Trial DesignInternational longitudinal registry of patients with atrial fibrillation at risk of stroke: Global Anticoagulant Registry in the FIELD (GARFIELD)
Section snippets
Registry design
The GARFIELD registry is an observational, multicenter, international prospective study of men and women with newly diagnosed AF and at least one additional risk factor for stroke. The aim is to enroll 55,000 patients at more than 1,000 centers in 50 countries.
Enrollment will take place in five independent, sequential, prospective cohorts (Figure 1). For the first cohort, the aim is to enroll 10,000 patients at 500 active sites in 19 countries (Australia, Austria, Brazil, Canada, China,
Discussion
The GARFIELD registry will describe the management and clinical outcomes of a cross section of patients with AF in real-life practice. Data will be collected from newly diagnosed patients with AF irrespective of whether they receive any intervention and will offer insights into treatment failure in patients who have, or who should have, commenced anticoagulant therapy or other pharmacologic treatment to prevent stroke. Patients in whom anticoagulant therapy would be appropriate but is not
Summary
The GARFIELD registry will provide unique and valuable insights into real-life treatment-initiation strategies, and the long-term clinical management and related outcomes of AF patients throughout the world. The inclusion of consecutive, treatment-naive patients with newly diagnosed non-valvular AF, irrespective of age and comorbidities or whether they receive anticoagulant therapy, will provide a representative perspective of AF management in unselected patient populations and across the
Acknowledgements
We thank the physicians, nurses, and patients involved in the GARFIELD registry.
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Registry number: TRI08888.
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For the GARFIELD Registry Investigators. See online Appendix A for complete listing.