Table 1.

Biochemical features of Paget’s disease of bone and other metabolic bone diseases

Disease	Serum calcium	Serum phosphate	Serum creatinine	Serum PTH	Serum 25(OH)D	Serum alkaline phosphatase
PHPT	^↑	^↓	^↔	^↑	^↔	^↔/↑
Osteomalacia	^↓	^↓	^↔	^↑	^↓↓	^↑
Paget’s	^↔	^↔	^↔	^↔	^↔	^↑/↑↑
CKD-MBD	^**/↓	^↑	^↑↑	^↑↑	^↔	^↑
Osteoporosis	^↔	^↔	^↔	^↔	^↔	^↔

↵CKD-MBD = chronic kidney disease — metabolic bone disease. PHPT = primary hyperparathyroidism. PTH = parathyroid hormone. ** = no change. ↑ = elevated. ↑↑ = markedly elevated. ↓ = reduced. ↔ = within reference range.