 12 819, male: 9652 | ||||||||
| 1 | HT ➔ OB | 322 (2.5) | HT ➔ OB | 323 (3.3) | HT ➔ OB ➔ HL | 48 (0.4) | DB ➔ OB ➔ HT | 129 (1.3) |
| 2 | HT ➔ MP | 102 (0.8) | DB ➔ OB | 158 (1.7) | HT ➔ OB ➔ MP | 46 (0.4) | HT ➔ OB ➔ MP | 100 (1.0) |
| 3 | HT ➔ HL | 98 (0.8) | HT ➔ HL | 147 (1.6) | DB ➔ OB ➔ HT | 42 (0.3) | HT ➔ OB ➔ HL | 97 (1.0) |
| ≥85 years: female: 3824, male: 2247 | ||||||||
| 1 | HT ➔ OB | 62 (1.6) | HT ➔ OB | 76 (3.4) | HT ➔ OB ➔ ORA | 15 (0.4) | DB ➔ OB ➔ HT | 31 (1.4) |
| 2 | HT ➔ DE | 53 (1.4) | HT ➔ CA | 69 (3.1) | HT ➔ OB ➔ CA | 14 (0.4) | HT ➔ OB ➔ MP | 26 (1.2) |
| 3 | HT ➔ CD | 44 (1.2) | HT ➔ CD | 63 (2.9) | HT ➔ OB ➔ MP | 12 (0.3) | HT ➔ OB ➔ CA | 21 (1.0) |
↵a Excluding data points where the time elapsing between chronic condition diagnoses was zero days.
↵b Rank indicates that the permutations are listed in order of frequency (starting with most frequent).
↵c Permutations presented in temporal order.
↵d Proportion of age group and results representing <5 patients within age group supressed. AD = Anxiety or Depression. CA = Cancer. CD = Cardiovascular Disease. DB = Diabetes. DE = Dementia. HL = Hyperlipidemia. HT = Hypertension. MP = Musculoskeletal Problem. OB = Obesity. ORA = Osteoarthritis or Rheumatoid Arthritis. The arrows between conditions are used to identify permutations (ordered patterns).