Table 4.

Association of clinical variables with weight change: subgroup analysis according to baseline diabetes, hypertension and lipid status

SubgroupVariableChange in outcome per kg weight change (95% CI)P-value
HypertensionSBP, mmHg0.5 (0.36 to 0.60)<0.001a
DBP, mmHg0.4 (0.29 to 0.43)<0.001a
No hypertensionSBP, mmHg0.3 (0.27 to 0.42)<0.001a
DBP, mmHg0.3 (0.26 to 0.36)<0.001a
DiabetesHbA1c, mmol/mol0.6 (0.35 to 0.79)<0.001a
Glucose, mmol/l0.07 (0.03 to 0.12)0.002a
No diabetesHbA1c, mmol/mol0.1 (0.09 to 0.14)<0.001a
Glucose, mmol/l0.02 (0.01 to 0.02)<0.001a
Abnormal plasma lipidsTotal cholesterol, mmol/l0.02 (0.01 to 0.02)<0.001a
HDL, mmol/l−0.006 (−0.01 to −0.0003)0.037a
LDL, mmol/l0.01 (0.005 to 0.02)0.002a
Triglycerides, mmol/l0.04 (0.03 to 0.05)<0.001a
Normal plasma lipidsTotal cholesterol, mmol/l0.02 (0.01 to 0.03)<0.001a
HDL, mmol/l−0.003 (−0.006 to −0.0003)0.028a
LDL, mmol/l0.01 (0.002 to 0.02)0.011a
Triglycerides, mmol/l0.02 (0.01 to 0.02)<0.001a
  • a Statistically significant change at P<0.05. DBP = diastolic blood pressure. HbA1c = glycated haemoglobin.

  • HDL = high-density lipoprotein. LDL = low-density lipoprotein. SBP = systolic blood pressure.