Author (year, location) | RCT design | Follow-up | Randomised, n | Age, years, mean (SD) | Intervention | Pharmacotherapy regimen | Comparator: modality and dose |
---|---|---|---|---|---|---|---|
Abrutyn (1994, US)28 | Parallel quasi-RCT | 9 years | 358 | Intervention: 81.8 Control: 82 | Trimethoprim (oral) Norfloxacin (oral) | 200 mg twice a day for 14 days 400 mg twice a day for 14 days | Placebo, one tablet twice a day for 14 days |
Abrutyn (1996, US)27 | Parallel quasi-RCT | 9 years | 358 | Intervention: 82 C: 81 | Not specified | Not specified | Placebo, one tablet twice a day for 14 days |
Boscia (1987, US)29 | RCT | 2 years | 124 | Intervention: 85.8 (0.9) Control: 85.8 (0.7) | Initial therapy: trimethoprim or cefaclor (oral) Re-treatment: trimethoprim or cefaclor (oral) | Trimethoprim: 200 mg as a single dose Cefaclor: 500 mg three times a day for 3 days Trimethoprim: 200 mg twice a day for 14 days Cefaclor: 500 mg three times a day for 14 days | No therapy |
Giamarellou (1998, Greece)23 | Open-label RCT | 1 year | 136 | Intervention 1: 84.5 (6.1) Intervention 2: 82.8 (5.2) Control: 82.9 (6.1) | Ofloxacin (oral) | Intervention 1: 200 mg twice a day for 3 days then daily for 12 weeks Intervention 2: 200 mg twice a day for 3 days, fortnightly for 12 weeks | No therapy |
Giamarellou (2007, Greece)24 | Open-label RCT | 3 months | 132 | Intervention 1: 84.5 (6.1) Intervention 2: 82.8 (5.2) Control: 82.9 (6.1) | Ofloxacin (oral) | Intervention 1: 200 mg twice a day for 3 days then daily for 12 weeks Intervention 2: 200 mg twice a day for 3 days, fortnightly for 12 weeks | No therapy |
Nicolle(1983, Canada)30 | RCT | 2 years | 36 | Intervention: 80.4 (12.1) Control: 80.7 (9.6) | Trimethoprim/sulfamethoxazole (oral) or tobramycin (IV) Tobramycin (IM): 1.5 mg/kg three times a day for 2 weeks | Trimethoprim/sulfamethoxazole: 160 mg/800 mg for 2 weeks | No therapy |
Nicolle(1987, Canada)31 | RCT | 1 year | 52 | Intervention: 83.3 (8.7) Control: 83.6 (9) | Trimethoprim/sulfamethoxazole (oral) or tobramycin (IV) | Not specified | No therapy |
Staszewska-Pistoni (1994, Greece)25 | RCT | 5 years | 102 | Intervention: 82.7 Control: 82.6 | Netilmicin (IM) Co-trimoxazole (IM) Ceforanide (IM) | Netilmicin: 150 mg daily for 10 days Co-trimoxazole: 160/800 mg daily for 10 days Ceforanide: 1 g daily for 10 days | No therapy |
Staszeweska-Pistoni (1995, Greece)26 | RCT | 3 months | 93 | Intervention 1: 84.5 Intervention 2: 82.8 Control: 82.8 | Ofloxacin (oral) | 200 mg twice a day for 3 days, then Intervention 1: daily for 87 days Intervention 2: 3 days every fortnight for 3 months | No therapy |
↵a Total number of participants randomised across the nine studies = 1391. IM = intramuscular. IV = intravenous. RCT = randomised controlled trial.