Examples of average predicted changes in blood pressure and glycaemic control with weight change
| Variable | Example: variable change for X kg weight change | Variable change for every 5 kg weight change | Variable change for every 10 kg weight change |
|---|---|---|---|
| SBP (all patients) | 2 mmHg (1.6 to 2.2 mmHg) SBP change for 5 kg weight change | 2 mmHg (1.6 to 2.2 mmHg) SBP change for 5 kg weight change | 4 mmHg (3.2 to 4.5 mmHg) SBP change for 10 kg weight change |
| SBP (hypertensive subgroup) | 1 mmHg (0.8 to 1.2 mmHg) SBP change for every 2 kg weight change | 2 mmHg (1.8 to 3.0 mmHg) SBP change for 5 kg weight change | 5 mmHg (3.6 to 6.0 mmHg) SBP change for 10 kg weight change |
| DBP (all patients) | 3 mmHg (2.9 to 3.7 mmHg) DBP change for 10 kg weight change | 1.5 mmHg (1.4 to 1.8 mmHg) DBP change for 5 kg weight change | 3 mmHg (2.9 to 3.7 mmHg) DBP change for 10 kg weight change |
| DBP (hypertensive subgroup) | 2 mmHg (1.4 to 2.2 mmHg) DBP change for 5 kg weight change | 2 mmHg (1.4 to 2.2 mmHg) DBP change for 5 kg weight change | 4 mmHg (2.9 to 4.3 mmHg) DBP change for 10 kg weight change |
| HbA1c (all patients) | 1 mmol/mol (0.7 to 1.1 mmol/mol) HbA1c change for 5 kg weight change | 1 mmol/mol (0.7 to 1.1 mmol/mol) HbA1c change for 5 kg weight change | 2 mmol/mol (1.3 to 2.2 mmol/mol) HbA1c change for 10 kg weight change |
| HbA1c (diabetic subgroup) | 3 mmol/mol (1.8 to 4.0 mmol/mol) HbA1c change for 5 kg weight change | 3 mmol/mol (1.8 to 4.0 mmol/mol) HbA1c change for 5 kg weight change | 6 mmol/mol (3.5 to 8.0 mmol/mol) HbA1c change for 10 kg weight change |
| Glucose (all patients) | 0.2 mmol (0.1 to 0.2 mmol) glucose change for 10 kg weight change | 0.1 mmol (0.1 to 0.1 mmol) glucose change for 5 kg weight change | 0.2 mmol (0.1 to 0.3 mmol glucose change for 10 kg weight change |
| Glucose (diabetic subgroup) | 0.6 mmol (0.2 to 1.0 mmol) glucose change for 8 kg weight change | 0.4 mmol (0.1 to 0.6 mmol) glucose change for 5 kg weight change | 0.7 mmol (0.3 to 1.2 mmol) glucose change for 10 kg weight change |
DBP = diastolic blood pressure. HbA1c = glycated haemoglobin. SBP = systolic blood pressure.