Diagnostic accuracy measures with 95% confidence intervals of the simplified prediction model for predicting sepsis at different score thresholds in development data, N = 357
| Cut-off point, (n) | Sensitivity (95% CI) | Specificity (95% CI) | LR+ (95% CI) | LR–(95% CI) | PPV (95% CI) | NPV (95% CI) |
|---|---|---|---|---|---|---|
| ≥1 (352) | 100 (98 to 100) | 2.4 (0.8 to 5.6) | 1.02 (1.00 to 1.05) | 0.00 | 43 (38 to 48) | 100 |
| ≥2 (324) | 99 (96 to 100) | 16 (11 to 21) | 1.18 (1.11 to 1.25) | 0.04 (0.01 to 0.31) | 46 (41 to 52) | 97 (84 to 100) |
| ≥3 (251) | 92 (87 to 96) | 46 (39 to 53) | 1.69 (1.48 to 1.93) | 0.17 (0.10 to 0.31) | 55 (49 to 62) | 89 (81 to 94) |
| ≥4 (118) | 60 (51 to 68) | 86 (81 to 91) | 4.39 (3.03 to 6.34) | 0.47 (0.38 to 0.57) | 76 (68 to 84) | 74 (68 to 80) |
| ≥5 (32) | 18 (12 to 25) | 98 (94 to 99) | 7.37 (2.90 to 18.7) | 0.84 (0.78 to 0.91) | 84 (67 to 95) | 62 (56 to 67) |
LR+ = positive likelihood ratio. LR–= negative likelihood ratio. PPV = positive predictive value. NPV = negative predictive value.