Pooled sensitivity time POS, % (95% CI) | |||||
---|---|---|---|---|---|
Ig class | Week 1 (days 1–7) | Week 2 (days 8–14) | Week 3 (days 15–21) | Week 3 onwards (days 22–35) | Day 35+ |
IgG | 29.7 (22.1 to 38.6) | 66.5 (57.9 to 74.2) | 88.2 (83.5 to 91.8) | 80.3 (72.4 to 86.4) | 86.7 (79.6 to 91.7) |
IgM | 23.2 (14.9 to 34.2) | 58.4 (45.5 to 70.3) | 75.4 (64.3 to 83.8) | 68.1 (55.0 to 78.9) | 53.9 (38.4 to 68.6) |
IgA | 28.4 (0.9 to 94.3) | 78.1 (9.5 to 99.2) | 98.7 (39.0 to 100) | 98.7 (91.9 to 99.8) | 100 (85.2 to 100) |
IgG/IgM | 30.1 (21.4 to 40.7) | 72.2 (63.5 to 79.5) | 91.4 (87.0 to 94.4) | 96.0 (90.6 to 98.3) | 77.7 (66.0 to 86.2) |
IgA/IgG | 0 (0 to 26.5) | 50.0 (18.7 to 81.3) | 87.5 (47.3 to 99.6) | 100 (2.5 to 100) | N/R |
Total antibodies | 24.5 (9.5 to 50.0) | 84.0 (64.1 to 93.9) | 98.1 (90.1 to 99.6) | 69.5 (34.8 to 90.7) | 79.0 (49.8 to 93.4) |
↵a Total antibody refers to detection of all anti-SARS-CoV-2 isotypes, including primarily IgG, IgM, and IgA without the capacity to distinguish between said isotypes. If either isotype of a combination (IgG/IgM or IgA/IgG) was detected, a positive result was detected. No data were reported for IgA/IgM. Adapted from Deeks et al .14 CI = confidence interval. Ig = immunoglobulin. N/R = not reported. POS = post-onset of symptoms.