Results of primary analysis (n = 649) and secondary analyses in the FORM-2C cohort stratified by pre-baseline eGFR (n = 641), and separately stratified by age at baseline (n = 649)
| Stratum | n | c-statistic for eGFR-serum creatinine (95% CI) | c-statistic for eGFR-serum cystatin C (95% CI) | Difference in c-statisticsa (95% CI) |
|---|---|---|---|---|
| All participants (primary analysis) | 649 | 0.495 (0.471 to 0.519) | 0.497 (0.468 to 0.525) | −0.00157 (−0.0358 to 0.0273) |
| Pre-baseline eGFR ≥60 and <90 ml/min/1.73 m2 | 450 | 0.492 (0.462 to 0.522) | 0.530 (0.500 to 0.563) | −0.0379 (−0.0760 to 0.00289) |
| Pre-baseline eGFR ≥30 and <60 ml/min/1.73 m2 | 191 | 0.491 (0.442 to 0.540) | 0.412 (0.371 to 0.469) | 0.0789 (0.0178 to 0.145) |
| Aged<75 years | 453 | 0.502 (0.473 to 0.529) | 0.516 (0.484 to 0.546) | −0.0135 (−0.0492 to 0.0257) |
| Aged ≥75 years | 196 | 0.496 (0.452 to 0.543) | 0.448 (0.402 to 0.499) | 0.0478 (−0.0135 to 0.109) |
↵a Serum creatinine minus serum cystatin C. eGFR = estimated glomerular filtration rate. FORM-2C = Frequency of Renal Monitoring — Creatinine and Cystatin C.