Abstract
This cross-sectional analysis of a population-based cohort investigates the postural changes in blood pressure (BP) and heart rate and assesses the prevalence of orthostatic hypotension (OH) and its associations with the medicines used by an elderly population. The study population (n=1000) was a random sample of persons aged 75 years or older in the City of Kuopio, Finland. In 2004, altogether, 781 persons participated in the study. After the exclusion of persons living in institutional care (n=82) and those without orthostatic test (n=46), the final study population comprised 653 home-dwelling elderly persons. OH was defined as a ⩾20 mm Hg drop of systolic BP or a ⩾10 mm Hg drop of diastolic BP or both 1 or 3 min after standing up from supine position. Systolic BP dropped for more than half of the home-dwelling elderly when they stood up from a supine to a standing position. The total prevalence of OH was 34% (n=220). No significant gender or age differences were seen. The prevalence of OH was related to the total number of medicines in regular use (P<0.05). OH and postural changes in BP are more common among the home-dwelling elderly than reported in previous studies. The prevalence of OH is related to the number of medicines in regular use. There is an obvious need to measure orthostatic BP of elderly persons, as low BP and OH are important risk factors especially among the frail elderly persons.
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References
Rutan GH, Hermanson B, Bild DE, Kittner SJ, LaBaw F, Tell GS . Orthostatic hypotension in older adults. The Cardiovascular Health Study. For the CHS collaborative research group. Hypertension 1992; 19: 508–519.
Masaki KH, Schatz IJ, Burchfiel CM, Sharp DS, Chiu D, Foley D et al. Orthostatic hypotension predicts mortality in elderly men: The Honolulu Heart Program. Circulation 1998; 98: 2290–2295.
Luukinen H, Koski K, Laippala P, Kivela SL . Prognosis of diastolic and systolic orthostatic hypotension in older persons. Arch Intern Med 1999; 159: 273–280.
Räihä I, Luutonen S, Piha J, Seppänen A, Toikka T, Sourander L . Prevalence, predisposing factors, and prognostic importance of postural hypotension. Arch Intern Med 1995; 155: 930–935.
Atli T, Keven K . Orthostatic hypotension in the healthy elderly. Arch Gerontol Geriatr 2006; 43: 313–317.
Ooi WL, Barrett S, Hossain M, Kelley-Gagnon M, Lipsitz LA . Patterns of orthostatic blood pressure change and their clinical correlates in a frail, elderly population. JAMA 1997; 277: 1299–1304.
Ooi WL, Hossain M, Lipsitz LA . The association between orthostatic hypotension and recurrent falls in nursing home residents. Am J Med 2000; 108: 106–111.
Weiss A, Grossman E, Beloosesky Y, Grinblat J . Orthostatic hypotension in acute geriatric ward: Is it a consistent finding? Arch Intern Med 2002; 162: 2369–2374.
Poon IO, Braun U . High prevalence of orthostatic hypotension and its correlation with potentially causative medications among elderly veterans. J Clin Pharmcol Ther 2005; 30: 173–178.
Vloet LC, Pel-Little RE, Jansen PA, Jansen RW . High prevalence of postprandial and orthostatic hypotension among geriatric patients admitted to Dutch hospitals. J Gerontol A Biol Sci Med Sci 2005; 60: 1271–1277.
Weiss A, Beloosesky Y, Kornowski R, Yalov A, Grinblat J, Grossman E . Influence of orthostatic hypotension on mortality among patients discharged from an acute geriatric ward. J Gen Intern Med 2006; 21: 602–606.
Heitterachi E, Lord SR, Meyerkort P, McCloskey I, Fitzpatrick R . Blood pressure changes on upright tilting predict falls in older people. Age Ageing 2002; 31: 181–186.
Kario K, Tobin JN, Wolfson LI, Whipple R, Derby CA, Singh D et al. Lower standing systolic blood pressure as a predictor of falls in the elderly: a community-based prospective study. J Am Coll Cardiol 2001; 38: 246–252.
Mets TF . Drug-induced orthostatic hypotension in older patients. Drugs Aging 1995; 6: 219–228.
Gupta M, Lipsitz LA . Orthostatic hypotension in the elderly: diagnosis and treatment. Am J Med 2007; 120: 841–847.
Luukinen H, Koski K, Laippala P, Airaksinen KE . Orthostatic hypotension and the risk of myocardial infarction in the home-dwelling elderly. J Intern Med 2004; 255: 486–493.
Liu BA, Topper AK, Reeves RA, Gryfe C, Maki BE . Falls among older people: Relationship to medication use and orthostatic hypotension. J Am Geriatr Soc 1995; 43: 1141–1145.
Souverein PC, Van Staa TP, Egberts AC, De la Rosette JJ, Cooper C, Leufkens HG . Use of alpha-blockers and the risk of hip/femur fractures. J Intern Med 2003; 254: 548–554.
Bradley JG, Davis KA . Orthostatic Hypotension. Am Fam Physician 2003; 68: 2393–2398.
WHO. Guidelines for ATC Classification and DDD Assignment. WHO Collaborating Centre for Drug Statistics Methodology: Oslo, 2003.
National Agency for Medicines. Classification of Medicines (ATC) and Defined Daily Doses (DDD) 2004. National Agency for Medicines: Helsinki, 2004.
The Consensus Committee of the American Autonomic Society and the American Academy of Neurology. Consensus statement on the definition of orthostatic hypotension, pure autonomic failure, and multiple system atrophy. Neurology 1996; 46: 1470.
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders: DSM-IV. 4th edn. American Psychiatric Association: Washington, DC, 1994.
Boddaert J, Tamim H, Verny M, Belmin J . Arterial stiffness is associated with orthostatic hypotension in elderly subjects with history of falls. J Am Geriatr Soc 2004; 52: 568–572.
Blacher J, Staessen JA, Girerd X, Gasowski J, Thijs L, Wang JG et al. Pulse pressure not mean pressure determines cardiovascular risk in older hypertensive patients. Arch Intern Med 2000; 160: 1085–1089.
Vloet LC, Smits R, Frederiks CM, Hoefnagels WH, Jansen RW . Evaluation of skills and knowledge on orthostatic blood pressure measurements in elderly patients. Age Ageing 2002; 31: 211–216.
Acknowledgements
We thank statistician Piia Lavikainen for her help with the statistics and research secretary Päivi Heikura for updating and managing the database. This study was supported by Social Insurance Institution of Finland and City of Kuopio.
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Hiitola, P., Enlund, H., Kettunen, R. et al. Postural changes in blood pressure and the prevalence of orthostatic hypotension among home-dwelling elderly aged 75 years or older. J Hum Hypertens 23, 33–39 (2009). https://doi.org/10.1038/jhh.2008.81
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DOI: https://doi.org/10.1038/jhh.2008.81
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