Effectiveness of the study intervention: proportion of patients with anxiety during the studya
| Variable | Intervention group (n= 1484, %) (95% CI) | Control group (n= 1514, %) (95% CI) | Absolute difference % points (95% CI) | P-value |
|---|---|---|---|---|
| Primary analysis | ||||
| Anxiety at 18 months | 10.43 (8.73 to 12.13) | 13.10 (11.4 to 14.79) | −2.67 (−5.05 to −0.28) | 0.029 |
| Secondary analysis | ||||
| Anxiety at 6 months | 4.55 (3.16 to 5.95) | 5.18 (4.04 to 6.32) | −0.63 (−2.43 to 1.17) | 0.492 |
| Anxiety at 12 months | 7.99 (6.43 to 9.55) | 9.56 (8.14 to 10.98) | −1.57 (−3.67 to 0.54) | 0.145 |
| Sensitivity analysis | ||||
| Anxiety at 18 months, unadjusted | 10.69 (8.91 to 12.46) | 12.83 (10.88 to 14.79) | −2.14 (−4.78 to 0.50) | 0.112 |
| Anxiety at 18 months, adjusted for all unbalanced variablesb | 10.36 (8.81 to 11.91) | 13.14 (11.62 to 14.67) | −2.78 (−4.95 to −0.62) | 0.012 |
↵a Displays standardised probabilities or predicted margins estimated using generalised estimating equations including an exchangeable correlation structure and robust standard errors for clustering on centre and adjusted for baseline probability of depression.
↵b Adjusted for baseline probability of depression, the other unbalanced baseline variables not included in the predictD-Spain risk algorithm (employment status, owner/occupier of an accommodation, perception of safety inside/outside the home, and experiences of discrimination), GPs’ familiarity and ease in their relationships with mental health teams, social workers, nurses, and use of antidepressants, and city. CI = confidence interval.