Disease | 1-year incidence of disease | Pre-existing disease | ||||
---|---|---|---|---|---|---|
TH (N= 39 850) n (%) | NPC (N= 9684) n (%) | RR (95% CI) | TH (N= 39 850) n (%) | NPC (N= 9684) n (%) | OR (95% CI) | |
Thromboembolic disease | 589 (1.5) | 114 (1.2) | 1.3 (1.0 to 1.5) P = 0.02 | 8943 (22.4) | 2325 (24.0) | 0.9 (0.9 to 1.0) P = 0.001 |
Ischaemic heart disease | 524 (1.3) | 113 (1.2) | 1.1 (0.9 to 1.4) P = 0.24 | 4816 (12.1) | 1144 (11.8) | 1.0 (1.0 to 1.1) P = 0.46 |
Inflammatory bowel disease | 386 (1.0) | 44 (0.5) | 2.1 (1.6 to 2.9) P<0.001 | 2232 (5.6) | 406 (4.2) | 1.4 (1.2 to 1.5) P<0.001 |
Iron-deficiency anaemia | 1811 (4.5) | 89 (0.9) | 4.9 (4.0 to 6.1) P<0.001 | 2055 (5.2) | 346 (3.6) | 1.5 (1.3 to 1.7) P<0.001 |
Rheumatoid arthritis | 370 (0.9) | 18 (0.2) | 5.0 (3.1 to 8.0) P<0.001 | 1479 (3.7) | 155 (1.6) | 2.4 (2.0 to 2.8) P<0.001 |
Giant cell arteritis | 866 (2.2) | 42 (0.4) | 5.0 (3.7 to 6.8) P<0.001 | 1253 (3.1) | 194 (2) | 1.6 (1.4 to 1.9) P<0.0001 |
Segmental colitis associated with diverticulosis | 136 (0.3) | 18 (0.2) | 1.8 (1.1 to 3.0) P = 0.01 | 950 (2.4) | 202 (2.0) | 1.1 (1.0 to 1.3) P = 0.08 |
Chronic obstructive pulmonary disease | 77 (0.2) | 11 (0.1) | 1.7 (0.9 to 3.2) P = 0.09 | 488 (1.2) | 62 (0.6) | 1.9 (1.5 to 2.6) P<0.001 |
Raynaud’s syndrome | 39 (0.1) | 4 (0.04) | P = 0.12 | 385 (1.0) | 83 (0.9) | P = 0.35 |
Coeliac disease | 75 (0.2) | 4 (0.04) | P<0.001 | 107 (0.3) | 34 (0.4) | P = 0.17 |
Othera | 34 (0.09) | 6 (0.06) | — | 211 (0.5) | 43 (0.4) | — |
At least one of the aboveb | 4579 (11.5) | 443 (4.6) | 2.5 (2.3 to 2.8) P<0.001 | 22 612 (56.7) | 4846 (50.0) | 1.3 (1.2 to 1.4) P<0.001 |
↵a Other includes ankylosing spondylitis, chronic hepatitis B, sarcoidosis, and granulomatosis with polyangiitis.
↵b The number of patients with at least one disease diagnosed. NPC = normal platelet count. OR = odds ratio. RR = risk ratio. TH = thrombocytosis. — = no statistical methods applied here due to the heterogeneity of the ‘other’ group.