Lower extremity peripheral artery disease in the absence of traditional risk factors. The Multi-Ethnic Study of Atherosclerosis
Section snippets
MESA population
MESA was initiated by the National Heart, Lung and Blood Institute, to investigate the prevalence, correlates, and progression of subclinical CVD in a multi-ethnic population-based sample of 6814 men and women aged 45–84 years without clinical CVD [13]. Participants were selected between 2000 and 2002 from six US field centers: Baltimore City and County, MD; Chicago, IL; Forsyth County, NC; Los Angeles County, CA; Northern Manhattan and the Bronx, NY; and St. Paul, MN. The Institutional Review
Results
Among the 6814 men and women free of clinical CVD enrolled in the MESA, 1932 (781 men and 1151 women) were selected for this analysis, in the absence of any of the 4 traditional risk factors. This low CVD-risk group included 841 non-Hispanic whites (43.5%), 388 African Americans (20%), 400 Hispanics (20.7%) and 303 Chinese Americans (15.6%). The mean estimated Framingham risk score of all CHD was 6.1%. In this low CVD-risk group, a low ABI (<1.0) was found in 176 cases (9.0%) and a high ABI was
Discussion
This study confirms that even in a population free of any clinical CVD and without traditional CVD risk factors, a significant proportion of the population has subclinical LE-PAD, defined by abnormal ABI values. In our pre-selected low-risk sub-sample of the MESA baseline cohort, a low ABI (<1.00) was found in 9% of participants, and additionally 7.8% of participants had an elevated (>1.30) ABI. Almost one-fifth of the MESA participants with low (<1.00) ABI had no traditional CVD risk factors
Acknowledgments
This research was supported by contracts N01-HC-95159 through N01-HC-95169 from the National Heart, Lung, and Blood Institute. The authors thank the other investigators, the staff, and the participants of the MESA study for their valuable contributions. A full list of participating MESA investigators and institutions can be found at http://www.mesa-nhlbi.org.
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