Test result | All FIT brands, n= 15 789 | Actim Fecal Blood, n= 4232 | Analyz FOB, n= 7889 | Chemtrue FOB Test, n= 1756 | Diaquick FOB, n= 1751 | Diaquick FOB or Analyz FOB, n= 161 |
---|---|---|---|---|---|---|
Colorectal cancer, n | 304 | 79 | 158 | 29 | 38 | 0 |
True positive, n | 277 | 77 | 140 | 29 | 31 | 0 |
False negative, n | 27 | 2 | 18 | 0 | 7 | 0 |
False positive, n | 4298 | 1230 | 2090 | 593 | 352 | 33 |
True negative, n | 11 187 | 2923 | 5641 | 1134 | 1361 | 128 |
Sensitivity, % | 91.1 | 97.5 | 88.6 | 100 | 81.6 | n/a |
Specificity, % | 72.2 | 70.4 | 73.0 | 65.7 | 79.5 | 79.5 |
PPV (95% CI) | 6.1 (5.4 to 6.8) | 5.9 (4.6 to 7.2) | 6.3 (5.3 to 7.3) | 4.7 (3.0 to 6.3) | 8.1 (5.4 to 10.8) | n/a |
NPV (95% CI) | 99.8 (99.7 to 99.8) | 99.9 (99.8 to 100) | 99.7 (99.5 to 99.8) | 100 (99.7 to 100) | 99.5 (99.1 to 99.9) | 100 (97.2 to 100) |
LR+ | 3.28 | 3.29 | 3.28 | 2.92 | 3.98 | n/a |
LR– | 0.12 | 0.04 | 0.16 | 0 | 0.23 | n/a |
CRC = colorectal cancer. FIT = faecal immunochemical test. LR− = negative likelihood ratio. LR+ = positive likelihood ratio. n/a = not available. NPV = negative predictive value.
PPV = positive predictive value.