Table 3.

Adjusted Cox regression outputs for 28-day and 1-year mortality

Characteristic^a	28-day mortality			1-year mortality

	HR	95% CI	P-value	HR	95% CI	P-value
Age, years	1.06	1.06 to 1.07	<0.001	1.06	1.05 to 1.06	<0.001

Sex, female	1.00	0.93 to 1.09	>0.90	0.87	0.83 to 0.91	<0.001

Lymphocyte count, × 10⁹ cells/L
0–1	1.63	1.44 to 1.84	<0.001	1.59	1.48 to 1.71	<0.001
2–3	ref	ref	—	ref	ref	—
1–2	1.15	1.03 to 1.27	0.009	1.14	1.08 to 1.21	<0.001
>3	0.95	0.78 to 1.15	0.6	0.91	0.82 to 1.01	0.069

Comorbidities
Diabetes	0.99	0.89 to 1.11	0.90	1.07	1.01 to 1.14	0.027
Ischaemic heart disease	0.82	0.74 to 0.90	<0.001	0.98	0.93 to 1.03	0.40
Ischaemic stroke	1.40	1.28 to 1.54	<0.001	1.29	1.22 to 1.36	<0.001
Peripheral vascular disease	0.95	0.81 to 1.13	0.60	1.08	0.99 to 1.18	0.081
Alcohol excess	1.52	1.15 to 2.02	0.004	1.32	1.13 to 1.55	<0.001
Autoimmunity	0.87	0.77 to 0.97	0.010	0.92	0.87 to 0.98	0.005
Solid organ transplant	0.97	0.40 to 2.33	>0.90	1.14	0.76 to 1.70	0.50
Cancer (solid organ)	2.86	2.52 to 3.23	<0.001	2.98	2.77 to 3.20	<0.001
Haematological cancer	0.95	0.64 to 1.41	0.80	1.73	1.46 to 2.06	<0.001
Corticosteroid user	1.12	1.00 to 1.26	0.053	1.36	1.28 to 1.44	<0.001

Smoking status
Never smoker	ref	ref	—	ref	ref	—
Ex-smoker	0.97	0.87 to 1.08	0.50	1.05	0.99 to 1.12	0.12
Current smoker	1.42	1.20 to 1.67	<0.001	1.48	1.35 to 1.62	<0.001
Unknown	1.43	1.28 to 1.60	<0.001	1.25	1.17 to 1.34	<0.001

Calendar year	0.95	0.94 to 0.96	<0.001	0.97	0.96 to 0.97	<0.001

↵a HIV status and stem cell transplant removed as few instances; Index of Multiple Deprivation not shown for brevity. HR = hazard ratio.