Editorial rumination
The inadequacy of binary models for the clinical reality of three-zone diagnostic decisions

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Supported in part by a Grant from the Andrew W. Mellon Foundation.

Professor of Medicine and Epidemiology; Director, Clinical Epidemiology Unit and The Robert Wood Johnson Clinical Scholars Program, Yale University School of Medicine, New Haven, Connecticut, Senior Biostatistician, Cooperative Studies Program Coordinating Center, Veterans Administration Medical Center, West Haven, Connecticut.

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