Characteristic | QResearch derivation cohort, n (%)a | QResearch validation cohort, n (%)a | CPRD validation cohort, n (%)a |
---|---|---|---|
Total number of men, n | 844 455 | 292 084 | 316 583 |
Median age, years (IQR) | 57 (48–67) | 57 (48–67) | 58 (49–67) |
Level of deprivation, mean Townsend score (SD) | −0.5 (3.1) | −0.4 (3.1) | −1.2 (3.0) |
Age group, years | |||
25–49 | 244 480 (29.0) | 83 294 (28.5) | 85 087 (26.9) |
50–59 | 225 655 (26.7) | 79 029 (27.1) | 89 633 (28.3) |
60–69 | 211 355 (25.0) | 72 989 (25.0) | 81 253 (25.7) |
70–84 | 162 965 (19.3) | 56 772 (19.4) | 60 610 (19.1) |
Ethnic group | |||
Ethnicity recorded | 661 354 (78.3) | 228 664 (78.3) | 155 947 (49.3) |
White/not recorded | 763 692 (90.4) | 264 163 (90.4) | 305 087 (96.4) |
Indian | 15 883 (1.9) | 5428 (1.9) | 2693 (0.9) |
Pakistani | 9501 (1.1) | 3087 (1.1) | 1012 (0.3) |
Bangladeshi | 4875 (0.6) | 2003 (0.7) | 254 (0.1) |
Other Asian | 8388 (1.0) | 2642 (0.9) | 1311 (0.4) |
Black Caribbean | 13 198 (1.6) | 4354 (1.5) | 1644 (0.5) |
Black African | 12 631 (1.5) | 4704 (1.6) | 1750 (0.6) |
Chinese | 1968 (0.2) | 667 (0.2) | 293 (0.1) |
Other ethnic group | 14 319 (1.7) | 5036 (1.7) | 2539 (0.8) |
Smoking status | |||
Smoking status recorded | 839 482 (99.4) | 290 479 (99.5) | 314 742 (99.4) |
Non-smoker | 421 809 (50.0) | 144 973 (49.6) | 132 363 (41.8) |
Ex-smoker | 250 843 (29.7) | 86 556 (29.6) | 78 345 (24.7) |
Light smoker (1–9/day) | 96 515 (11.4) | 34 647 (11.9) | 51 075 (16.1) |
Moderate smoker (10–19/day) | 36 412 (4.3) | 12 709 (4.4) | 30 271 (9.6) |
Heavy smoker (≥20/day) | 33 903 (4.0) | 11 594 (4.0) | 22 688 (7.2) |
Medical history | |||
Median PSA level, score (IQR) | 1.18 (1.82) | 1.16 (1.76) | 1.22 (2.09) |
BMI recorded | 672 319 (79.6) | 234 612 (80.3) | 237 333 (75.0) |
Mean BMI, kg/m2 (SD) | 27.2 (4.4) | 27.2 (4.4) | 26.7 (4.0) |
Family history of prostate cancer | 8881 (1.1) | 2884 (1.0) | 1999 (0.6) |
Serious mental illness | 6475 (0.8) | 2386 (0.8) | 1946 (0.6) |
Type 1 diabetes | 2652 (0.3) | 890 (0.3) | 849 (0.3) |
Type 2 diabetes | 65 406 (7.7) | 23 070 (7.9) | 18 512 (5.8) |
↵a Unless otherwise stated. BMI = body mass index. CPRD = Clinical Practice Research Datalink. IQR = interquartile range. PSA = prostate specific antigen. SD = standard deviation.