Box 1.

List of extracted information

  • Methods: study authors, location, study design, and duration of follow-up

  • Participants: n, age (mean/median, range/SD), number of documented previous UTIs, recent antibiotic use, and whether currently pregnant

  • Interventions: methenamine hippurate

  • Comparators: placebo/no treatment or any antibiotic

  • Primary and secondary outcomes: UTI symptoms, adverse events (such as nausea, diarrhoea, rash, or any symptoms reported as an adverse event by the trial author), bacteriuria, antibiotic use, and antibiotic resistance

  • SD = standard deviation. UTI = urinary tract infection.