Archival ReportDefault-Mode and Task-Positive Network Activity in Major Depressive Disorder: Implications for Adaptive and Maladaptive Rumination
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Participants
Seventeen adults diagnosed with MDD and 17 control (CTL) participants with no history of any DSM-IV psychiatric disorder participated in this study. All depressed participants met criteria for a DSM-IV diagnosis of MDD based on their responses to the Structured Clinical Interview for DSM-III-R Personality Disorders (24) as administered by trained diagnostic staff; none of the CTL participants met diagnostic criteria for any current or past Axis I disorder. Depressed individuals taking
Demographic and Clinical Variables
Demographic and clinical characteristics of the depressed and nondepressed participants are presented in Table 2; case-by-case demographic and clinical data for participants in the MDD group are presented in Table 3. The two groups of participants did not differ significantly in age, t(32) = .84, or gender composition, χ2(32) = .0, both p > .10. As expected, the depressed participants had higher scores on the BDI-II, HAM-D, RRS-D, RRS-B, and RRS-R than did the nondepressed participants, t(32) =
Discussion
In the present study, we examined the relative dominance of DMN over TPN and its association with adaptive and maladaptive rumination in major depression. In addition, we examined RFIC responding during initiations of ascent in the DMN and the TPN in depressed and in never-disordered participants. We found that increasing levels of DMN dominance in depression were associated with higher levels of maladaptive, depressive rumination and lower levels of adaptive, reflective rumination. Further,
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