Elsevier

Preventive Medicine

Volume 14, Issue 3, May 1985, Pages 272-278
Preventive Medicine

WHO European collaborative trial of multifactorial prevention of coronary heart disease

https://doi.org/10.1016/0091-7435(85)90056-8Get rights and content

Abstract

Results are reported from a trial of multifactorial prevention of coronary heart disease (CHD) in occupational groups, involving randomization of 66 factories to intervention and control (49,781 men ages 40 to 59) in the United Kingdom, Belgium, Italy, and Poland. Net average reductions in the intervention factors were 1.2% (plasma cholesterol), 8.9% (daily cigarettes), 0.4% (weight), 2% (systolic blood pressure), and 11% for a combined risk estimate. Reductions were larger in high-risk men (19% for the combined estimate). Red blood cell fatty acid profiles were substantially changed. There was a net overall reduction of 7.4% in fatal CHD and 2.7% in total deaths. Benefits were larger in centers achieving larger risk factor reductions, and in one country—Belgium—the net decreases in CHD incidence and total deaths were significant at the 5% level. Benefit was at least as great in men with established ECG abnormality. It is concluded that CHD risk in middle-aged men seems to be reducible by simple and cost-effective means.

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Members of the Group—Belgium: Dr. G. De Backer, Dr. M. Kornitzer, Professor C. Thilly (Data Coordinator); Italy: Professor A. Menotti, Professor G. Ricci, Professor G. C. Urbinati, Professor G. Farchi; Poland: Professor S. L. Rywik, Professor J. Sznajd, Professor W. B. Szostak, Dr. M. Magdon, Dr. J. Charzewska; Spain: Professor I. Balaguer-Vintro, Dr. L. Thomas-Abadal, Dr. S. Sans, Dr. A. Domingo; United Kingdom: Professor G. Rose (Chairman), Professor H. D. Tunstall-Pedoe, Dr. R. F. Heller; World Health Organization (European Office): Dr. G. Lamm, Dr. V. P. Zaitsev.

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