Case ReportGoodpasture syndrome during the course of a Schönlein-Henoch purpura☆,☆☆
Section snippets
Case report
A 69-year-old patient had undergone surgery 2 months before admission to our department. The patient had been a smoker up to 2 months before admission, was hypertensive on medical treatment, and had a past medical history of bronchogenic squamous cell carcinoma in the right upper lobe (4.5 cm in diameter, infiltrating parietal pleura, without hilar or mediastinal lymph node involvement). A superior and medial bilobectomy had been performed with mediastinal lymphadenectomy and section of the
Discussion
The diagnosis of Goodpasture syndrome requires the demonstration of anti-GBM circulating antibodies and a characteristic linear pattern on direct immunofluorescence, which is usually IgG, but occasionally non-IgG antibodies can be present or both.4 Lung neoplasms have been noted among the precipitating factors that can trigger Schönlein-Henoch purpura.5 In the present case, although we did not have pathology samples of the pulmonary lesions, the presence of glomerulonephritis with linear IgA
References (14)
- et al.
Asymptomatic IgA nephropathy associated with pulmonary hemosiderosis
Am J Med
(1978) - et al.
Recurrent Goodpasture's disease due to a monoclonal IgA-kappa circulating antibody
Am J Kidney Dis
(1999) - et al.
Pulmonary hemorrhage in Henoch Schönlein purpura
Thorax
(1989) - et al.
Henoch-Schönlein purpura and pulmonary hemorrhage: A report and literature review
Pediatr Nephrol
(1999) - et al.
Henoch Schönlein nephritis
Clin Nephrol
(1999) - et al.
IgA-mediated renal diseases: Is there an IgA variant of Goodpasture syndrome?
Am J Kidney Dis
(1999) - et al.
Henoch-Schönlein purpura nephritis
J Am Soc Nephrol
(1999)
Cited by (16)
Binding Truths: Atypical Anti−Glomerular Basement Membrane Disease Mediated by IgA Anti−Glomerular Basement Membrane Antibodies Targeting the α1 Chain of Type IV Collagen
2019, Kidney International ReportsCitation Excerpt :Among 53 patients who presented with anti-GBM disease in 2 local renal units over the past 3 decades, this has been the only case of IgA-mediated disease that we have encountered. So far, only 13 cases have been reported in the literature.3–16 In all cases, the histology was consistent with crescentic glomerulonephritis and demonstrated linear GBM staining with IgA.
The pulmonary-renal syndrome: A diagnostic and therapeutic emergency for the internist and the intensivist
2013, Revue de Medecine InterneGoodpasture syndrome and anti-glomerular basement membrane disease
2023, Clinical and Experimental RheumatologyAtypical anti-glomerular basement membrane disease with IgA nephropathy: A case report
2017, International Journal of Clinical and Experimental Medicine
- ☆
Address reprint requests to Luis Carreras, MD, PhD, Scio de Nefrología, Hospital Princeps d'Espanya, CSUB, Feixa Llarga s/n, 08907 L'Hospitalet de Llobregat, Barcelona, Spain. E-mail: [email protected]
- ☆☆
1523-6838/02/3905-0027$35.00/0