The significance of genetic factors in the etiology of schizophrenia: Results from the national study of adoptees in Denmark☆
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2012, Schizophrenia ResearchCitation Excerpt :Both SZ and BP disorders are debilitating psychiatric illnesses that pose a major burden on public health due to early onset and for many patients, the need for long-term care. While the etiology of these disorders is still unknown, in conjunction with environmental and developmental factors (Kendler et al., 1985; Kety, 1987; Jablensky et al., 1992a, 1992b; Kendler and Diehl, 1993a, 1993b; Kendler et al., 1994a, 1994b; Kendler KS, 1996; Hansen et al., 2007b) there is consistent evidence for a substantial genetic component (Sullivan et al., 2003; Kato et al., 2005) (heritability ~ 80%) with some shared between both diseases (Berrettini, 2003; Purcell et al., 2009a). GWAS are a powerful, systematic and unbiased genetic approach to study the common disease/common variant (CDCV) hypothesis of complex disorders like schizophrenia.
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Presented at the Symposium of Genetic Research in Psychiatry, Berlin, 27 September 1986.