Adjusted multiple linear regression intention to treat and per protocol of primary outcomes using complete case analyses exploring the interaction with age (<65 versus ≥65) and number of conditions (<4 versus ≥4)
| Outcome | Intention to treat | Per protocol | ||||||
|---|---|---|---|---|---|---|---|---|
| Immediate follow-up | 6-month follow-up | Immediate follow-up | 6-month follow-up | |||||
| Mean difference (95% CI) | P-valuea | Mean difference (95% CI) | P-valuea | Mean difference (95% CI) | P-valuea | Mean difference (95% CI) | P-valuea | |
| Age, years | ||||||||
| EQ-VAS | ||||||||
| Age (<65 versus ≥65)b | 11.47 (−3.23 to 26.18) | 0.125 | 25.39 (6.81 to 43.98) | 0.008 | 8.49 (−6.72 to 23.70) | 0.270 | (3.19 to 43.06) 23.13 | 0.024 |
| FAI | ||||||||
| Age (<65 versus ≥65)c | 6.13 (1.93 to 10.34) | 0.005 | 4.74 (−0.53 to 10.01) | 0.077 | 4.90 (1.49 to 8.30) | 0.005 | 4.98 (−0.34 to 10.30) | 0.066 |
| Number of conditions | ||||||||
| EQ-VAS | ||||||||
| Conditions (<4 versus ≥4)d | −2.68 (−17.25 to 11.88) | 0.716 | −5.57 (−25.01 to 13.88) | 0.570 | −3.10 (−18.04 to 11.82) | 0.681 | −3.01 (−23.94 to 17.93) | 0.775 |
| FAI | ||||||||
| Conditions (<4 versus ≥4)e | −3.45 (−7.84 to 0.95) | 0.123 | −0.74 (−6.07 to 4.60) | 0.785 | −3.48 (−8.15 to 1.18) | 0.141 | −0.55 (−5.91 to 4.81) | 0.839 |
↵a P-values ≤0.05 are shown in bold.
↵b Adjusted for sex, baseline EQ-VAS, area, and number of conditions at baseline.
↵c Adjusted for sex, baseline FAI total, area, and number of conditions at baseline.
↵d Adjusted for sex, baseline EQ-VAS, area, and age.
↵e Adjusted for sex, baseline FAI total, area, and age. EQ-VAS = EQ visual analogue scale. FAI = Frenchay Activities Index.