Abstract
Psychophysiological data support the concept that migraine is the result of cortical hypersensitivity, hyperactivity, and a lack of habituation. There is evidence that this is a brain-stem related information processing dysfunction. This cortical activity reflects a periodicity between 2 migraine attacks and it may be due to endogenous or exogenous factors. In the few days preceding the next attack slow cortical potentials are highest and habituation delay experimentally recorded during contingent negative variation is at a maximum. These striking features of slow cortical potentials are predictors of the next attack. The pronounced negativity can be fed back to the patient. The data support the hypothesis that a change in amplitudes of slow cortical potentials is caused by altered habituation during the recording session. This kind of neurofeedback can be characterized as “empirically based” because it improves habituation and it proves to be clinically efficient.
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REFERENCES
Ahmed, I. (1999). Contingent negative variation in migraine: Effect of beta blocker therapy. Clinical Encephalography, 30, 21–23.
Anokhin, A. P., Birbaumer, N., Lutzenberger, W., Nikolaev, A., & Vogel, F. (1996). Age increases brain complexity. Electroencephalography and Clinical Neurophysiology, 99, 63–68.
Aurora, S. K., Ahmad, B. K., Welch, K. M. A., Bhardhwaj, P., & Ramadan, N. M. (1998). Transkranial magnetic stimulation confirms hyperexcitability of occipital cortex in migraine. Neurology, 50, 1111–1114.
Brody, S., Rau, H., Köhler, F., Schupp, H., Lutzenberger, W., & Birbaumer, N. (1994). Slow cortical potential biofeedback and the startle reflex. Biofeedback and Self-Regulation, 19, 1–11.
Elbert, T. (1993). Slow cortical potentials reflect the regulation of cortical excitability. In W. C. McCallum & H. Curry (Eds.), Slow potentials in the human brain (pp. 235–252). New York: Plenum.
Evers, S., Quibelday, F., Grotemeyer, K.-H., Suhr, B., & Husstedt, I.-W. (1999). Dynamic changes of cognitive habituation and serotonin metabolism during the migraine interval. Cephalalgia, 19, 485–491.
Ferrari, M. D. (1992). Biochemistry of migraine. Pathology Biology, 40, 284–292.
Gerber, W.-D., & Schoenen, J. (1998). Biobehavioral correlates in migraine: The role of hypersensitivity and information-processing dysfunction. Cephalalgia, 18, 5–11.
Goadsby, P. J. (1997). Current concepts of the pathophysiology of migraine. Neurology Clinics, 15, 27–42.
Göbel, H., Krapat, S., Ensink, F. B., & Soyka, D. (1993). Comparison of contingent negative variation between migraine interval and migraine attack before and after treatment with sumatriptan. Headache, 33,570–572.
Hardebo, J. E. (1992). A cortical excitatory wave may cause both the aura and the headache of migraine. Cephalalgia, 12, 75–80.
Kropp, P., & Gerber, W.-D. (1993). Is increased amplitude of contingent negative variation in migraine due to cortical hyperactivity or to reduced habituation? Cephalalgia, 13, 37–41.
Kropp, P., & Gerber, W.-D. (1995). Contingent negative variation during migraine attack and interval: Evidence for normalization of slow cortical potentials during the attack. Cephalalgia, 15, 123–128.
Kropp, P., & Gerber, W.-D. (1998). Prediction of migraine attacks using a slow cortical potential, the contingent negative variation. Neuroscience Letters, 257, 73–76.
Kropp, P., Siniatchkin, M., Stephani, U., & Gerber, W.-D. (1999). Migraine–evidence for a disturbance of cerebral maturation in man? Neuroscience Letters, 276, 181–184.
Lauritzen, M. (2001). Cortical spreading depression in migraine. Cephalalgia, 21(7), 757–760.
Lodi, R., Montagna, P., Soriani, S., Iotti, S., Araldi, C., Cortelli, P., et al. (1997). Deficit of brain and sceletal muscle bioenergetics and low brain magnesium in juvenile migraine: An in vivo 31P magnetic resonance spectroscopy study. Pediatric Research, 42, 866–871.
Lutzenberger, W., Roberts, L. E., & Birbaumer, W. (1993). Memory performance and area-specific self-regulation of slow cortical potentials: Dual-task interference. International Journal of Psychophysiology, 15, 217–226.
Maertens de Noordhout, A., Timsit-Berthier, M., Timsit, M., & Schoenen, J. (1986). Contingent negative variation in headache. Annals of Neurology, 19, 78–80.
Moskowitz, M. A. (1993). Neurogenic inflammation in the pathophysiology and treatment of migraine. Neurology, 41, 182–186.
Nagel-Leiby, S., Welch, K. M., D'Andrea, G., Grundfeld, S., & Brown, E. (1990). Event-related slow potentials and associated catecholamine function in migraine. Cephalalgia, 10, 317–329.
Oades, B. A., Dittmann-Balcar, A., & Zerbin, D. (1997). Development and topography of auditory event-related potentials (ERPs): Mismatch and processing negativity in individuals 8-22 years of age. Psychophysiology, 34, 677–693.
Rockstroh, B., Elbert, T., Birbaumer, N., Wolf, P., Düchting-Röth, A., Reker, M., et al. (1993). Cortical selfregulation in patients with epilepsies. Epilepsy Research, 14, 63–72.
Rockstroh, B., Elbert, T., Canavan, A., Lutzenberger, W., & Birbaumer, N. (1998). Slow cortical potentials and behavior (2nd ed.). Baltimore: Urban & Schwarzenberg.
Rohrbaugh, J.W., McCallum, W. C., Gaillard, A.W., Simons, R. F., Birbaumer, N., & Papakostopoulos, D. (1986). ERPs associated with preparatory and movement-related processes. A review. Electroencephalography and Clinical Neurophysiology, 38, 189–229.
Schoenen, J. (1986). Beta blockers and the central nervous system. Cephalalgia, 6, 47–54.
Schoenen, J. (1996). Abnormal cortical information processing between migraine attacks. In M. Sandler, M. Ferrari, & S. Harnett (Eds.), Migraine: Pharmacology and genetics (pp. 233–253). London: Altman.
Schoenen, J. (1998). The pathophysiology of migraine: A review based on the literature and on personal contributions. Functional Neurology, 1, 7–16.
Siniatchkin, M., Hierundar, A., Kropp, P., Kuhnert, R., & Gerber, W.-D. (2000). Self-regulation of slow cortical potentials in children with migraine: An exploratory study. Applied Psychophysiology and Biofeedback, 25(1), 13–32.
Wang, W., & Schoenen, J. (1998). Interictal potentiation of passive “oddball” auditory event-related potentials in migraine. Cephalalgia, 18, 261–265.
Weiller, C., May, A., Limmroth, V., Jupner, M., Kaube, H., Schayck, R. V., et al. (1995). Brain stem activation in spontaneous human migraine attacks. Nature Medicine, 1, 658–660.
Welch, K. M. A. (1989). The search for a universal hypothesis of migraine mechanisms. The Cummings Lecture. In F. Clifford-Rose (Ed.), New advances in headache research. Nishimura: Smith-Gordon.
Welch, K. M. A., Cao, Y., Aurora, S., Wigins, G., & Vikinstad, E. M. (1998). MRI of the occipital cortex, red nucleus, and substantia nigra during visual aura of migraine. Neurology, 51, 1465–1469.
Welch, K. M. A., & Ramadan, N. M. (1995). Mitochondria, magnesium and migraine. Journal of Neurological Sciences, 134, 9–14.
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Kropp, P., Siniatchkin, M. & Gerber, WD. On the Pathophysiology of Migraine—Links for “Empirically Based Treatment” with Neurofeedback. Appl Psychophysiol Biofeedback 27, 203–213 (2002). https://doi.org/10.1023/A:1016251912324
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DOI: https://doi.org/10.1023/A:1016251912324