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Z Gastroenterol 2014; 52(12): 1431-1484
DOI: 10.1055/s-0034-1385199
Leitlinie
© Georg Thieme Verlag KG Stuttgart · New York

Aktualisierte S3-Leitlinie – „Diagnostik und Therapie des Morbus Crohn“ 2014[1]

AWMF-Registriernummer: 021–004Updated German Clinical Practice Guideline on “Diagnosis and treatment of Crohn's disease” 2014AWMF registration no.: 021–004
J. C. Preiß
1   Medizinische Klinik für Gastroenterologie, Infektiologie und Rheumatologie, Charité – Universitätsmedizin Berlin, Campus Benjamin Franklin
,
B. Bokemeyer
2   Gastroenterologische Gemeinschaftspraxis Minden
,
H. J. Buhr
3   Deutsche Gesellschaft für Allgemein- und Viszeralchirurgie, Berlin
,
A. Dignaß
4   Medizinische Klinik I, Agaplesion Markus-Krankenhaus, Frankfurt/Main
,
W. Häuser
5   Klinik Innere Medizin I, Klinikum Saarbrücken
,
F. Hartmann
6   Agaplesion MVZ, Frankfurt/Main
,
K. R. Herrlinger
7   Innere Medizin I, Asklepios Klinik Nord, Hamburg
,
B. Kaltz
8   Deutsche Morbus Crohn/Colitis ulcerosa Vereinigung (DCCV) e. V., Berlin
,
P. Kienle
9   Chirurgische Klinik, Universitätsmedizin Mannheim
,
W. Kruis
10   Abteilung für Innere Medizin, Evangelisches Krankenhaus Kalk, Köln
,
T. Kucharzik
11   Klinik für Allgemeine Innere Medizin & Gastroenterologie, Klinikum Lüneburg
,
J. Langhorst
12   Integrative Gastroenterologie, Klinik für Naturheilkunde und Integrative Medizin, Kliniken Essen-Mitte
,
S. Schreiber
13   Medizinische Klinik I, Universitätsklinikum Schleswig-Holstein, Campus Kiel
,
B. Siegmund
1   Medizinische Klinik für Gastroenterologie, Infektiologie und Rheumatologie, Charité – Universitätsmedizin Berlin, Campus Benjamin Franklin
,
A. Stallmach
14   Klinik für Innere Medizin IV, Universitätsklinikum Jena
,
E. F. Stange
15   Abteilung für Gastroenterologie, Hepatologie und Endokrinologie, Robert-Bosch-Krankenhaus, Stuttgart
,
J. Stein
16   Abteilung Gastroenterologie/Ernährungsmedizin, DGD Kliniken Frankfurt Sachsenhausen, Frankfurt/Main
,
J. C. Hoffmann
17   Medizinische Klinik I, St. Marien- und St. Annastiftskrankenhaus, Ludwigshafen
› Author Affiliations
Further Information

Publication History

Publication Date:
04 December 2014 (online)

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Einführung

Der Morbus Crohn (ICD-10: K50) ist neben der Colitis ulcerosa (ICD-10: K51) die wichtigste chronisch-entzündliche Darmerkrankung. Für den M. Crohn wurde in Deutschland zuletzt eine Inzidenz bis 6,6 pro 100 000 Einwohner berichtet [1]. Die Prävalenz dürfte bei 100 – 200 pro 100 000 Einwohner liegen [2] [3]. Die höchste altersspezfische Inzidenz liegt im dritten Lebensjahrzehnt, das mediane Erkrankungsalter bei 33 Jahren [4]. Somit beginnt für die meisten Patienten mit M. Crohn ihre Erkrankung während der Berufsausbildung und dauert während ihres gesamten beruflichen Lebens an. Daraus folgt, dass durch die Erkrankung nicht nur direkte Kosten (Medikamente, Arztbesuche, Operationen, Krankenhausaufenthalte etc.), sondern auch umfangreiche indirekte Kosten (Rente, Arbeitsausfälle etc.) entstehen. Es ist davon auszugehen, dass bei Patienten mit M. Crohn fast zwei Drittel (64 %) der Gesamtkosten den indirekten Kosten zuzuordnen sind [5]. An direkten medizinischen Kosten wurden dabei zuletzt zwischen 3500 und 6000 € pro Jahr für einen Patienten mit M. Crohn errechnet. Insgesamt entfielen 69 % der direkten Kosten allein auf Arzneimittelkosten [5] [6]. Hochgerechnet werden allein in Deutschland 2 – 3 Milliarden Euro pro Jahr für die Versorgung von Patienten mit M. Crohn aufgewandt.

Eine besondere Untergruppe von Patienten mit M. Crohn sind Kinder und Jugendliche. 19 % aller an M. Crohn Erkrankten sind unter 20 Jahre alt, vereinzelt beginnt die Erkrankung im Säuglingsalter [4]. Das Symptommuster unterscheidet sich bei Kindern von dem erwachsener Patienten. Die Behandlung von Kindern und Jugendlichen vor und während der Pubertät bis zum Abschluss des Wachstums sollte durch den in der Gastroenterologie spezialisierten Facharzt für Kinder- und Jugendmedizin erfolgen. Der klinische Verlauf, das Befallsmuster und das Ausmaß an extraintestinalen Manifestationen sind zudem sehr variabel. Daraus ergibt sich die Notwendigkeit einer komplexen Diagnostik und einer abgestuften Therapie in der klinischen Praxis.

Die jetzt überarbeitete Leitlinie basiert wesentlich auf der Leitlinie der DGVS aus dem Jahr 2008 sowie der Leitlinie der European Crohn’s and Colitis Organization (ECCO) von 2010 und der Colitis-ulcerosa-Leitlinie der DGVS von 2011 [7] [8] [9] [10] [11].

Einige Teilgebiete aus der Diagnostik und Therapie der chronisch-entzündlichen Darmerkrankungen (CED) wurden 2011 ausführlich in der Colitis-ulcerosa-Leitlinie dargestellt und wurden daher hier nicht mehr aufgearbeitet. Daher wird in den Abschnitten zur Karzinomüberwachung, der Psychosomatik und der Komplementär- und Alternativmedizin teilweise auf die Empfehlungen der Colitis-ulcerosa-Leitlinie verwiesen. Die Empfehlungen zu Schwangerschaft und Stillen, zur Schmerztherapie und zu extraintestinalen Manifestationen und Komplikationen wurden hingegen in dieser Leitlinie ausführlich überarbeitet und sollen daher in der nächsten Colitis-ulcerosa-Leitlinie übernommen werden.

Die methodischen Grundlagen für den organisatorischen Ablauf des Konsensusprozesses war das AWMF-Regelwerk Leitlinien, das Deutsche Leitlinien-Bewertungsinstrument (DELBI) und die Levels of Evidence and Grades of Recommendation vom März 2009 des Oxford-Centre for Evidence Based Medicine [12] [13] [14]. Durch den im Folgenden beschriebenen organisatorischen Ablauf und die dargestellte Methodik zur Ableitung von Empfehlungen erfüllt die Leitlinie die Kriterien einer evidenzbasierten Konsensusleitlinie (Stufe 3).

1 Erstellt unter Federführung der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS) unter Beteiligung von Deutsche Gesellschaft für Allgemein- und Viszeralchirurgie (DGAV), Deutsche Gesellschaft für Chirurgie (DGCh), Deutsche Gesellschaft für Innere Medizin (DGIM), Deutsche Gesellschaft für Koloproktologie (DGK), Deutsche Morbus Crohn/Colitis ulcerosa Vereinigung (DCCV), Gesellschaft für Pädiatrische Gastroenterologie und Ernährung (GPGE), Kompetenznetz chronisch entzündliche Darmerkrankungen.


 

  • Literatur

  • 1 Ott C, Obermeier F, Thieler S et al. The incidence of inflammatory bowel disease in a rural region of Southern Germany: a prospective population-based study. Eur J Gastroenterol Hepatol 2008; 20: 917-923
    CrossrefPubMedGoogle Scholar
  • 2 Timmer A. Epidemiologie der CED. In: Hoffmann JC, Kroesen AJ, Klump B, Hrsg Chronisch entzündliche Darmerkrankungen – Handbuch für die Praxis. 2. Aufl. Stuttgart, New York: Georg Thieme Verlag; 2009: 8-24
    Google Scholar
  • 3 Molodecky NA, Soon IS, Rabi DM et al. Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review. Gastroenterology 2012; 142: 46-54 e42 ; quiz e30
    CrossrefPubMedGoogle Scholar
  • 4 Loftus CG, Loftus Jr EV, Harmsen WS et al. Update on the incidence and prevalence of Crohn's disease and ulcerative colitis in Olmsted County, Minnesota, 1940–2000. Inflamm Bowel Dis 2007; 13: 254-261
    CrossrefPubMedGoogle Scholar
  • 5 Stark R, Konig HH, Leidl R. Costs of inflammatory bowel disease in Germany. PharmacoEconomics 2006; 24: 797-814
    CrossrefPubMedGoogle Scholar
  • 6 Prenzler A, Mittendorf T, Conrad S et al. Die direkten Kosten der Versorgung von Patienten mit Morbus Crohn aus der Perspektive der Gesetzlichen Krankenversicherung. Z Gastroenterol 2009; 47: 659-666
    Article in Thieme ConnectPubMedGoogle Scholar
  • 7 Hoffmann JC, Preiß JC, Autschbach F et al. S3-Leitlinie „Diagnostik und Therapie des Morbus Crohn“. Z Gastroenterol 2008; 46: 1094-1146
    Article in Thieme ConnectPubMedGoogle Scholar
  • 8 Van Assche G, Dignass A, Panes J et al. The second European evidence-based Consensus on the diagnosis and management of Crohn's disease: Definitions and diagnosis. Journal of Crohn's & colitis 2010; 4: 7-27
    PubMedGoogle Scholar
  • 9 Dignaß A, Van Assche G, Lindsay JO et al. The second European evidence-based Consensus on the diagnosis and management of Crohn's disease: Current management. Journal of Crohn's & colitis 2010; 4: 28-62
    PubMedGoogle Scholar
  • 10 Van Assche G, Dignass A, Reinisch W et al. The second European evidence-based Consensus on the diagnosis and management of Crohn's disease: Special situations. Journal of Crohn's & colitis 2010; 4: 63-101
    PubMedGoogle Scholar
  • 11 Dignaß A, Preiß JC, Aust DE et al. Aktualisierte Leitlinie zur Diagnostik und Therapie der Colitis ulcerosa 2011 – Ergebnisse einer evidenzbasierten Konsensuskonferenz. Z Gastroenterol 2011; 49: 1276-1341
    Article in Thieme ConnectPubMedGoogle Scholar
  • 12 Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF) – Ständige Kommission Leitlinien. AWMF-Regelwerk „Leitlinien“. 2012 1. Aufl. Im Internet: http://www.awmf.org/leitlinien/awmf-regelwerk.html Zugriff: 23.11.2013
    PubMedGoogle Scholar
  • 13 Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften, Ärztliche Zentralstelle Qualitätssicherung. Deutsches Instrument zur methodischen Leitlinien-Bewertung (DELBI) – Fassung 2005/2006 + Domäne 8 (2008). 2008 Im Internet: www.delbi.de Zugriff: 23.11.2013
    PubMedGoogle Scholar
  • 14 Phillips B, Ball C, Sackett D et al. Oxford Centre for Evidence-based Medicine – Levels of Evidence (March 2009). 2013 Im Internet: http://www.cebm.net/index.aspx?o=1025 Zugriff: 30.04.2014
    PubMedGoogle Scholar
  • 15 Preiß JC, Hoffmann JC, Lynen Jansen P. Leitlinienreport zur Aktualisierten Leitlinie "Diagnostik und Therapie des M. Crohn". 2014 Im Internet: www.awmf.org/leitlinien/detail/ll/021-004.html Zugriff: 30.04.2014
    PubMedGoogle Scholar
  • 16 Lynen Jansen P, Preiß JC, Muche-Borowski C et al. Das Leitlinienprogramm der DGVS. Z Gastroenterol 2013; 51: 643-650
    Article in Thieme ConnectPubMedGoogle Scholar
  • 17 Lennard-Jones JE, Shivananda S. Clinical uniformity of inflammatory bowel disease a presentation and during the first year of disease in the north and south of Europe. EC-IBD Study Group. Eur J Gastroenterol Hepatol 1997; 9: 353-359
    CrossrefPubMedGoogle Scholar
  • 18 Bridger S, Lee JC, Bjarnason I et al. In siblings with similar genetic susceptibility for inflammatory bowel disease, smokers tend to develop Crohn's disease and non-smokers develop ulcerative colitis. Gut 2002; 51: 21-25
    CrossrefPubMedGoogle Scholar
  • 19 Ogura Y, Bonen DK, Inohara N et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 2001; 411: 603-606
    CrossrefPubMedGoogle Scholar
  • 20 Hugot JP, Chamaillard M, Zouali H et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 2001; 411: 599-603
    CrossrefPubMedGoogle Scholar
  • 21 Ahmad T, Armuzzi A, Bunce M et al. The molecular classification of the clinical manifestations of Crohn's disease. Gastroenterology 2002; 122: 854-866
    CrossrefPubMedGoogle Scholar
  • 22 Lesage S, Zouali H, Cezard JP et al. CARD15 / NOD2 mutational analysis and genotype-phenotype correlation in 612 patients with inflammatory bowel disease. Am J Hum Genet 2002; 70: 845-857
    CrossrefPubMedGoogle Scholar
  • 23 Radlmayr M, Torok HP, Martin K et al. The c-insertion mutation of the NOD2 gene is associated with fistulizing and fibrostenotic phenotypes in Crohn's disease. Gastroenterology 2002; 122: 2091-2092
    PubMedGoogle Scholar
  • 24 Peeters M, Joossens S, Vermeire S et al. Diagnostic value of anti-Saccharomyces cerevisiae and antineutrophil cytoplasmic autoantibodies in inflammatory bowel disease. Am J Gastroenterol 2001; 96: 730-734
    CrossrefPubMedGoogle Scholar
  • 25 Zholudev A, Zurakowski D, Young W et al. Serologic testing with ANCA, ASCA, and anti-OmpC in children and young adults with Crohn's disease and ulcerative colitis: diagnostic value and correlation with disease phenotype. Am J Gastroenterol 2004; 99: 2235-2241
    CrossrefPubMedGoogle Scholar
  • 26 Plevy S. Do serological markers and cytokines determine the indeterminate?. J Clin Gastroenterol 2004; 38: S51-S56
    CrossrefPubMedGoogle Scholar
  • 27 Schumacher G, Sandstedt B, Kollberg B. A prospective study of first attacks of inflammatory bowel disease and infectious colitis. Clinical findings and early diagnosis. Scand J Gastroenterol 1994; 29: 265-274
    PubMedGoogle Scholar
  • 28 Andersson RE, Olaison G, Tysk C et al. Appendectomy is followed by increased risk of Crohn's disease. Gastroenterology 2003; 124: 40-46
    CrossrefPubMedGoogle Scholar
  • 29 Garcia RodriguezLA, Ruigomez A, Panes J. Acute gastroenteritis is followed by an increased risk of inflammatory bowel disease. Gastroenterology 2006; 130: 1588-1594
    CrossrefPubMedGoogle Scholar
  • 30 IBD Working Group of the European Society for Paediatric Gastroenterology Hepatology and Nutrition. Inflammatory bowel disease in children and adolescents: recommendations for diagnosis – the Porto criteria. J Pediatr Gastroenterol Nutr 2005; 41: 1-7
    CrossrefPubMedGoogle Scholar
  • 31 Fagan EA, Dyck RF, Maton PN et al. Serum levels of C-reactive protein in Crohn's disease and ulcerative colitis. Eur J Clin Invest 1982; 12: 351-359
    CrossrefPubMedGoogle Scholar
  • 32 Vermeire S, Van Assche G, Rutgeerts P. C-reactive protein as a marker for inflammatory bowel disease. Inflamm Bowel Dis 2004; 10: 661-665
    CrossrefPubMedGoogle Scholar
  • 33 Solem CA, Loftus Jr EV, Tremaine WJ et al. Correlation of C-reactive protein with clinical, endoscopic, histologic, and radiographic activity in inflammatory bowel disease. Inflamm Bowel Dis 2005; 11: 707-712
    CrossrefPubMedGoogle Scholar
  • 34 Mylonaki M, Langmead L, Pantes A et al. Enteric infection in relapse of inflammatory bowel disease: importance of microbiological examination of stool. Eur J Gastroenterol Hepatol 2004; 16: 775-778
    CrossrefPubMedGoogle Scholar
  • 35 Boirivant M, Leoni M, Tariciotti D et al. The clinical significance of serum C reactive protein levels in Crohn's disease. Results of a prospective longitudinal study. J Clin Gastroenterol 1988; 10: 401-405
    CrossrefPubMedGoogle Scholar
  • 36 Schoepfer AM, Beglinger C, Straumann A et al. Fecal calprotectin correlates more closely with the Simple Endoscopic Score for Crohn's disease (SES-CD) than CRP, blood leukocytes, and the CDAI. Am J Gastroenterol 2010; 105: 162-169
    CrossrefPubMedGoogle Scholar
  • 37 Langhorst J, Elsenbruch S, Koelzer J et al. Noninvasive markers in the assessment of intestinal inflammation in inflammatory bowel diseases: performance of fecal lactoferrin, calprotectin, and PMN-elastase, CRP, and clinical indices. American Journal of Gastroenterology 2008; 103: 162-169
    CrossrefPubMedGoogle Scholar
  • 38 Geerling BJ, Badart-Smook A, Stockbrugger RW et al. Comprehensive nutritional status in recently diagnosed patients with inflammatory bowel disease compared with population controls. Eur J Clin Nutr 2000; 54: 514-521
    CrossrefPubMedGoogle Scholar
  • 39 Filippi J, Al-Jaouni R, Wiroth JB et al. Nutritional deficiencies in patients with Crohn's disease in remission. Inflamm Bowel Dis 2006; 12: 185-191
    CrossrefPubMedGoogle Scholar
  • 40 Aadland E, Fagerhol MK. Faecal calprotectin: a marker of inflammation throughout the intestinal tract. Eur J Gastroenterol Hepatol 2002; 14: 823-825
    CrossrefPubMedGoogle Scholar
  • 41 Sipponen T, Savilahti E, Kolho KL et al. Crohn's disease activity assessed by fecal calprotectin and lactoferrin: correlation with Crohn's disease activity index and endoscopic findings. Inflamm Bowel Dis 2008; 14: 40-46
    CrossrefPubMedGoogle Scholar
  • 42 von Roon AC, Karamountzos L, Purkayastha S et al. Diagnostic precision of fecal calprotectin for inflammatory bowel disease and colorectal malignancy. Am J Gastroenterol 2007; 102: 803-813
    Google Scholar
  • 43 van Rheenen PF, Van de Vijver E, Fidler V. Faecal calprotectin for screening of patients with suspected inflammatory bowel disease: diagnostic meta-analysis. BMJ 2010; 341: c3369
    CrossrefPubMedGoogle Scholar
  • 44 Jensen MD, Kjeldsen J, Nathan T. Fecal calprotectin is equally sensitive in Crohn's disease affecting the small bowel and colon. Scand J Gastroenterol 2011; 46: 694-700
    CrossrefPubMedGoogle Scholar
  • 45 Korczowski B, Szybist W. Serum procalcitonin and C-reactive protein in children with diarrhoea of various aetiologies. Acta Paediatr 2004; 93: 169-173
    CrossrefPubMedGoogle Scholar
  • 46 Herrlinger KR, Dittmann R, Weitz G et al. Serum procalcitonin differentiates inflammatory bowel disease and self-limited colitis. Inflamm Bowel Dis 2004; 10: 229-233
    CrossrefPubMedGoogle Scholar
  • 47 Rodemann JF, Dubberke ER, Reske KA et al. Incidence of Clostridium difficile infection in inflammatory bowel disease. Clin Gastroenterol Hepatol 2007; 5: 339-344
    CrossrefPubMedGoogle Scholar
  • 48 Issa M, Vijayapal A, Graham MB et al. Impact of Clostridium difficile on inflammatory bowel disease. Clin Gastroenterol Hepatol 2007; 5: 345-351
    CrossrefPubMedGoogle Scholar
  • 49 Ananthakrishnan AN, McGinley EL, Binion DG. Excess hospitalisation burden associated with Clostridium difficile in patients with inflammatory bowel disease. Gut 2008; 57: 205-210
    CrossrefPubMedGoogle Scholar
  • 50 Takahashi Y, Tange T. Prevalence of cytomegalovirus infection in inflammatory bowel disease patients. Dis Colon Rectum 2004; 47: 722-726
    CrossrefPubMedGoogle Scholar
  • 51 Dimitroulia E, Spanakis N, Konstantinidou AE et al. Frequent detection of cytomegalovirus in the intestine of patients with inflammatory bowel disease. Inflamm Bowel Dis 2006; 12: 879-884
    CrossrefPubMedGoogle Scholar
  • 52 Cottone M, Pietrosi G, Martorana G et al. Prevalence of cytomegalovirus infection in severe refractory ulcerative and Crohn's colitis. Am J Gastroenterol 2001; 96: 773-775
    CrossrefPubMedGoogle Scholar
  • 53 Hommes DW, Sterringa G, van Deventer SJ et al. The pathogenicity of cytomegalovirus in inflammatory bowel disease: a systematic review and evidence-based recommendations for future research. Inflamm Bowel Dis 2004; 10: 245-250
    CrossrefPubMedGoogle Scholar
  • 54 Pascu M, Roznowski AB, Muller HP et al. Clinical relevance of transabdominal ultrasonography and magnetic resonance imaging in patients with inflammatory bowel disease of the terminal ileum and large bowel. Inflamm Bowel Dis 2004; 10: 373-382
    CrossrefPubMedGoogle Scholar
  • 55 Parente F, Greco S, Molteni M et al. Role of early ultrasound in detecting inflammatory intestinal disorders and identifying their anatomical location within the bowel. Aliment Pharmacol Ther 2003; 18: 1009-1016
    CrossrefPubMedGoogle Scholar
  • 56 Parente F, Greco S, Molteni M et al. Oral contrast enhanced bowel ultrasonography in the assessment of small intestine Crohn's disease. A prospective comparison with conventional ultrasound, x ray studies, and ileocolonoscopy. Gut 2004; 53: 1652-1657
    CrossrefPubMedGoogle Scholar
  • 57 Migaleddu V, Scanu AM, Quaia E et al. Contrast-enhanced ultrasonographic evaluation of inflammatory activity in Crohn's disease. Gastroenterology 2009; 137: 43-52
    CrossrefPubMedGoogle Scholar
  • 58 Pallotta N, Vincoli G, Montesani C et al. Small intestine contrast ultrasonography (SICUS) for the detection of small bowel complications in crohn's disease: a prospective comparative study versus intraoperative findings. Inflamm Bowel Dis 2012; 18: 74-84
    CrossrefPubMedGoogle Scholar
  • 59 Schmidt T, Hohl C, Haage P et al. Phase-inversion tissue harmonic imaging compared to fundamental B-mode ultrasound in the evaluation of the pathology of large and small bowel. Eur Radiol 2005; 15: 2021-2030
    CrossrefPubMedGoogle Scholar
  • 60 Maconi G, Sampietro GM, Parente F et al. Contrast radiology, computed tomography and ultrasonography in detecting internal fistulas and intra-abdominal abscesses in Crohn's disease: a prospective comparative study. Am J Gastroenterol 2003; 98: 1545-1555
    CrossrefPubMedGoogle Scholar
  • 61 Coremans G, Rutgeerts P, Geboes K et al. The value of ileoscopy with biopsy in the diagnosis of intestinal Crohn's disease. Gastrointest Endosc 1984; 30: 167-172
    CrossrefPubMedGoogle Scholar
  • 62 Wagtmans MJ, Verspaget HW, Lamers CB et al. Clinical aspects of Crohn's disease of the upper gastrointestinal tract: a comparison with distal Crohn's disease. Am J Gastroenterol 1997; 92: 1467-1471
    PubMedGoogle Scholar
  • 63 Rutgeerts P, Onette E, Vantrappen G et al. Crohn's disease of the stomach and duodenum: A clinical study with emphasis on the value of endoscopy and endoscopic biopsies. Endoscopy 1980; 12: 288-294
    Article in Thieme ConnectPubMedGoogle Scholar
  • 64 Mossop H, Davies P, Murphy MS. Predicting the need for azathioprine at first presentation in children with inflammatory bowel disease. J Pediatr Gastroenterol Nutr 2008; 47: 123-129
    CrossrefPubMedGoogle Scholar
  • 65 Rubio CA, Sjodahl K, Lagergren J. Lymphocytic esophagitis: a histologic subset of chronic esophagitis. American journal of clinical pathology 2006; 125: 432-437
    CrossrefPubMedGoogle Scholar
  • 66 Ebach DR, Vanderheyden AD, Ellison JM et al. Lymphocytic esophagitis: a possible manifestation of pediatric upper gastrointestinal Crohn's disease. Inflamm Bowel Dis 2011; 17: 45-49
    CrossrefPubMedGoogle Scholar
  • 67 Schreyer AG, Geissler A, Albrich H et al. Abdominal MRI after enteroclysis or with oral contrast in patients with suspected or proven Crohn's disease. Clin Gastroenterol Hepatol 2004; 2: 491-497
    CrossrefPubMedGoogle Scholar
  • 68 Schreyer AG, Seitz J, Feuerbach S et al. Modern imaging using computer tomography and magnetic resonance imaging for inflammatory bowel disease (IBD) AU1. Inflamm Bowel Dis 2004; 10: 45-54
    CrossrefPubMedGoogle Scholar
  • 69 Bernstein CN, Greenberg H, Boult I et al. A prospective comparison study of MRI versus small bowel follow-through in recurrent Crohn's disease. Am J Gastroenterol 2005; 100: 2493-2502
    CrossrefPubMedGoogle Scholar
  • 70 Albert JG, Martiny F, Krummenerl A et al. Diagnosis of small bowel Crohn's disease: a prospective comparison of capsule endoscopy with magnetic resonance imaging and fluoroscopic enteroclysis. Gut 2005; 54: 1721-1727
    CrossrefPubMedGoogle Scholar
  • 71 Jensen MD, Nathan T, Rafaelsen SR et al. Diagnostic accuracy of capsule endoscopy for small bowel Crohn's disease is superior to that of MR enterography or CT enterography. Clin Gastroenterol Hepatol 2011; 9: 124-129
    CrossrefPubMedGoogle Scholar
  • 72 de Ridder L, Mensink PB, Lequin MH et al. Single-balloon enteroscopy, magnetic resonance enterography, and abdominal US useful for evaluation of small-bowel disease in children with (suspected) Crohn's disease. Gastrointest Endosc 2012; 75: 87-94
    CrossrefPubMedGoogle Scholar
  • 73 Horsthuis K, Bipat S, Bennink RJ et al. Inflammatory bowel disease diagnosed with US, MR, scintigraphy, and CT: meta-analysis of prospective studies. Radiology 2008; 247: 64-79
    CrossrefPubMedGoogle Scholar
  • 74 Panes J, Bouzas R, Chaparro M et al. Systematic review: the use of ultrasonography, computed tomography and magnetic resonance imaging for the diagnosis, assessment of activity and abdominal complications of Crohn's disease. Aliment Pharmacol Ther 2011; 34: 125-145
    CrossrefPubMedGoogle Scholar
  • 75 Miao YM, Koh DM, Amin Z et al. Ultrasound and magnetic resonance imaging assessmentof active bowel segments in Crohn's disease. Clin Radiol 2002; 57: 913-918
    CrossrefPubMedGoogle Scholar
  • 76 Heyne R, Rickes S, Bock P et al. Non-invasive evaluation of activity in inflammatory bowel disease by power Doppler sonography. Z Gastroenterol 2002; 40: 171-175
    Article in Thieme ConnectPubMedGoogle Scholar
  • 77 Kohn A, Cerro P, Milite G et al. Prospective evaluation of transabdominal bowel sonography in the diagnosis of intestinal obstruction in Crohn's disease: comparison with plain abdominal film and small bowel enteroclysis. Inflamm Bowel Dis 1999; 5: 153-157
    CrossrefPubMedGoogle Scholar
  • 78 Gasche C, Moser G, Turetschek K et al. Transabdominal bowel sonography for the detection of intestinal complications in Crohn's disease. Gut 1999; 44: 112-117
    CrossrefPubMedGoogle Scholar
  • 79 Martinez MJ, Ripolles T, Paredes JM et al. Assessment of the extension and the inflammatory activity in Crohn's disease: comparison of ultrasound and MRI. Abdominal imaging 2009; 34: 141-148
    CrossrefPubMedGoogle Scholar
  • 80 Potthast S, Rieber A, Von Tirpitz C et al. Ultrasound and magnetic resonance imaging in Crohn's disease: a comparison. Eur Radiol 2002; 12: 1416-1422
    CrossrefPubMedGoogle Scholar
  • 81 Kroeker KI, Lam S, Birchall I et al. Patients with IBD are exposed to high levels of ionizing radiation through CT scan diagnostic imaging: a five-year study. J Clin Gastroenterol 2011; 45: 34-39
    CrossrefPubMedGoogle Scholar
  • 82 Desmond AN, O'Regan K, Curran C et al. Crohn's disease: factors associated with exposure to high levels of diagnostic radiation. Gut 2008; 57: 1524-1529
    CrossrefPubMedGoogle Scholar
  • 83 Chatu S, Subramanian V, Pollok RC. Meta-analysis: diagnostic medical radiation exposure in inflammatory bowel disease. Aliment Pharmacol Ther 2012; 35: 529-539
    CrossrefPubMedGoogle Scholar
  • 84 Hall EJ, Brenner DJ. Cancer risks from diagnostic radiology. The British journal of radiology 2008; 81: 362-378
    CrossrefPubMedGoogle Scholar
  • 85 Brenner DJ, Hall EJ. Computed tomography – an increasing source of radiation exposure. The New England journal of medicine 2007; 357: 2277-2284
    CrossrefPubMedGoogle Scholar
  • 86 Lee SS, Kim AY, Yang SK et al. Crohn disease of the small bowel: comparison of CT enterography, MR enterography, and small-bowel follow-through as diagnostic techniques. Radiology 2009; 251: 751-761
    CrossrefPubMedGoogle Scholar
  • 87 Maccioni F, Bruni A, Viscido A et al. MR imaging in patients with Crohn disease: value of T2- versus T1-weighted gadolinium-enhanced MR sequences with use of an oral superparamagnetic contrast agent. Radiology 2006; 238: 517-530
    CrossrefPubMedGoogle Scholar
  • 88 Golder SK, Schreyer AG, Endlicher E et al. Comparison of capsule endoscopy and magnetic resonance (MR) enteroclysis in suspected small bowel disease. Int J Colorectal Dis 2006; 21: 97-104
    CrossrefPubMedGoogle Scholar
  • 89 Voderholzer WA, Beinhoelzl J, Rogalla P et al. Small bowel involvement in Crohn's disease: a prospective comparison of wireless capsule endoscopy and computed tomography enteroclysis. Gut 2005; 54: 369-373
    CrossrefPubMedGoogle Scholar
  • 90 Liangpunsakul S, Chadalawada V, Rex DK et al. Wireless capsule endoscopy detects small bowel ulcers in patients with normal results from state of the art enteroclysis. Am J Gastroenterol 2003; 98: 1295-1298
    CrossrefPubMedGoogle Scholar
  • 91 Eliakim R, Fischer D, Suissa A et al. Wireless capsule video endoscopy is a superior diagnostic tool in comparison to barium follow-through and computerized tomography in patients with suspected Crohn's disease. Eur J Gastroenterol Hepatol 2003; 15: 363-367
    Google Scholar
  • 92 Triester SL, Leighton JA, Leontiadis GI et al. A meta-analysis of the yield of capsule endoscopy compared to other diagnostic modalities in patients with non-stricturing small bowel Crohn's disease. Am J Gastroenterol 2006; 101: 954-964
    CrossrefPubMedGoogle Scholar
  • 93 Rosa B, Moreira MJ, Rebelo A et al. Lewis Score: a useful clinical tool for patients with suspected Crohn's Disease submitted to capsule endoscopy. Journal of Crohn's & colitis 2012; 6: 692-697
    PubMedGoogle Scholar
  • 94 Mergener K, Ponchon T, Gralnek I et al. Literature review and recommendations for clinical application of small-bowel capsule endoscopy, based on a panel discussion by international experts. Consensus statements for small-bowel capsule endoscopy, 2006/2007. Endoscopy 2007; 39: 895-909
    Article in Thieme ConnectPubMedGoogle Scholar
  • 95 Postgate AJ, Burling D, Gupta A et al. Safety, reliability and limitations of the given patency capsule in patients at risk of capsule retention: a 3-year technical review. Dig Dis Sci 2008; 53: 2732-2738
    CrossrefPubMedGoogle Scholar
  • 96 Cheifetz AS, Kornbluth AA, Legnani P et al. The risk of retention of the capsule endoscope in patients with known or suspected Crohn's disease. Am J Gastroenterol 2006; 101: 2218-2222
    CrossrefPubMedGoogle Scholar
  • 97 Liao Z, Gao R, Xu C et al. Indications and detection, completion, and retention rates of small-bowel capsule endoscopy: a systematic review. Gastrointest Endosc 2010; 71: 280-286
    CrossrefPubMedGoogle Scholar
  • 98 Hoog CM, Bark LA, Arkani J et al. Capsule retentions and incomplete capsule endoscopy examinations: an analysis of 2300 examinations. Gastroenterology research and practice 2012; 2012: 518718
    PubMedGoogle Scholar
  • 99 Vernier-Massouille G, Balde M, Salleron J et al. Natural history of pediatric Crohn's disease: a population-based cohort study. Gastroenterology 2008; 135: 1106-1113
    CrossrefPubMedGoogle Scholar
  • 100 Cosnes J, Gower-Rousseau C, Seksik P et al. Epidemiology and natural history of inflammatory bowel diseases. Gastroenterology 2011; 140: 1785-1794
    CrossrefPubMedGoogle Scholar
  • 101 Heine GD, Hadithi M, Groenen MJ et al. Double-balloon enteroscopy: indications, diagnostic yield, and complications in a series of 275 patients with suspected small-bowel disease. Endoscopy 2006; 38: 42-48
    Article in Thieme ConnectPubMedGoogle Scholar
  • 102 Gay G, Delvaux M. Double balloon enteroscopy in Crohn's disease and related disorders: our experience. Gastrointest Endosc 2007; 66: S82-S90
    CrossrefPubMedGoogle Scholar
  • 103 Manes G, Imbesi V, Ardizzone S et al. Use of double-balloon enteroscopy in the management of patients with Crohn's disease: feasibility and diagnostic yield in a high-volume centre for inflammatory bowel disease. Surg Endosc 2009; 23: 2790-2795
    CrossrefPubMedGoogle Scholar
  • 104 Di Nardo G, Oliva S, Aloi M et al. Usefulness of single-balloon enteroscopy in pediatric Crohn's disease. Gastrointest Endosc 2012; 75: 80-86
    CrossrefPubMedGoogle Scholar
  • 105 Despott EJ, Gupta A, Burling D et al. Effective dilation of small-bowel strictures by double-balloon enteroscopy in patients with symptomatic Crohn's disease (with video). Gastrointest Endosc 2009; 70: 1030-1036
    CrossrefPubMedGoogle Scholar
  • 106 Pohl J, May A, Nachbar L et al. Diagnostic and therapeutic yield of push-and-pull enteroscopy for symptomatic small bowel Crohn's disease strictures. Eur J Gastroenterol Hepatol 2007; 19: 529-534
    CrossrefPubMedGoogle Scholar
  • 107 Roseth AG, Aadland E, Jahnsen J et al. Assessment of disease activity in ulcerative colitis by faecal calprotectin, a novel granulocyte marker protein. Digestion 1997; 58: 176-180
    CrossrefPubMedGoogle Scholar
  • 108 Roseth AG, Schmidt PN, Fagerhol MK. Correlation between faecal excretion of indium-111-labelled granulocytes and calprotectin, a granulocyte marker protein, in patients with inflammatory bowel disease. Scand J Gastroenterol 1999; 34: 50-54
    CrossrefPubMedGoogle Scholar
  • 109 Walker TR, Land ML, Kartashov A et al. Fecal lactoferrin is a sensitive and specific marker of disease activity in children and young adults with inflammatory bowel disease. J Pediatr Gastroenterol Nutr 2007; 44: 414-422
    CrossrefPubMedGoogle Scholar
  • 110 Joishy M, Davies I, Ahmed M et al. Fecal calprotectin and lactoferrin as noninvasive markers of pediatric inflammatory bowel disease. J Pediatr Gastroenterol Nutr 2009; 48: 48-54
    CrossrefPubMedGoogle Scholar
  • 111 Quail MA, Russell RK, Van Limbergen JE et al. Fecal calprotectin complements routine laboratory investigations in diagnosing childhood inflammatory bowel disease. Inflamm Bowel Dis 2009; 15: 756-759
    CrossrefPubMedGoogle Scholar
  • 112 D'Inca R, Dal PontE, Di Leo V et al. Can calprotectin predict relapse risk in inflammatory bowel disease?. Am J Gastroenterol 2008; 103: 2007-2014
    CrossrefPubMedGoogle Scholar
  • 113 Tibble JA, Sigthorsson G, Bridger S et al. Surrogate markers of intestinal inflammation are predictive of relapse in patients with inflammatory bowel disease. Gastroenterology 2000; 119: 15-22
    CrossrefPubMedGoogle Scholar
  • 114 Costa F, Mumolo MG, Ceccarelli L et al. Calprotectin is a stronger predictive marker of relapse in ulcerative colitis than in Crohn's disease. Gut 2005; 54: 364-368
    CrossrefPubMedGoogle Scholar
  • 115 Weber P, Koch M, Heizmann WR et al. Microbic superinfection in relapse of inflammatory bowel disease. J Clin Gastroenterol 1992; 14: 302-308
    CrossrefPubMedGoogle Scholar
  • 116 Rolny P, Jarnerot G, Mollby R. Occurrence of Clostridium difficile tox-in in inflammatory bowel disease. Scand J Gastroenterol 1983; 18: 61-64
    CrossrefPubMedGoogle Scholar
  • 117 Johal SS, Hammond J, Solomon K et al. Clostridium difficile associated diarrhoea in hospitalised patients: onset in the community and hospital and role of flexible sigmoidoscopy. Gut 2004; 53: 673-677
    CrossrefPubMedGoogle Scholar
  • 118 Fraquelli M, Colli A, Casazza G et al. Role of US in detection of Crohn disease: meta-analysis. Radiology 2005; 236: 95-101
    CrossrefPubMedGoogle Scholar
  • 119 Bremner AR, Griffiths M, Argent JD et al. Sonographic evaluation of inflammatory bowel disease: a prospective, blinded, comparative study. Pediatr Radiol 2006; 36: 947-953
    CrossrefPubMedGoogle Scholar
  • 120 Maconi G, Parente F, Bollani S et al. Abdominal ultrasound in the assessment of extent and activity of Crohn's disease: clinical significance and implication of bowel wall thickening. Am J Gastroenterol 1996; 91: 1604-1609
    PubMedGoogle Scholar
  • 121 Neye H, Voderholzer W, Rickes S et al. Evaluation of criteria for the activity of Crohn's disease by power Doppler sonography. Dig Dis 2004; 22: 67-72
    CrossrefPubMedGoogle Scholar
  • 122 Ripolles T, Martinez MJ, Paredes JM et al. Crohn disease: correlation of findings at contrast-enhanced US with severity at endoscopy. Radiology 2009; 253: 241-248
    CrossrefPubMedGoogle Scholar
  • 123 Parente F, Maconi G, Bollani S et al. Bowel ultrasound in assessment of Crohn's disease and detection of related small bowel strictures: a prospective comparative study versus × ray and intraoperative findings. Gut 2002; 50: 490-495
    CrossrefPubMedGoogle Scholar
  • 124 Futagami Y, Haruma K, Hata J et al. Development and validation of an ultrasonographic activity index of Crohn's disease. Eur J Gastroenterol Hepatol 1999; 11: 1007-1012
    CrossrefPubMedGoogle Scholar
  • 125 Haber HP, Busch A, Ziebach R et al. Ultrasonographic findings correspond to clinical, endoscopic, and histologic findings in inflammatory bowel disease and other enterocolitides. J Ultrasound Med 2002; 21: 375-382
    PubMedGoogle Scholar
  • 126 Baert F, Moortgat L, Van Assche G et al. Mucosal healing predicts sustained clinical remission in patients with early-stage Crohn's disease. Gastroenterology 2010; 138: 463-468 ; quiz e410-461
    CrossrefPubMedGoogle Scholar
  • 127 Schnitzler F, Fidder H, Ferrante M et al. Mucosal healing predicts long-term outcome of maintenance therapy with infliximab in Crohn's disease. Inflamm Bowel Dis 2009; 15: 1295-1301
    CrossrefPubMedGoogle Scholar
  • 128 Modigliani R, Mary JY, Simon JF et al. Clinical, biological, and endoscopic picture of attacks of Crohn's disease. Evolution on prednisolone. Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives. Gastroenterology 1990; 98: 811-818
    CrossrefPubMedGoogle Scholar
  • 129 Mantzaris GJ, Christidou A, Sfakianakis M et al. Azathioprine is superior to budesonide in achieving and maintaining mucosal healing and histologic remission in steroid-dependent Crohn's disease. Inflamm Bowel Dis 2009; 15: 375-382
    CrossrefPubMedGoogle Scholar
  • 130 van Dullemen HM, van Deventer SJ, Hommes DW et al. Treatment of Crohn's disease with anti-tumor necrosis factor chimeric monoclonal antibody (cA2). Gastroenterology 1995; 109: 129-135
    CrossrefPubMedGoogle Scholar
  • 131 Rutgeerts P, Feagan BG, Lichtenstein GR et al. Comparison of scheduled and episodic treatment strategies of infliximab in Crohn's disease. Gastroenterology 2004; 126: 402-413
    CrossrefPubMedGoogle Scholar
  • 132 Hebuterne X, Lemann M, Bouhnik Y et al. Endoscopic improvement of mucosal lesions in patients with moderate to severe ileocolonic Crohn's disease following treatment with certolizumab pegol. Gut 2013; 62: 201-208
    CrossrefPubMedGoogle Scholar
  • 133 Rutgeerts P, Van Assche G, Sandborn WJ et al. Adalimumab induces and maintains mucosal healing in patients with Crohn's disease: data from the EXTEND trial. Gastroenterology 2012; 142: 1102-1111 e1102
    CrossrefPubMedGoogle Scholar
  • 134 Colombel JF, Sandborn WJ, Reinisch W et al. Infliximab, azathioprine, or combination therapy for Crohn's disease. The New England journal of medicine 2010; 362: 1383-1395
    CrossrefPubMedGoogle Scholar
  • 135 Froslie KF, Jahnsen J, Moum BA et al. Mucosal healing in inflammatory bowel disease: results from a Norwegian population-based cohort. Gastroenterology 2007; 133: 412-422
    CrossrefPubMedGoogle Scholar
  • 136 Rutgeerts P, Diamond RH, Bala M et al. Scheduled maintenance treatment with infliximab is superior to episodic treatment for the healing of mucosal ulceration associated with Crohn's disease. Gastrointest Endosc 2006; 63: 433-442 ; quiz 464
    CrossrefPubMedGoogle Scholar
  • 137 Louis E, Mary JY, Vernier-Massouille G et al. Maintenance of remission among patients with Crohn's disease on antimetabolite therapy after infliximab therapy is stopped. Gastroenterology 2012; 142: 63-70 e65 ; quiz e31
    CrossrefPubMedGoogle Scholar
  • 138 de Bie CI, Buderus S, Sandhu BK et al. Diagnostic workup of paediatric patients with inflammatory bowel disease in Europe: results of a 5-year audit of the EUROKIDS registry. J Pediatr Gastroenterol Nutr 2012; 54: 374-380
    CrossrefPubMedGoogle Scholar
  • 139 Heyman MB, Kirschner BS, Gold BD et al. Children with early-onset inflammatory bowel disease (IBD): analysis of a pediatric IBD consortium registry. J Pediatr 2005; 146: 35-40
    CrossrefPubMedGoogle Scholar
  • 140 Ruuska T, Vaajalahti P, Arajarvi P et al. Prospective evaluation of upper gastrointestinal mucosal lesions in children with ulcerative colitis and Crohn's disease. J Pediatr Gastroenterol Nutr 1994; 19: 181-186
    CrossrefPubMedGoogle Scholar
  • 141 Tobin JM, Sinha B, Ramani P et al. Upper gastrointestinal mucosal disease in pediatric Crohn disease and ulcerative colitis: a blinded, controlled study. J Pediatr Gastroenterol Nutr 2001; 32: 443-448
    CrossrefPubMedGoogle Scholar
  • 142 Abdullah BA, Gupta SK, Croffie JM et al. The role of esophagogastroduodenoscopy in the initial evaluation of childhood inflammatory bowel disease: a 7-year study. J Pediatr Gastroenterol Nutr 2002; 35: 636-640
    CrossrefPubMedGoogle Scholar
  • 143 Castellaneta SP, Afzal NA, Greenberg M et al. Diagnostic role of upper gastrointestinal endoscopy in pediatric inflammatory bowel disease. J Pediatr Gastroenterol Nutr 2004; 39: 257-261
    CrossrefPubMedGoogle Scholar
  • 144 Lemberg DA, Clarkson CM, Bohane TD et al. Role of esophagogastroduodenoscopy in the initial assessment of children with inflammatory bowel disease. J Gastroenterol Hepatol 2005; 20: 1696-1700
    CrossrefPubMedGoogle Scholar
  • 145 Bunn SK, Bisset WM, Main MJ et al. Fecal calprotectin as a measure of disease activity in childhood inflammatory bowel disease. J Pediatr Gastroenterol Nutr 2001; 32: 171-177
    CrossrefPubMedGoogle Scholar
  • 146 Bunn SK, Bisset WM, Main MJ et al. Fecal calprotectin: validation as a noninvasive measure of bowel inflammation in childhood inflammatory bowel disease. J Pediatr Gastroenterol Nutr 2001; 33: 14-22
    CrossrefPubMedGoogle Scholar
  • 147 Fagerberg UL, Loof L, Lindholm J et al. Fecal calprotectin: a quantitative marker of colonic inflammation in children with inflammatory bowel disease. J Pediatr Gastroenterol Nutr 2007; 45: 414-420
    CrossrefPubMedGoogle Scholar
  • 148 Canani RB, de Horatio LT, Terrin G et al. Combined use of noninvasive tests is useful in the initial diagnostic approach to a child with suspected inflammatory bowel disease. J Pediatr Gastroenterol Nutr 2006; 42: 9-15
    CrossrefPubMedGoogle Scholar
  • 149 Henderson P, Casey A, Lawrence SJ et al. The diagnostic accuracy of fecal calprotectin during the investigation of suspected pediatric inflammatory bowel disease. Am J Gastroenterol 2012; 107: 941-949
    CrossrefPubMedGoogle Scholar
  • 150 Van de Vijver E, Schreuder AB, Cnossen WR et al. Safely ruling out inflammatory bowel disease in children and teenagers without referral for endoscopy. Arch Dis Child 2012; 97: 1014-1018
    CrossrefPubMedGoogle Scholar
  • 151 Chen CC, Huang JL, Chang CJ et al. Fecal calprotectin as a correlative marker in clinical severity of infectious diarrhea and usefulness in evaluating bacterial or viral pathogens in children. J Pediatr Gastroenterol Nutr 2012; 55: 541-547
    CrossrefPubMedGoogle Scholar
  • 152 Rutgeerts P, Geboes K, Vantrappen G et al. Predictability of the postoperative course of Crohn's disease. Gastroenterology 1990; 99: 956-963
    CrossrefPubMedGoogle Scholar
  • 153 Rutgeerts P, Van Assche G, Vermeire S et al. Ornidazole for prophylaxis of postoperative Crohn's disease recurrence: a randomized, double-blind, placebo-controlled trial. Gastroenterology 2005; 128: 856-861
    CrossrefPubMedGoogle Scholar
  • 154 Peyrin-Biroulet L, Deltenre P, Ardizzone S et al. Azathioprine and 6-mercaptopurine for the prevention of postoperative recurrence in Crohn's disease: a meta-analysis. Am J Gastroenterol 2009; 104: 2089-2096
    CrossrefPubMedGoogle Scholar
  • 155 Regueiro M, Schraut W, Baidoo L et al. Infliximab prevents Crohn's disease recurrence after ileal resection. Gastroenterology 2009; 136: 441-450 e441 ; quiz 716
    CrossrefPubMedGoogle Scholar
  • 156 Parente F, Sampietro GM, Molteni M et al. Behaviour of the bowel wall during the first year after surgery is a strong predictor of symptomatic recurrence of Crohn's disease: a prospective study. Aliment Pharmacol Ther 2004; 20: 959-968
    CrossrefPubMedGoogle Scholar
  • 157 Castiglione F, Bucci L, Pesce G et al. Oral contrast-enhanced sonography for the diagnosis and grading of postsurgical recurrence of Crohn's disease. Inflamm Bowel Dis 2008; 14: 1240-1245
    CrossrefPubMedGoogle Scholar
  • 158 Castiglione F, de Sio I, Cozzolino A et al. Bowel wall thickness at abdominal ultrasound and the one-year-risk of surgery in patients with Crohn's disease. Am J Gastroenterol 2004; 99: 1977-1983
    CrossrefPubMedGoogle Scholar
  • 159 Maconi G, Sampietro GM, Cristaldi M et al. Preoperative characteristics and postoperative behavior of bowel wall on risk of recurrence after conservative surgery in Crohn's disease: a prospective study. Ann Surg 2001; 233: 345-352
    CrossrefPubMedGoogle Scholar
  • 160 Calabrese E, Petruzziello C, Onali S et al. Severity of postoperative recurrence in Crohn's disease: correlation between endoscopic and sonographic findings. Inflamm Bowel Dis 2009; 15: 1635-1642
    CrossrefPubMedGoogle Scholar
  • 161 Pallotta N, Giovannone M, Pezzotti P et al. Ultrasonographic detection and assessment of the severity of Crohn's disease recurrence after ileal resection. BMC gastroenterology 2010; 10: 69
    CrossrefPubMedGoogle Scholar
  • 162 Sailer J, Peloschek P, Reinisch W et al. Anastomotic recurrence of Crohn's disease after ileocolic resection: comparison of MR enteroclysis with endoscopy. Eur Radiol 2008; 18: 2512-2521
    CrossrefPubMedGoogle Scholar
  • 163 Koilakou S, Sailer J, Peloschek P et al. Endoscopy and MR enteroclysis: equivalent tools in predicting clinical recurrence in patients with Crohn's disease after ileocolic resection. Inflamm Bowel Dis 2010; 16: 198-203
    CrossrefPubMedGoogle Scholar
  • 164 Soyer P, Boudiaf M, Sirol M et al. Suspected anastomotic recurrence of Crohn disease after ileocolic resection: evaluation with CT enteroclysis. Radiology 2010; 254: 755-764
    CrossrefPubMedGoogle Scholar
  • 165 Biancone L, Fiori R, Tosti C et al. Virtual colonoscopy compared with conventional colonoscopy for stricturing postoperative recurrence in Crohn's disease. Inflamm Bowel Dis 2003; 9: 343-350
    CrossrefPubMedGoogle Scholar
  • 166 Surawicz CM, Belic L. Rectal biopsy helps to distinguish acute self-limited colitis from idiopathic inflammatory bowel disease. Gastroenterology 1984; 86: 104-113
    PubMedGoogle Scholar
  • 167 Tanaka M, Masuda T, Yao T et al. Observer variation of diagnoses based on simple biopsy criteria differentiating among Crohn's disease, ulcerative colitis, and other forms of colitis. J Gastroenterol Hepatol 2001; 16: 1368-1372
    CrossrefPubMedGoogle Scholar
  • 168 Tanaka M, Riddell RH, Saito H et al. Morphologic criteria applicable to biopsy specimens for effective distinction of inflammatory bowel disease from other forms of colitis and of Crohn's disease from ulcerative colitis. Scand J Gastroenterol 1999; 34: 55-67
    CrossrefPubMedGoogle Scholar
  • 169 Tanaka M, Saito H, Fukuda S et al. Simple mucosal biopsy criteria differentiating among Crohn disease, ulcerative colitis, and other forms of colitis: measurement of validity. Scand J Gastroenterol 2000; 35: 281-286
    CrossrefPubMedGoogle Scholar
  • 170 Theodossi A, Spiegelhalter DJ, Jass J et al. Observer variation and discriminatory value of biopsy features in inflammatory bowel disease. Gut 1994; 35: 961-968
    CrossrefPubMedGoogle Scholar
  • 171 Schumacher G, Kollberg B, Sandstedt B. A prospective study of first attacks of inflammatory bowel disease and infectious colitis. Histologic course during the 1st year after presentation. Scand J Gastroenterol 1994; 29: 318-332
    CrossrefPubMedGoogle Scholar
  • 172 Jenkins D, Balsitis M, Gallivan S et al. Guidelines for the initial biopsy diagnosis of suspected chronic idiopathic inflammatory bowel disease. The British Society of Gastroenterology Initiative. J Clin Pathol 1997; 50: 93-105
    CrossrefPubMedGoogle Scholar
  • 173 Nostrant TT, Kumar NB, Appelman HD. Histopathology differentiates acute self-limited colitis from ulcerative colitis. Gastroenterology 1987; 92: 318-328
    PubMedGoogle Scholar
  • 174 van Bodegraven AA, Sloots CE, Felt-Bersma RJ et al. Endosonographic evidence of persistence of Crohn's disease-associated fistulas after infliximab treatment, irrespective of clinical response. Dis Colon Rectum 2002; 45: 39-45 ; discussion 45-36
    CrossrefPubMedGoogle Scholar
  • 175 Sloots CE, Felt-Bersma RJ, Poen AC et al. Assessment and classification of fistula-in-ano in patients with Crohn's disease by hydrogen peroxide enhanced transanal ultrasound. Int J Colorectal Dis 2001; 16: 292-297
    CrossrefPubMedGoogle Scholar
  • 176 Orsoni P, Barthet M, Portier F et al. Prospective comparison of endosonography, magnetic resonance imaging and surgical findings in anorectal fistula and abscess complicating Crohn's disease. Br J Surg 1999; 86: 360-364
    CrossrefPubMedGoogle Scholar
  • 177 Schwartz DA, Wiersema MJ, Dudiak KM et al. A comparison of endoscopic ultrasound, magnetic resonance imaging, and exam under anesthesia for evaluation of Crohn's perianal fistulas. Gastroenterology 2001; 121: 1064-1072
    CrossrefPubMedGoogle Scholar
  • 178 Schwartz DA, White CM, Wise PE et al. Use of endoscopic ultrasound to guide combination medical and surgical therapy for patients with Crohn's perianal fistulas. Inflamm Bowel Dis 2005; 11: 727-732
    CrossrefPubMedGoogle Scholar
  • 179 Buchanan GN, Bartram CI, Williams AB et al. Value of hydrogen peroxide enhancement of three-dimensional endoanal ultrasound in fistula-in-ano. Dis Colon Rectum 2005; 48: 141-147
    CrossrefPubMedGoogle Scholar
  • 180 West RL, van der Woude CJ, Hansen BE et al. Clinical and endosonographic effect of ciprofloxacin on the treatment of perianal fistulae in Crohn's disease with infliximab: a double-blind placebo-controlled study. Aliment Pharmacol Ther 2004; 20: 1329-1336
    CrossrefPubMedGoogle Scholar
  • 181 Ardizzone S, Maconi G, Colombo E et al. Perianal fistulae following infliximab treatment: clinical and endosonographic outcome. Inflamm Bowel Dis 2004; 10: 91-96
    CrossrefPubMedGoogle Scholar
  • 182 Wedemeyer J, Kirchhoff T, Manns MP et al. Transcutaneous perianal ultrasound (PAUS) for the imaging of fistulas and abscesses in Crohn's disease. Z Gastroenterol 2004; 42: 1315-1320
    Article in Thieme ConnectPubMedGoogle Scholar
  • 183 Stewart LK, McGee J, Wilson SR. Transperineal and transvaginal sonography of perianal inflammatory disease. Am J Roentgenol Am J Roentgenol 2001; 177: 627-632
    PubMedGoogle Scholar
  • 184 Mallouhi A, Bonatti H, Peer S et al. Detection and characterization of perianal inflammatory disease: accuracy of transperineal combined gray scale and color Doppler sonography. Journal of ultrasound in medicine 2004; 23: 19-27
    PubMedGoogle Scholar
  • 185 Parks AG, Gordon PH, Hardcastle JD. A classification of fistula-in-ano. Br J Surg 1976; 63: 1-12
    CrossrefPubMedGoogle Scholar
  • 186 Bell SJ, Williams AB, Wiesel P et al. The clinical course of fistulating Crohn's disease. Aliment Pharmacol Ther 2003; 17: 1145-1151
    CrossrefPubMedGoogle Scholar
  • 187 Thornton M, Solomon MJ. Long-term indwelling seton for complex anal fistulas in Crohn's disease. Dis Colon Rectum 2005; 48: 459-463
    CrossrefPubMedGoogle Scholar
  • 188 Rasul I, Wilson SR, MacRae H et al. Clinical and radiological responses after infliximab treatment for perianal fistulizing Crohn's disease. Am J Gastroenterol 2004; 99: 82-88
    CrossrefPubMedGoogle Scholar
  • 189 Sandborn WJ, Fazio VW, Feagan BG et al. AGA technical review on perianal Crohn's disease. Gastroenterology 2003; 125: 1508-1530
    CrossrefPubMedGoogle Scholar
  • 190 Seldenrijk CA, Morson BC, Meuwissen SG et al. Histopathological evaluation of colonic mucosal biopsy specimens in chronic inflammatory bowel disease: diagnostic implications. Gut 1991; 32: 1514-1520
    CrossrefPubMedGoogle Scholar
  • 191 Mowat C, Cole A, Windsor A et al. Guidelines for the management of inflammatory bowel disease in adults. Gut 2011; 60: 571-607
    CrossrefPubMedGoogle Scholar
  • 192 Petritsch W, Feichtenschlager T, Gasche C et al. Diagnosis in chronic inflammatory bowel diseases--report of the Austrian Chronic Inflammatory Bowel Disease Study Group. Acta medica Austriaca 1998; 25: 37-43
    PubMedGoogle Scholar
  • 193 Surawicz CM, Meisel JL, Ylvisaker T et al. Rectal biopsy in the diagnosis of Crohn's disease: value of multiple biopsies and serial sectioning. Gastroenterology 1981; 80: 66-71
    PubMedGoogle Scholar
  • 194 Dejaco C, Oesterreicher C, Angelberger S et al. Diagnosing colitis: a prospective study on essential parameters for reaching a diagnosis. Endoscopy 2003; 35: 1004-1008
    Article in Thieme ConnectPubMedGoogle Scholar
  • 195 Bentley E, Jenkins D, Campbell F et al. How could pathologists improve the initial diagnosis of colitis? Evidence from an international workshop. J Clin Pathol 2002; 55: 955-960
    CrossrefPubMedGoogle Scholar
  • 196 Geboes K, Ectors N, D'Haens G et al. Is ileoscopy with biopsy worthwhile in patients presenting with symptoms of inflammatory bowel disease?. Am J Gastroenterol 1998; 93: 201-206
    CrossrefPubMedGoogle Scholar
  • 197 McHugh JB, Appelman HD, McKenna BJ. The diagnostic value of endoscopic terminal ileum biopsies. Am J Gastroenterol 2007; 102: 1084-1089
    CrossrefPubMedGoogle Scholar
  • 198 Ectors NL, Dixon MF, Geboes KJ et al. Granulomatous gastritis: a morphological and diagnostic approach. Histopathology 1993; 23: 55-61
    CrossrefPubMedGoogle Scholar
  • 199 Shapiro JL, Goldblum JR, Petras RE. A clinicopathologic study of 42 patients with granulomatous gastritis. Is there really an "idiopathic" granulomatous gastritis?. Am J Surg Pathol 1996; 20: 462-470
    CrossrefPubMedGoogle Scholar
  • 200 Oberhuber G, Puspok A, Oesterreicher C et al. Focally enhanced gastritis: a frequent type of gastritis in patients with Crohn's disease. Gastroenterology 1997; 112: 698-706
    CrossrefPubMedGoogle Scholar
  • 201 Wright CL, Riddell RH. Histology of the stomach and duodenum in Crohn's disease. Am J Surg Pathol 1998; 22: 383-390
    CrossrefPubMedGoogle Scholar
  • 202 Parente F, Cucino C, Bollani S et al. Focal gastric inflammatory infiltrates in inflammatory bowel diseases: prevalence, immunohistochemical characteristics, and diagnostic role. Am J Gastroenterol 2000; 95: 705-711
    CrossrefPubMedGoogle Scholar
  • 203 Vilela EG, Torres HO, Martins FP et al. Evaluation of inflammatory activity in Crohn's disease and ulcerative colitis. World J Gastroenterol 2012; 18: 872-881
    CrossrefPubMedGoogle Scholar
  • 204 Korelitz BI, Sommers SC. Response to drug therapy in Crohn's disease: evaluation by rectal biopsy and mucosal cell counts. J Clin Gastroenterol 1984; 6: 123-127
    CrossrefPubMedGoogle Scholar
  • 205 Nicholls S, Domizio P, Williams CB et al. Cyclosporin as initial treatment for Crohn's disease. Arch Dis Child 1994; 71: 243-247
    CrossrefPubMedGoogle Scholar
  • 206 Beattie RM, Schiffrin EJ, Donnet-Hughes A et al. Polymeric nutrition as the primary therapy in children with small bowel Crohn's disease. Aliment Pharmacol Ther 1994; 8: 609-615
    PubMedGoogle Scholar
  • 207 D'Haens G, Geboes K, Ponette E et al. Healing of severe recurrent ileitis with azathioprine therapy in patients with Crohn's disease. Gastroenterology 1997; 112: 1475-1481
    CrossrefPubMedGoogle Scholar
  • 208 D'Haens G, Van Deventer S, Van Hogezand R et al. Endoscopic and histological healing with infliximab anti-tumor necrosis factor antibodies in Crohn's disease: A European multicenter trial. Gastroenterology 1999; 116: 1029-1034
    CrossrefPubMedGoogle Scholar
  • 209 Fell JM, Paintin M, Arnaud-Battandier F et al. Mucosal healing and a fall in mucosal pro-inflammatory cytokine mRNA induced by a specific oral polymeric diet in paediatric Crohn's disease. Aliment Pharmacol Ther 2000; 14: 281-289
    CrossrefPubMedGoogle Scholar
  • 210 Wright R, Truelove SR. Serial rectal biopsy in ulcerative colitis during the course of a controlled therapeutic trial of various diets. The American journal of digestive diseases 1966; 11: 847-857
    CrossrefPubMedGoogle Scholar
  • 211 Bataille F, Klebl F, Rummele P et al. Histopathological parameters as predictors for the course of Crohn's disease. Virchows Arch 2003; 443: 501-507
    CrossrefPubMedGoogle Scholar
  • 212 Bernstein CN, Fried M, Krabshuis JH et al. World Gastroenterology Organization Practice Guidelines for the diagnosis and management of IBD in 2010. Inflamm Bowel Dis 2010; 16: 112-124
    CrossrefPubMedGoogle Scholar
  • 213 Turner D, Travis SP, Griffiths AM et al. Consensus for managing acute severe ulcerative colitis in children: a systematic review and joint statement from ECCO, ESPGHAN, and the Porto IBD Working Group of ESPGHAN. Am J Gastroenterol 2011; 106: 574-588
    CrossrefPubMedGoogle Scholar
  • 214 Cross SS, Harrison RF. Discriminant histological features in the diagnosis of chronic idiopathic inflammatory bowel disease: analysis of a large dataset by a novel data visualisation technique. J Clin Pathol 2002; 55: 51-57
    CrossrefPubMedGoogle Scholar
  • 215 Levine A. Pediatric inflammatory bowel disease: is it different?. Dig Dis 2009; 27: 212-214
    CrossrefPubMedGoogle Scholar
  • 216 Bernstein CN, Blanchard JF, Kliewer E et al. Cancer risk in patients with inflammatory bowel disease: a population-based study. Cancer 2001; 91: 854-862
    CrossrefPubMedGoogle Scholar
  • 217 Jess T, Gamborg M, Matzen P et al. Increased risk of intestinal cancer in Crohn's disease: a meta-analysis of population-based cohort studies. Am J Gastroenterol 2005; 100: 2724-2729
    CrossrefPubMedGoogle Scholar
  • 218 Canavan C, Abrams KR, Mayberry J. Meta-analysis: colorectal and small bowel cancer risk in patients with Crohn's disease. Aliment Pharmacol Ther 2006; 23: 1097-1104
    CrossrefPubMedGoogle Scholar
  • 219 Rubio CA, Dick Jr EJ, Orrego A et al. Further studies on the frequency and length of the glandulo-metaplastic esophageal mucosa in baboons. In Vivo 2009; 23: 955-958
    PubMedGoogle Scholar
  • 220 Laukoetter MG, Mennigen R, Hannig CM et al. Intestinal cancer risk in Crohn's disease: a meta-analysis. J Gastrointest Surg 2011; 15: 576-583
    CrossrefPubMedGoogle Scholar
  • 221 Maykel JA, Hagerman G, Mellgren AF et al. Crohn's colitis: the incidence of dysplasia and adenocarcinoma in surgical patients. Dis Colon Rectum 2006; 49: 950-957
    CrossrefPubMedGoogle Scholar
  • 222 Bergeron V, Vienne A, Sokol H et al. Risk factors for neoplasia in inflammatory bowel disease patients with pancolitis. Am J Gastroenterol 2010; 105: 2405-2411
    CrossrefPubMedGoogle Scholar
  • 223 Palascak-Juif V, Bouvier AM, Cosnes J et al. Small bowel adenocarcinoma in patients with Crohn's disease compared with small bowel adenocarcinoma de novo. Inflamm Bowel Dis 2005; 11: 828-832
    CrossrefPubMedGoogle Scholar
  • 224 Feldstein RC, Sood S, Katz S. Small bowel adenocarcinoma in Crohn's disease. Inflamm Bowel Dis 2008; 14: 1154-1157
    CrossrefPubMedGoogle Scholar
  • 225 Rubin CE, Haggitt RC, Burmer GC et al. DNA aneuploidy in colonic biopsies predicts future development of dysplasia in ulcerative colitis. Gastroenterology 1992; 103: 1611-1620
    PubMedGoogle Scholar
  • 226 Friedman S, Rubin PH, Bodian C et al. Screening and surveillance colonoscopy in chronic Crohn's colitis: results of a surveillance program spanning 25 years. Clin Gastroenterol Hepatol 2008; 6: 993-998; quiz 953 – 994
    CrossrefPubMedGoogle Scholar
  • 227 National Institute for Health and Clinical Excellence. Colonoscopic surveillance for prevention of colorectal cancer in people with ulcerative colitis, Crohn’s disease or adenomas. CG118. London: National Institute for Health and Clinical Excellence; 2011
    PubMedGoogle Scholar
  • 228 Cairns SR, Scholefield JH, Steele RJ et al. Guidelines for colorectal cancer screening and surveillance in moderate and high risk groups (update from 2002). Gut 2010; 59: 666-689
    CrossrefPubMedGoogle Scholar
  • 229 Farraye FA, Odze RD, Eaden J et al. AGA medical position statement on the diagnosis and management of colorectal neoplasia in inflammatory bowel disease. Gastroenterology 2010; 138: 738-745
    CrossrefPubMedGoogle Scholar
  • 230 Odze RD, Ridell RH, Bosman FT et al. Premalignant lesions of the digestive tract. In: Bosman FT, Carneiro F, Hruban RH, et al, Hrsg. WHO Classification of Tumours of the Digestive System. 4th. Aufl. Lyon (France): IARC Press; 2010: 10-12
    Google Scholar
  • 231 Riddell RH, Goldman H, Ransohoff DF et al. Dysplasia in inflammatory bowel disease: standardized classification with provisional clinical applications. Hum Pathol 1983; 14: 931-968
    CrossrefPubMedGoogle Scholar
  • 232 Vieth M, Behrens H, Stolte M. Sporadic adenoma in ulcerative colitis: endoscopic resection is an adequate treatment. Gut 2006; 55: 1151-1155
    CrossrefPubMedGoogle Scholar
  • 233 Sjoqvist U, Befrits R, Soderlund S et al. Colorectal cancer in colonic Crohn's disease--high frequency of DNA-aneuploidy. Anticancer research 2005; 25: 4393-4397
    PubMedGoogle Scholar
  • 234 Nathanson JW, Yadron NE, Farnan J et al. p53 mutations are associated with dysplasia and progression of dysplasia in patients with Crohn's disease. Dig Dis Sci 2008; 53: 474-480
    CrossrefPubMedGoogle Scholar
  • 235 Summers RW, Switz DM, Sessions Jr JT et al. National Cooperative Crohn's Disease Study: results of drug treatment. Gastroenterology 1979; 77: 847-869
    PubMedGoogle Scholar
  • 236 Singleton JW, Law DH, Kelley Jr ML et al. National Cooperative Crohn's Disease Study: adverse reactions to study drugs. Gastroenterology 1979; 77: 870-882
    PubMedGoogle Scholar
  • 237 Malchow H, Ewe K, Brandes JW et al. European Cooperative Crohn's Disease Study (ECCDS): results of drug treatment. Gastroenterology 1984; 86: 249-266
    PubMedGoogle Scholar
  • 238 Rutgeerts P, Lofberg R, Malchow H et al. A comparison of budesonide with prednisolone for active Crohn's disease. The New England journal of medicine 1994; 331: 842-845
    CrossrefPubMedGoogle Scholar
  • 239 Otley A, Steinhart AH. Budesonide for induction of remission in Crohn's disease. Cochrane Database Syst Rev 2005; DOI CD000296
    PubMedGoogle Scholar
  • 240 Schoon EJ, Bollani S, Mills PR et al. Bone mineral density in relation to efficacy and side effects of budesonide and prednisolone in Crohn's disease. Clin Gastroenterol Hepatol 2005; 3: 113-121
    CrossrefPubMedGoogle Scholar
  • 241 Aberra FN, Lewis JD, Hass D et al. Corticosteroids and immunomodulators: postoperative infectious complication risk in inflammatory bowel disease patients. Gastroenterology 2003; 125: 320-327
    CrossrefPubMedGoogle Scholar
  • 242 Lichtenstein GR, Feagan BG, Cohen RD et al. Serious infection and mortality in patients with Crohn's disease: more than 5 years of follow-up in the TREAT registry. Am J Gastroenterol 2012; 107: 1409-1422
    CrossrefPubMedGoogle Scholar
  • 243 Lichtenstein GR, Feagan BG, Cohen RD et al. Serious infections and mortality in association with therapies for Crohn's disease: TREAT registry. Clin Gastroenterol Hepatol 2006; 4: 621-630
    CrossrefPubMedGoogle Scholar
  • 244 Toruner M, Loftus Jr EV, Harmsen WS et al. Risk factors for opportunistic infections in patients with inflammatory bowel disease. Gastroenterology 2008; 134: 929-936
    CrossrefPubMedGoogle Scholar
  • 245 Fidder H, Schnitzler F, Ferrante M et al. Long-term safety of infliximab for the treatment of inflammatory bowel disease: a single-centre cohort study. Gut 2009; 58: 501-508
    CrossrefPubMedGoogle Scholar
  • 246 Sutherland LR, Ramcharan S, Bryant H et al. Effect of cigarette smoking on recurrence of Crohn's disease. Gastroenterology 1990; 98: 1123-1128
    PubMedGoogle Scholar
  • 247 Munkholm P, Langholz E, Davidsen M et al. Disease activity courses in a regional cohort of Crohn's disease patients. Scand J Gastroenterol 1995; 30: 699-706
    CrossrefPubMedGoogle Scholar
  • 248 Duricova D, Pedersen N, Elkjaer M et al. Overall and cause-specific mortality in Crohn's disease: a meta-analysis of population-based studies. Inflamm Bowel Dis 2010; 16: 347-353
    CrossrefPubMedGoogle Scholar
  • 249 Beaugerie L, Seksik P, Nion-Larmurier I et al. Predictors of Crohn's disease. Gastroenterology 2006; 130: 650-656
    CrossrefPubMedGoogle Scholar
  • 250 Loly C, Belaiche J, Louis E. Predictors of severe Crohn's disease. Scand J Gastroenterol 2008; 43: 948-954
    CrossrefPubMedGoogle Scholar
  • 251 Kruis W, Katalinic A, Klugmann T et al. Predictive factors for an uncomplicated long-term course of Crohn's disease: a retrospective analysis. Journal of Crohn's & colitis 2013; 7: e263-e270
    PubMedGoogle Scholar
  • 252 Cosnes J, Bourrier A, Laharie D et al. Early administration of azathioprine vs conventional management of Crohn's Disease: a randomized controlled trial. Gastroenterology 2013; 145: 758-765
    CrossrefPubMedGoogle Scholar
  • 253 Panes J, Lopez-Sanroman A, Bermejo F et al. Early azathioprine therapy is no more effective than placebo for newly diagnosed Crohn's disease. Gastroenterology 2013; 145: 766-774 e761
    CrossrefPubMedGoogle Scholar
  • 254 Marks DJ, Harbord MW, MacAllister R et al. Defective acute inflammation in Crohn's disease: a clinical investigation. Lancet 2006; 367: 668-678
    CrossrefPubMedGoogle Scholar
  • 255 Xavier RJ, Podolsky DK. Unravelling the pathogenesis of inflammatory bowel disease. Nature 2007; 448: 427-434
    CrossrefPubMedGoogle Scholar
  • 256 Dieckgraefe BK, Korzenik JR. Treatment of active Crohn's disease with recombinant human granulocyte-macrophage colony-stimulating factor. Lancet 2002; 360: 1478-1480
    CrossrefPubMedGoogle Scholar
  • 257 Korzenik JR, Dieckgraefe BK, Valentine JF et al. Sargramostim for active Crohn's disease. The New England journal of medicine 2005; 352: 2193-2201
    CrossrefPubMedGoogle Scholar
  • 258 Gavazzi G, Krause KH. Ageing and infection. The Lancet infectious diseases 2002; 2: 659-666
    CrossrefPubMedGoogle Scholar
  • 259 Nikolich-Zugich J. T cell aging: naive but not young. The Journal of experimental medicine 2005; 201: 837-840
    CrossrefPubMedGoogle Scholar
  • 260 Solana R, Pawelec G, Tarazona R. Aging and innate immunity. Immunity 2006; 24: 491-494
    CrossrefPubMedGoogle Scholar
  • 261 Weng NP. Aging of the immune system: how much can the adaptive immune system adapt?. Immunity 2006; 24: 495-499
    CrossrefPubMedGoogle Scholar
  • 262 Colombel JF, Loftus Jr EV, Tremaine WJ et al. The safety profile of infliximab in patients with Crohn's disease: the Mayo clinic experience in 500 patients. Gastroenterology 2004; 126: 19-31
    CrossrefPubMedGoogle Scholar
  • 263 Doran MF, Crowson CS, Pond GR et al. Predictors of infection in rheumatoid arthritis. Arthritis Rheum 2002; 46: 2294-2300
    CrossrefPubMedGoogle Scholar
  • 264 Chandra RK. Nutrition, immunity and infection: from basic knowledge of dietary manipulation of immune responses to practical application of ameliorating suffering and improving survival. Proceedings of the National Academy of Sciences of the United States of America 1996; 93: 14304-14307
    CrossrefPubMedGoogle Scholar
  • 265 Chandra RK. Effect of vitamin and trace-element supplementation on immune responses and infection in elderly subjects. Lancet 1992; 340: 1124-1127
    CrossrefPubMedGoogle Scholar
  • 266 Krok KL, Lichtenstein GR. Nutrition in Crohn disease. Curr Opin Gastroenterol 2003; 19: 148-153
    CrossrefPubMedGoogle Scholar
  • 267 Ainley C, Cason J, Slavin BM et al. The influence of zinc status and malnutrition on immunological function in Crohn's disease. Gastroenterology 1991; 100: 1616-1625
    PubMedGoogle Scholar
  • 268 Yamamoto T, Allan RN, Keighley MR. Risk factors for intra-abdominal sepsis after surgery in Crohn's disease. Dis Colon Rectum 2000; 43: 1141-1145
    CrossrefPubMedGoogle Scholar
  • 269 Crum NF, Lederman ER, Wallace MR. Infections associated with tumor necrosis factor-alpha antagonists. Medicine (Baltimore) 2005; 84: 291-302
    CrossrefPubMedGoogle Scholar
  • 270 Gaemperli A, Hauser T, Speck R. Risk of infection during treatment with tumor necrosis factor-alpha inhibitors. Zeitschrift fur Rheumatologie 2006; 65: 24-28, 30-21
    CrossrefPubMedGoogle Scholar
  • 271 Gupta G, Lautenbach E, Lewis JD. Incidence and risk factors for herpes zoster among patients with inflammatory bowel disease. Clin Gastroenterol Hepatol 2006; 4: 1483-1490
    CrossrefPubMedGoogle Scholar
  • 272 Viget N, Vernier-Massouille G, Salmon-Ceron D et al. Opportunistic infections in patients with inflammatory bowel disease: prevention and diagnosis. Gut 2008; 57: 549-558
    PubMedGoogle Scholar
  • 273 Tsiodras S, Samonis G, Boumpas DT et al. Fungal infections complicating tumor necrosis factor alpha blockade therapy. Mayo Clinic proceedings 2008; 83: 181-194
    CrossrefPubMedGoogle Scholar
  • 274 Stuck AE, Minder CE, Frey FJ. Risk of infectious complications in patients taking glucocorticosteroids. Reviews of infectious diseases 1989; 11: 954-963
    CrossrefPubMedGoogle Scholar
  • 275 Jick SS, Lieberman ES, Rahman MU et al. Glucocorticoid use, other associated factors, and the risk of tuberculosis. Arthritis Rheum 2006; 55: 19-26
    CrossrefPubMedGoogle Scholar
  • 276 Yang Z, Wu Q, Wu K et al. Meta-analysis: pre-operative infliximab treatment and short-term post-operative complications in patients with ulcerative colitis. Aliment Pharmacol Ther 2010; 31: 486-492
    CrossrefPubMedGoogle Scholar
  • 277 Schneeweiss S, Setoguchi S, Weinblatt ME et al. Anti-tumor necrosis factor alpha therapy and the risk of serious bacterial infections in elderly patients with rheumatoid arthritis. Arthritis Rheum 2007; 56: 1754-1764
    CrossrefPubMedGoogle Scholar
  • 278 Keane J, Gershon S, Wise RP et al. Tuberculosis associated with infliximab, a tumor necrosis factor alpha-neutralizing agent. The New England journal of medicine 2001; 345: 1098-1104
    CrossrefPubMedGoogle Scholar
  • 279 Bakleh M, Tleyjeh I, Matteson EL et al. Infectious complications of tumor necrosis factor-alpha antagonists. International journal of dermatology 2005; 44: 443-448
    CrossrefPubMedGoogle Scholar
  • 280 Dederichs F, Pinciu F, Gerhard H et al. Listeria meningitis in a patient with Crohn's disease – a seldom, but clinically relevant adverse event of therapy with infliximab. Z Gastroenterol 2006; 44: 657-660
    Article in Thieme ConnectPubMedGoogle Scholar
  • 281 Tiede I, Fritz G, Strand S et al. CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes. The Journal of clinical investigation 2003; 111: 1133-1145
    CrossrefPubMedGoogle Scholar
  • 282 Mackey AC, Green L, Liang LC et al. Hepatosplenic T cell lymphoma associated with infliximab use in young patients treated for inflammatory bowel disease. J Pediatr Gastroenterol Nutr 2007; 44: 265-267
    CrossrefPubMedGoogle Scholar
  • 283 Deepak P, Sifuentes H, Sherid M et al. T-cell non-Hodgkin's lymphomas reported to the FDA AERS with tumor necrosis factor-alpha (TNF-alpha) inhibitors: results of the REFURBISH study. Am J Gastroenterol 2013; 108: 99-105
    CrossrefPubMedGoogle Scholar
  • 284 Beaugerie L, Brousse N, Bouvier AM et al. Lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease: a prospective observational cohort study. Lancet 2009; 374: 1617-1625
    CrossrefPubMedGoogle Scholar
  • 285 Sokol H, Beaugerie L, Maynadie M et al. Excess primary intestinal lymphoproliferative disorders in patients with inflammatory bowel disease. Inflamm Bowel Dis 2012; 18: 2063-2071
    CrossrefPubMedGoogle Scholar
  • 286 Long MD, Kappelman MD, Pipkin CA. Nonmelanoma skin cancer in inflammatory bowel disease: a review. Inflamm Bowel Dis 2011; 17: 1423-1427
    CrossrefPubMedGoogle Scholar
  • 287 Maddox JS, Soltani K. Risk of nonmelanoma skin cancer with azathioprine use. Inflamm Bowel Dis 2008; 14: 1425-1431
    CrossrefPubMedGoogle Scholar
  • 288 Long MD, Martin CF, Pipkin CA et al. Risk of melanoma and nonmelanoma skin cancer among patients with inflammatory bowel disease. Gastroenterology 2012; 143: 390-399 e391
    CrossrefPubMedGoogle Scholar
  • 289 Seow CH, Benchimol EI, Griffiths AM et al. Budesonide for induction of remission in Crohn's disease. Cochrane Database Syst Rev 2008; DOI: 10.1002/14651858.CD000296.pub3. CD000296
    PubMedGoogle Scholar
  • 290 Thomsen OO, Cortot A, Jewell D et al. A comparison of budesonide and mesalamine for active Crohn's disease. International Budesonide-Mesalamine Study Group. The New England journal of medicine 1998; 339: 370-374
    CrossrefPubMedGoogle Scholar
  • 291 Tromm A, Bunganic I, Tomsova E et al. Budesonide 9 mg is at least as effective as mesalamine 4.5g in patients with mildly to moderately active Crohn's disease. Gastroenterology 2011; 140: 425-434 e421; quiz e413-e424
    CrossrefPubMedGoogle Scholar
  • 292 Lim WC, Hanauer S. Aminosalicylates for induction of remission or response in Crohn's disease. Cochrane Database Syst Rev 2010; DOI: 10.1002/14651858.CD008870.
    PubMedGoogle Scholar
  • 293 Ford AC, Kane SV, Khan KJ et al. Efficacy of 5-aminosalicylates in Crohn's disease: systematic review and meta-analysis. Am J Gastroenterol 2011; 106: 617-629
    CrossrefPubMedGoogle Scholar
  • 294 National Institute for Health and Clinical Excellence. Crohn's disease, Management in adults, children and young people. CG152. London: National Institute for Health and Clinical Excellence; 2012
    PubMedGoogle Scholar
  • 295 Su C. Outcomes of placebo therapy in inflammatory bowel disease. Inflamm Bowel Dis 2006; 12: 328-333
    CrossrefPubMedGoogle Scholar
  • 296 Prantera C, Lochs H, Campieri M et al. Antibiotic treatment of Crohn's disease: results of a multicentre, double blind, randomized, placebo-controlled trial with rifaximin. Aliment Pharmacol Ther 2006; 23: 1117-1125
    CrossrefPubMedGoogle Scholar
  • 297 Prantera C, Lochs H, Grimaldi M et al. Rifaximin-extended intestinal release induces remission in patients with moderately active Crohn's disease. Gastroenterology 2012; 142: 473-481 e474
    CrossrefPubMedGoogle Scholar
  • 298 Colombel JF, Lemann M, Cassagnou M et al. A controlled trial comparing ciprofloxacin with mesalazine for the treatment of active Crohn's disease. Groupe d'Etudes Therapeutiques des Affections Inflammatoires Digestives (GETAID). Am J Gastroenterol 1999; 94: 674-678
    CrossrefPubMedGoogle Scholar
  • 299 Goodgame RW, Kimball K, Akram S et al. Randomized controlled trial of clarithromycin and ethambutol in the treatment of Crohn's disease. Aliment Pharmacol Ther 2001; 15: 1861-1866
    CrossrefPubMedGoogle Scholar
  • 300 Sutherland L, Singleton J, Sessions J et al. Double blind, placebo controlled trial of metronidazole in Crohn's disease. Gut 1991; 32: 1071-1075
    CrossrefPubMedGoogle Scholar
  • 301 Ambrose NS, Allan RN, Keighley MR et al. Antibiotic therapy for treatment in relapse of intestinal Crohn's disease. A prospective randomized study. Dis Colon Rectum 1985; 28: 81-85
    CrossrefPubMedGoogle Scholar
  • 302 Blichfeldt P, Blomhoff JP, Myhre E et al. Metronidazole in Crohn's disease. A double blind cross-over clinical trial. Scand J Gastroenterol 1978; 13: 123-127
    CrossrefPubMedGoogle Scholar
  • 303 Arnold GL, Beaves MR, Pryjdun VO et al. Preliminary study of ciprofloxacin in active Crohn's disease. Inflamm Bowel Dis 2002; 8: 10-15
    CrossrefPubMedGoogle Scholar
  • 304 Prantera C, Zannoni F, Scribano ML et al. An antibiotic regimen for the treatment of active Crohn's disease: a randomized, controlled clinical trial of metronidazole plus ciprofloxacin. Am J Gastroenterol 1996; 91: 328-332
    PubMedGoogle Scholar
  • 305 Benchimol E, Seow C, Steinhart A et al. Traditional corticosteroids for induction of remission in Crohn's disease. Cochrane Database Syst Rev 2008; DOI: 10.1002/14651858.CD006792.pub2.
    PubMedGoogle Scholar
  • 306 Steinhart AH, Feagan BG, Wong CJ et al. Combined budesonide and antibiotic therapy for active Crohn's disease: a randomized controlled trial. Gastroenterology 2002; 123: 33-40
    CrossrefPubMedGoogle Scholar
  • 307 Mielants H, Veys EM, Cuvelier C et al. HLA-B27 related arthritis and bowel inflammation. Part 2. Ileocolonoscopy and bowel histology in patients with HLA-B27 related arthritis. The Journal of rheumatology 1985; 12: 294-298
    PubMedGoogle Scholar
  • 308 Herfarth H, Gross V, Andus T et al. Analysis of the therapeutic efficacy of different doses of budesonide in patients with active Crohn's ileocolitis depending on disease activity and localization. Int J Colorectal Dis 2004; 19: 147-152
    CrossrefPubMedGoogle Scholar
  • 309 Kugathasan S, Werlin SL, Martinez A et al. Prolonged duration of response to infliximab in early but not late pediatric Crohn's disease. Am J Gastroenterol 2000; 95: 3189-3194
    CrossrefPubMedGoogle Scholar
  • 310 Lionetti P, Bronzini F, Salvestrini C et al. Response to infliximab is related to disease duration in paediatric Crohn's disease. Aliment Pharmacol Ther 2003; 18: 425-431
    CrossrefPubMedGoogle Scholar
  • 311 Schreiber S, Colombel JF, Bloomfield R et al. Increased response and remission rates in short-duration Crohn's disease with subcutaneous certolizumab pegol: an analysis of PRECiSE 2 randomized maintenance trial data. Am J Gastroenterol 2010; 105: 1574-1582
    CrossrefPubMedGoogle Scholar
  • 312 Fichera A, Lovadina S, Rubin M et al. Patterns and operative treatment of recurrent Crohn's disease: a prospective longitudinal study. Surgery 2006; 140: 649-654
    CrossrefPubMedGoogle Scholar
  • 313 Yamamoto T, Fazio VW, Tekkis PP. Safety and efficacy of strictureplasty for Crohn's disease: a systematic review and meta-analysis. Dis Colon Rectum 2007; 50: 1968-1986
    CrossrefPubMedGoogle Scholar
  • 314 Tremaine WJ. Gastroduodenal Crohn's disease: medical management. Inflamm Bowel Dis 2003; 9: 127-128 ; discussion 131
    CrossrefPubMedGoogle Scholar
  • 315 Mottet C, Juillerat P, Gonvers JJ et al. Treatment of gastroduodenal Crohn's disease. Digestion 2005; 71: 37-40
    CrossrefPubMedGoogle Scholar
  • 316 Miehsler W, Puspok A, Oberhuber T et al. Impact of different therapeutic regimens on the outcome of patients with Crohn's disease of the upper gastrointestinal tract. Inflamm Bowel Dis 2001; 7: 99-105
    CrossrefPubMedGoogle Scholar
  • 317 Targan SR, Hanauer SB, van Deventer SJ et al. A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn's disease. Crohn's Disease cA2 Study Group. The New England journal of medicine 1997; 337: 1029-1035
    CrossrefPubMedGoogle Scholar
  • 318 Colombel JF, Sandborn WJ, Rutgeerts P et al. Adalimumab for maintenance of clinical response and remission in patients with Crohn's disease: the CHARM trial. Gastroenterology 2007; 132: 52-65
    CrossrefPubMedGoogle Scholar
  • 319 Schreiber S, Rutgeerts P, Fedorak RN et al. A randomized, placebo-controlled trial of certolizumab pegol (CDP870) for treatment of Crohn's disease. Gastroenterology 2005; 129: 807-818
    CrossrefPubMedGoogle Scholar
  • 320 Sandborn WJ, Feagan BG, Stoinov S et al. Certolizumab pegol for the treatment of Crohn's disease. The New England journal of medicine 2007; 357: 228-238
    CrossrefPubMedGoogle Scholar
  • 321 Hanauer SB, Feagan BG, Lichtenstein GR et al. Maintenance infliximab for Crohn's disease: the ACCENT I randomised trial. Lancet 2002; 359: 1541-1549
    CrossrefPubMedGoogle Scholar
  • 322 Sandborn WJ, Hanauer SB, Rutgeerts P et al. Adalimumab for maintenance treatment of Crohn's disease: results of the CLASSIC II trial. Gut 2007; 56: 1232-1239
    CrossrefPubMedGoogle Scholar
  • 323 Schreiber S, Khaliq-Kareemi M, Lawrance IC et al. Maintenance therapy with certolizumab pegol for Crohn's disease. The New England journal of medicine 2007; 357: 239-250
    CrossrefPubMedGoogle Scholar
  • 324 Cassinotti A, Travis S. Incidence and clinical significance of immunogenicity to infliximab in Crohn's disease: a critical systematic review. Inflamm Bowel Dis 2009; 15: 1264-1275
    CrossrefPubMedGoogle Scholar
  • 325 Sandborn W, Sutherland L, Pearson D et al. Azathioprine or 6-mercaptopurine for inducing remission of Crohn's disease. Cochrane Database Syst Rev 2000; DOI: CD000545.
    PubMedGoogle Scholar
  • 326 Pearson DC, May GR, Fick G et al. Azathioprine for maintaining remission of Crohn's disease. Cochrane Database Syst Rev 2000; DOI: CD000067.
    PubMedGoogle Scholar
  • 327 Bastida PazG, Nos MateuP, Aguas PerisM et al. Optimization of immunomodulatory treatment with azathioprine or 6-mercaptopurine in inflammatory bowel disease. Gastroenterol Hepatol 2007; 30: 511-516
    CrossrefPubMedGoogle Scholar
  • 328 Alfadhli AA, McDonald JW, Feagan BG. Methotrexate for induction of remission in refractory Crohn's disease. Cochrane Database Syst Rev 2005; DOI: 10.1002/14651858.CD003459.pub2.
    PubMedGoogle Scholar
  • 329 Fraser AG. Methotrexate: first-line or second-line immunomodulator?. Eur J Gastroenterol Hepatol 2003; 15: 225-231
    CrossrefPubMedGoogle Scholar
  • 330 Mack DR, Young R, Kaufman SS et al. Methotrexate in patients with Crohn's disease after 6-mercaptopurine. J Pediatr 1998; 132: 830-835
    CrossrefPubMedGoogle Scholar
  • 331 Uhlen S, Belbouab R, Narebski K et al. Efficacy of methotrexate in pediatric Crohn's disease: a French multicenter study. Inflamm Bowel Dis 2006; 12: 1053-1057
    CrossrefPubMedGoogle Scholar
  • 332 Ravikumara M, Hinsberger A, Spray CH. Role of methotrexate in the management of Crohn disease. J Pediatr Gastroenterol Nutr 2007; 44: 427-430
    CrossrefPubMedGoogle Scholar
  • 333 Regueiro M, Siemanowski B, Kip KE et al. Infliximab dose intensification in Crohn's disease. Inflamm Bowel Dis 2007; 13: 1093-1099
    CrossrefPubMedGoogle Scholar
  • 334 Sandborn WJ, Colombel JF, Schreiber S et al. Dosage adjustment during long-term adalimumab treatment for Crohn's disease: clinical efficacy and pharmacoeconomics. Inflamm Bowel Dis 2011; 17: 141-151
    CrossrefPubMedGoogle Scholar
  • 335 Baert F, Noman M, Vermeire S et al. Influence of immunogenicity on the long-term efficacy of infliximab in Crohn's disease. The New England journal of medicine 2003; 348: 601-608
    CrossrefPubMedGoogle Scholar
  • 336 Karmiris K, Paintaud G, Noman M et al. Influence of trough serum levels and immunogenicity on long-term outcome of adalimumab therapy in Crohn's disease. Gastroenterology 2009; 137: 1628-1640
    CrossrefPubMedGoogle Scholar
  • 337 Afif W, Loftus Jr EV, Faubion WA et al. Clinical utility of measuring infliximab and human anti-chimeric antibody concentrations in patients with inflammatory bowel disease. Am J Gastroenterol 2010; 105: 1133-1139
    CrossrefPubMedGoogle Scholar
  • 338 Ungar B, Chowers Y, Yavzori M et al. The temporal evolution of antidrug antibodies in patients with inflammatory bowel disease treated with infliximab. Gut 2013; DOI: 10.1136/gutjnl-2013-305259.
    PubMedGoogle Scholar
  • 339 Sandborn WJ, Rutgeerts P, Enns R et al. Adalimumab induction therapy for Crohn disease previously treated with infliximab: a randomized trial. Ann Intern Med 2007; 146: 829-838
    CrossrefPubMedGoogle Scholar
  • 340 Sandborn WJ, Abreu MT, D'Haens G et al. Certolizumab pegol in patients with moderate to severe Crohn's disease and secondary failure to infliximab. Clin Gastroenterol Hepatol 2010; 8: 688-695 e682
    CrossrefPubMedGoogle Scholar
  • 341 Allez M, Vermeire S, Mozziconacci N et al. The efficacy and safety of a third anti-TNF monoclonal antibody in Crohn's disease after failure of two other anti-TNF antibodies. Aliment Pharmacol Ther 2010; 31: 92-101
    CrossrefPubMedGoogle Scholar
  • 342 Navarro FA, Hanauer SB, Kirschner BS. Effect of long-term low-dose prednisone on height velocity and disease activity in pediatric and adolescent patients with Crohn disease. J Pediatr Gastroenterol Nutr 2007; 45: 312-318
    CrossrefPubMedGoogle Scholar
  • 343 Hyams J, Crandall W, Kugathasan S et al. Induction and maintenance infliximab therapy for the treatment of moderate-to-severe Crohn's disease in children. Gastroenterology 2007; 132: 863-873 ; quiz 1165-1166
    CrossrefPubMedGoogle Scholar
  • 344 Newby EA, Sawczenko A, Thomas AG et al. Interventions for growth failure in childhood Crohn's disease. Cochrane Database Syst Rev 2005; DOI: 10.1002/14651858.CD003873.pub2.
    PubMedGoogle Scholar
  • 345 Heuschkel RB, Menache CC, Megerian JT et al. Enteral nutrition and corticosteroids in the treatment of acute Crohn's disease in children. J Pediatr Gastroenterol Nutr 2000; 31: 8-15
    CrossrefPubMedGoogle Scholar
  • 346 Afzal NA, Davies S, Paintin M et al. Colonic Crohn's disease in children does not respond well to treatment with enteral nutrition if the ileum is not involved. Dig Dis Sci 2005; 50: 1471-1475
    CrossrefPubMedGoogle Scholar
  • 347 Escher JC. Budesonide versus prednisolone for the treatment of active Crohn's disease in children: a randomized, double-blind, controlled, multicentre trial. Eur J Gastroenterol Hepatol 2004; 16: 47-54
    CrossrefPubMedGoogle Scholar
  • 348 Levine A, Weizman Z, Broide E et al. A comparison of budesonide and prednisone for the treatment of active pediatric Crohn disease. J Pediatr Gastroenterol Nutr 2003; 36: 248-252
    CrossrefPubMedGoogle Scholar
  • 349 Henriksen M, Jahnsen J, Lygren I et al. Clinical course in Crohn's disease: results of a five-year population-based follow-up study (the IBSEN study). Scand J Gastroenterol 2007; 42: 602-610
    CrossrefPubMedGoogle Scholar
  • 350 Solberg IC, Vatn MH, Hoie O et al. Clinical course in Crohn's disease: results of a Norwegian population-based ten-year follow-up study. Clin Gastroenterol Hepatol 2007; 5: 1430-1438
    CrossrefPubMedGoogle Scholar
  • 351 Peyrin-Biroulet L, Loftus Jr EV, Colombel JF et al. The natural history of adult Crohn's disease in population-based cohorts. Am J Gastroenterol 2011; 105: 289-297
    PubMedGoogle Scholar
  • 352 Wilson B, Lonnfors S, Hommes DW et al. A European Crohn's and ulcerative colitis patient life IMPACT survey. JCC 2012; 6 (Suppl. 01) S171
    PubMedGoogle Scholar
  • 353 Bokemeyer BKA, Klugmann T, Franke G et al. Predictive factors for a mild course of Crohn's disease. Journal of Crohn's and Colitis 2009; 3: S82-S83
    PubMedGoogle Scholar
  • 354 Hauser W, Janke KH, Klump B et al. Anxiety and depression in patients with inflammatory bowel disease: comparisons with chronic liver disease patients and the general population. Inflamm Bowel Dis 2011; 17: 621-632
    CrossrefPubMedGoogle Scholar
  • 355 Peyrin-Biroulet L, Ferrante M, Magro F et al. Results from the 2nd Scientific Workshop of the ECCO. I: Impact of mucosal healing on the course of inflammatory bowel disease. Journal of Crohn's & colitis 2011; 5: 477-483
    PubMedGoogle Scholar
  • 356 D'Haens G, Sandborn WJ, Feagan BG et al. A review of activity indices and efficacy end points for clinical trials of medical therapy in adults with ulcerative colitis. Gastroenterology 2007; 132: 763-786
    CrossrefPubMedGoogle Scholar
  • 357 Takagi S, Utsunomiya K, Kuriyama S et al. Effectiveness of an "half elemental diet" as maintenance therapy for Crohn's disease: A randomized-controlled trial. Aliment Pharmacol Ther 2006; 24: 1333-1340
    CrossrefPubMedGoogle Scholar
  • 358 Wilschanski M, Sherman P, Pencharz P et al. Supplementary enteral nutrition maintains remission in paediatric Crohn's disease. Gut 1996; 38: 543-548
    CrossrefPubMedGoogle Scholar
  • 359 Mahid SS, Minor KS, Stromberg AJ et al. Active and passive smoking in childhood is related to the development of inflammatory bowel disease. Inflamm Bowel Dis 2007; 13: 431-438
    CrossrefPubMedGoogle Scholar
  • 360 Mahid SS, Minor KS, Soto RE et al. Smoking and inflammatory bowel disease: a meta-analysis. Mayo Clinic proceedings 2006; 81: 1462-1471
    CrossrefPubMedGoogle Scholar
  • 361 Timmer A, Sutherland LR, Martin F. Oral contraceptive use and smoking are risk factors for relapse in Crohn's disease. The Canadian Mesalamine for Remission of Crohn's Disease Study Group. Gastroenterology 1998; 114: 1143-1150
    CrossrefPubMedGoogle Scholar
  • 362 Kane SV, Flicker M, Katz-Nelson F. Tobacco use is associated with accelerated clinical recurrence of Crohn's disease after surgically induced remission. J Clin Gastroenterol 2005; 39: 32-35
    PubMedGoogle Scholar
  • 363 Johnson GJ, Cosnes J, Mansfield JC. Review article: smoking cessation as primary therapy to modify the course of Crohn's disease. Aliment Pharmacol Ther 2005; 21: 921-931
    CrossrefPubMedGoogle Scholar
  • 364 Cosnes J, Carbonnel F, Beaugerie L et al. Effects of cigarette smoking on the long-term course of Crohn's disease. Gastroenterology 1996; 110: 424-431
    CrossrefPubMedGoogle Scholar
  • 365 Breuer-Katschinski BD, Hollander N, Goebell H. Effect of cigarette smoking on the course of Crohn's disease. Eur J Gastroenterol Hepatol 1996; 8: 225-228
    CrossrefPubMedGoogle Scholar
  • 366 Steinhart AH, Ewe K, Griffiths AM et al. Corticosteroids for maintenance of remission in Crohn's disease. Cochrane Database Syst Rev 2003; DOI DOI: 10.1002/14651858.CD000301 [doi]. CD000301
    PubMedGoogle Scholar
  • 367 Smith RC, Rhodes J, Heatley RV et al. Low dose steroids and clinical relapse in Crohn's disease: a controlled trial. Gut 1978; 19: 606-610
    CrossrefPubMedGoogle Scholar
  • 368 Benchimol EI, Seow CH, Otley AR et al. Budesonide for maintenance of remission in Crohn's disease. Cochrane Database Syst Rev 2009; DOI: CD002913
    PubMedGoogle Scholar
  • 369 Prefontaine E, Sutherland LR, Macdonald JK et al. Azathioprine or 6-mercaptopurine for maintenance of remission in Crohn's disease. Cochrane Database Syst Rev 2009; DOI: CD000067
    PubMedGoogle Scholar
  • 370 Lemann M, Mary JY, Colombel JF et al. A randomized, double-blind, controlled withdrawal trial in Crohn's disease patients in long-term remission on azathioprine. Gastroenterology 2005; 128: 1812-1818
    CrossrefPubMedGoogle Scholar
  • 371 O'Donoghue DP, Dawson AM, Powell-Tuck J et al. Double-blind withdrawal trial of azathioprine as maintenance treatment for Crohn's disease. Lancet 1978; 2: 955-957
    PubMedGoogle Scholar
  • 372 Kamm MA. Review article: chronic active disease and maintaining remission in Crohn's disease. Aliment Pharmacol Ther 2004; 20 (Suppl. 04) 102-105
    PubMedGoogle Scholar
  • 373 Ludwig D, Stange EF. Efficacy of azathioprine in the treatment of chronic active Crohn's disease: prospective one-year follow-up study. German Imurek Study Group. Z Gastroenterol 1999; 37: 1085-1091
    PubMedGoogle Scholar
  • 374 Patel V, Macdonald JK, McDonald JW et al. Methotrexate for maintenance of remission in Crohn's disease. Cochrane Database Syst Rev 2009; DOI: CD006884
    PubMedGoogle Scholar
  • 375 Feagan BG, Fedorak RN, Irvine EJ et al. A comparison of methotrexate with placebo for the maintenance of remission in Crohn's disease. North American Crohn's Study Group Investigators. The New England journal of medicine 2000; 342: 1627-1632
    CrossrefPubMedGoogle Scholar
  • 376 Mate-Jimenez J, Hermida C, Cantero-Perona J et al. 6-mercaptopurine or methotrexate added to prednisone induces and maintains remission in steroid-dependent inflammatory bowel disease. Eur J Gastroenterol Hepatol 2000; 12: 1227-1233
    CrossrefPubMedGoogle Scholar
  • 377 Oren R, Moshkowitz M, Odes S et al. Methotrexate in chronic active Crohn's disease: a double-blind, randomized, Israeli multicenter trial. Am J Gastroenterol 1997; 92: 2203-2209
    PubMedGoogle Scholar
  • 378 Peyrin-Biroulet L, Deltenre P, de Suray N et al. Efficacy and safety of tumor necrosis factor antagonists in Crohn's disease: meta-analysis of placebo-controlled trials. Clin Gastroenterol Hepatol 2008; 6: 644-653
    CrossrefPubMedGoogle Scholar
  • 379 Behm BW, Bickston SJ. Tumor necrosis factor-alpha antibody for maintenance of remission in Crohn's disease. Cochrane Database Syst Rev 2008; DOI: CD006893
    PubMedGoogle Scholar
  • 380 Ford AC, Sandborn WJ, Khan KJ et al. Efficacy of biological therapies in inflammatory bowel disease: systematic review and meta-analysis. Am J Gastroenterol 2011; 106: 644-659 , quiz 660
    CrossrefPubMedGoogle Scholar
  • 381 Bokemeyer B, Hardt J, Huppe D et al. Clinical status, psychosocial impairments, medical treatment and health care costs for patients with inflammatory bowel disease (IBD) in Germany: An online IBD registry. Journal of Crohn's & colitis 2013; 7: 355-368
    PubMedGoogle Scholar
  • 382 Akobeng AK, Gardener E. Oral 5-aminosalicylic acid for maintenance of medically-induced remission in Crohn's Disease. Cochrane Database Syst Rev 2005; DOI: 10.1002/14651858.CD003715.pub2 [doi]. CD003715
    PubMedGoogle Scholar
  • 383 Steinhart AH, Forbes A, Mills EC et al. Systematic review: the potential influence of mesalazine formulation on maintenance of remission in Crohn's disease. Aliment Pharmacol Ther 2007; 25: 1389-1399
    CrossrefPubMedGoogle Scholar
  • 384 Verma S, Kirkwood B, Brown S et al. Oral nutritional supplementation is effective in the maintenance of remission in Crohn's disease. Dig Liver Dis 2000; 32: 769-774
    CrossrefPubMedGoogle Scholar
  • 385 Punati J, Markowitz J, Lerer T et al. Effect of early immunomodulator use in moderate to severe pediatric Crohn disease. Inflamm Bowel Dis 2008; 14: 949-954
    CrossrefPubMedGoogle Scholar
  • 386 Ramadas AV, Gunesh S, Thomas GA et al. Natural history of Crohn's disease in a population-based cohort from Cardiff (1986–2003): a study of changes in medical treatment and surgical resection rates. Gut 2010; 59: 1200-1206
    CrossrefPubMedGoogle Scholar
  • 387 D'Haens G, Baert F, van Assche G et al. Early combined immunosuppression or conventional management in patients with newly diagnosed Crohn's disease: an open randomised trial. Lancet 2008; 371: 660-667
    CrossrefPubMedGoogle Scholar
  • 388 Ordas I, Feagan BG, Sandborn WJ. Early use of immunosuppressives or TNF antagonists for the treatment of Crohn's disease: time for a change. Gut 2011; 60: 1754-1763
    CrossrefPubMedGoogle Scholar
  • 389 Rogler G. Top-down or step-up treatment in Crohn's disease?. Dig Dis 2013; 31: 83-90
    CrossrefPubMedGoogle Scholar
  • 390 Zallot C, Peyrin-Biroulet L. Clinical risk factors for complicated disease: how reliable are they?. Dig Dis 2012; 30 (Suppl. 03) 67-72
    CrossrefPubMedGoogle Scholar
  • 391 Thia KT, Sandborn WJ, Harmsen WS et al. Risk factors associated with progression to intestinal complications of Crohn's disease in a population-based cohort. Gastroenterology 2010; 139: 1147-1155
    CrossrefPubMedGoogle Scholar
  • 392 Allez M, Lemann M, Bonnet J et al. Long term outcome of patients with active Crohn's disease exhibiting extensive and deep ulcerations at colonoscopy. Am J Gastroenterol 2002; 97: 947-953
    PubMedGoogle Scholar
  • 393 Wenger S, Nikolaus S, Howaldt S et al. Predictors for subsequent need for immunosuppressive therapy in early Crohn's disease. Journal of Crohn's & colitis 2012; 6: 21-28
    PubMedGoogle Scholar
  • 394 Cottone M, Kohn A, Daperno M et al. Advanced age is an independent risk factor for severe infections and mortality in patients given anti-tumor necrosis factor therapy for inflammatory bowel disease. Clin Gastroenterol Hepatol 2011; 9: 30-35
    CrossrefPubMedGoogle Scholar
  • 395 Naganuma M, Kunisaki R, Yoshimura N et al. A prospective analysis of the incidence of and risk factors for opportunistic infections in patients with inflammatory bowel disease. J Gastroenterol 2013; 48: 595-600
    CrossrefPubMedGoogle Scholar
  • 396 Prenzler A, Bokemeyer B, von der Schulenburg JM et al. Health care costs and their predictors of inflammatory bowel diseases in Germany. Eur J Health Econ 2011; 12: 273-283
    CrossrefPubMedGoogle Scholar
  • 397 Dretzke J, Edlin R, Round J et al. A systematic review and economic evaluation of the use of tumour necrosis factor-alpha (TNF-alpha) inhibitors, adalimumab and infliximab, for Crohn's disease. Health Technol Assess 2011; 15: 1-244
    PubMedGoogle Scholar
  • 398 D'Haens GR, Panaccione R, Higgins PD et al. The London Position Statement of the World Congress of Gastroenterology on Biological Therapy for IBD with the European Crohn's and Colitis Organization: when to start, when to stop, which drug to choose, and how to predict response?. Am J Gastroenterol 2011; 106: 199-212 ; quiz 213
    CrossrefPubMedGoogle Scholar
  • 399 Lemann M, Mary JY, Duclos B et al. Infliximab plus azathioprine for steroid-dependent Crohn's disease patients: a randomized placebo-controlled trial. Gastroenterology 2006; 130: 1054-1061
    CrossrefPubMedGoogle Scholar
  • 400 Schroder O, Blumenstein I, Stein J. Combining infliximab with methotrexate for the induction and maintenance of remission in refractory Crohn's disease: a controlled pilot study. Eur J Gastroenterol Hepatol 2006; 18: 11-16
    CrossrefPubMedGoogle Scholar
  • 401 Rutgeerts P, D'Haens G, Targan S et al. Efficacy and safety of retreatment with anti-tumor necrosis factor antibody (infliximab) to maintain remission in Crohn's disease. Gastroenterology 1999; 117: 761-769
    CrossrefPubMedGoogle Scholar
  • 402 Johnson FR, Ozdemir S, Mansfield C et al. Crohn's disease patients' risk-benefit preferences: serious adverse event risks versus treatment efficacy. Gastroenterology 2007; 133: 769-779
    CrossrefPubMedGoogle Scholar
  • 403 Hindorf U, Johansson M, Eriksson A et al. Mercaptopurine treatment should be considered in azathioprine intolerant patients with inflammatory bowel disease. Aliment Pharmacol Ther 2009; 29: 654-661
    CrossrefPubMedGoogle Scholar
  • 404 Bokemeyer B, Teml A, Roggel C et al. Adherence to thiopurine treatment in out-patients with Crohn's disease. Aliment Pharmacol Ther 2007; 26: 217-225
    CrossrefPubMedGoogle Scholar
  • 405 Reinshagen M, Schutz E, Armstrong VW et al. 6-thioguanine nucleotide-adapted azathioprine therapy does not lead to higher remission rates than standard therapy in chronic active crohn disease: results from a randomized, controlled, open trial. Clinical chemistry 2007; 53: 1306-1314
    CrossrefPubMedGoogle Scholar
  • 406 Van Assche G, Magdelaine-Beuzelin C, D'Haens G et al. Withdrawal of immunosuppression in Crohn's disease treated with scheduled infliximab maintenance: a randomized trial. Gastroenterology 2008; 134: 1861-1868
    CrossrefPubMedGoogle Scholar
  • 407 Feagan BG, McDonald JW, Panaccione R et al. Methotrexate in Combination With Infliximab Is No More Effective Than Infliximab Alone in Patients With Crohn's Disease. Gastroenterology 2013; DOI: 10.1053/j.gastro.2013.11.024.
    PubMedGoogle Scholar
  • 408 Vilien M, Dahlerup JF, Munck LK et al. Randomized controlled azathioprine withdrawal after more than two years treatment in Crohn's disease: increased relapse rate the following year. Aliment Pharmacol Ther 2004; 19: 1147-1152
    CrossrefPubMedGoogle Scholar
  • 409 Treton X, Bouhnik Y, Mary JY et al. Azathioprine withdrawal in patients with Crohn's disease maintained on prolonged remission: a high risk of relapse. Clin Gastroenterol Hepatol 2009; 7: 80-85
    CrossrefPubMedGoogle Scholar
  • 410 Kandiel A, Fraser AG, Korelitz BI et al. Increased risk of lymphoma among inflammatory bowel disease patients treated with azathioprine and 6-mercaptopurine. Gut 2005; 54: 1121-1125
    CrossrefPubMedGoogle Scholar
  • 411 Te HS, Schiano TD, Kuan SF et al. Hepatic effects of long-term methotrexate use in the treatment of inflammatory bowel disease. Am J Gastroenterol 2000; 95: 3150-3156
    CrossrefPubMedGoogle Scholar
  • 412 Kennedy ED, To T, Steinhart AH et al. Do patients consider postoperative maintenance therapy for Crohn's disease worthwhile?. Inflamm Bowel Dis 2008; 14: 224-235
    CrossrefPubMedGoogle Scholar
  • 413 Caprilli R, Taddei G, Viscido A. In favour of prophylactic treatment for post-operative recurrence in Crohn's disease. Ital J Gastroenterol Hepatol 1998; 30: 219-225
    PubMedGoogle Scholar
  • 414 Breslin NP, Sutherland LR. The case against routine post-operative therapy for prevention of recurrence in Crohn's disease. Ital J Gastroenterol Hepatol 1998; 30: 226-230
    PubMedGoogle Scholar
  • 415 Rutgeerts P, Geboes K, Vantrappen G et al. Natural history of recurrent Crohn's disease at the ileocolonic anastomosis after curative surgery. Gut 1984; 25: 665-672
    CrossrefPubMedGoogle Scholar
  • 416 Swoger JM, Regueiro M. Preventive therapy in postoperative Crohn's disease. Curr Opin Gastroenterol 2010; 26: 337-343
    CrossrefPubMedGoogle Scholar
  • 417 Ng SC, Kamm MA. Management of postoperative Crohn's disease. Am J Gastroenterol 2008; 103: 1029-1035
    CrossrefPubMedGoogle Scholar
  • 418 Froehlich F, Juillerat P, Pittet V et al. Maintenance of surgically induced remission of Crohn's disease. Digestion 2007; 76: 130-135
    CrossrefPubMedGoogle Scholar
  • 419 Sutherland LR, Steinhart AH. Mesalazine as a maintenance treatment in Crohn's disease. Gut 1998; 42: 143-144
    PubMedGoogle Scholar
  • 420 Akobeng AK. Review article: the evidence base for interventions used to maintain remission in Crohn's disease. Aliment Pharmacol Ther 2008; 27: 11-18
    PubMedGoogle Scholar
  • 421 Hanauer SB, Korelitz BI, Rutgeerts P et al. Postoperative maintenance of Crohn's disease remission with 6-mercaptopurine, mesalamine, or placebo: a 2-year trial. Gastroenterology 2004; 127: 723-729
    CrossrefPubMedGoogle Scholar
  • 422 Ardizzone S, Maconi G, Sampietro GM et al. Azathioprine and mesalamine for prevention of relapse after conservative surgery for Crohn's disease. Gastroenterology 2004; 127: 730-740
    CrossrefPubMedGoogle Scholar
  • 423 Ananthakrishnan AN, McGinley EL, Binion DG. Does it matter where you are hospitalized for inflammatory bowel disease? A nationwide analysis of hospital volume. Am J Gastroenterol 2008; 103: 2789-2798
    CrossrefPubMedGoogle Scholar
  • 424 Eshuis EJ, Slors JF, Stokkers PC et al. Long-term outcomes following laparoscopically assisted versus open ileocolic resection for Crohn's disease. Br J Surg 2010; 97: 563-568
    CrossrefPubMedGoogle Scholar
  • 425 Lowney JK DD, Birnbaum EH, Kodner IJ et al. Is there any difference in recurrence rates in laparoscopic ileocolic resection for Crohn's disease compared with conventional surgery? A long-term, follow-up study. Dis Colon Rectum 2006; 49: 58-63
    CrossrefPubMedGoogle Scholar
  • 426 Graadal O, Nygaard K. Crohn disease. Long-term effects of surgical treatment. Tidsskr Nor Laegeforen 1994; 114: 1603-1605
    PubMedGoogle Scholar
  • 427 Nordgren SR, Fasth SB, Oresland TO et al. Long-term follow-up in Crohn's disease. Mortality, morbidity, and functional status. Scand J Gastroenterol 1994; 29: 1122-1128
    CrossrefPubMedGoogle Scholar
  • 428 Weston LA, Roberts PL, Schoetz Jr DJ et al. Ileocolic resection for acute presentation of Crohn's disease of the ileum. Dis Colon Rectum 1996; 39: 841-846
    CrossrefPubMedGoogle Scholar
  • 429 Kim NK, Senagore AJ, Luchtefeld MA et al. Long-term outcome after ileocecal resection for Crohn's disease. Am Surg 1997; 63: 627-633
    PubMedGoogle Scholar
  • 430 Borley NR, Mortensen NJ, Chaudry MA et al. Recurrence after abdominal surgery for Crohn's disease: relationship to disease site and surgical procedure. Dis Colon Rectum 2002; 45: 377-383
    CrossrefPubMedGoogle Scholar
  • 431 Unkart JT, Anderson L, Li E et al. Risk factors for surgical recurrence after ileocolic resection of Crohn's disease. Dis Colon Rectum 2008; 51: 1211-1216
    CrossrefPubMedGoogle Scholar
  • 432 Eshuis EJ, Bemelman WA, van Bodegraven AA et al. Laparoscopic ileocolic resection versus infliximab treatment of distal ileitis in Crohn's disease: a randomized multicenter trial (LIR!C-trial). BMC surgery 2008; 8: 15
    CrossrefPubMedGoogle Scholar
  • 433 Tillinger W, Mittermaier C, Lochs H et al. Health-related quality of life in patients with Crohn's disease: influence of surgical operation – a prospective trial. Dig Dis Sci 1999; 44: 932-938
    CrossrefPubMedGoogle Scholar
  • 434 Iesalnieks I, Kilger A, Glass H et al. Perforating Crohn's ileitis: delay of surgery is associated with inferior postoperative outcome. Inflamm Bowel Dis 2010; 16: 2125-2130
    CrossrefPubMedGoogle Scholar
  • 435 Aratari A, Papi C, Leandro G et al. Early versus late surgery for ileo-caecal Crohn's disease. Aliment Pharmacol Ther 2007; 26: 1303-1312
    CrossrefPubMedGoogle Scholar
  • 436 Pacilli M, Eaton S, Fell JM et al. Surgery in children with Crohn disease refractory to medical therapy. J Pediatr Gastroenterol Nutr 2011; 52: 286-290
    CrossrefPubMedGoogle Scholar
  • 437 Basseri RJ, Basseri B, Vassilaki ME et al. Colorectal cancer screening and surveillance in Crohn's colitis. Journal of Crohn's & colitis 2012; 6: 824-829
    PubMedGoogle Scholar
  • 438 Steinberg DM, Cooke WT, Alexander-Williams J. Free perforation in Crohn's disease. Gut 1973; 14: 187-190
    CrossrefPubMedGoogle Scholar
  • 439 Nagler SM, Poticha SM. Intraabdominal abscess in regional enteritis. American journal of surgery 1979; 137: 350-354
    CrossrefPubMedGoogle Scholar
  • 440 Bafford AC, Coakley B, Powers S et al. The clinical impact of preoperative percutaneous drainage of abdominopelvic abscesses in patients with Crohn's disease. Int J Colorectal Dis 2012; 27: 953-958
    CrossrefPubMedGoogle Scholar
  • 441 Bermejo F, Garrido E, Chaparro M et al. Efficacy of different therapeutic options for spontaneous abdominal abscesses in Crohn's disease: are antibiotics enough?. Inflamm Bowel Dis 2012; 18: 1509-1514
    CrossrefPubMedGoogle Scholar
  • 442 da Luz Moreira A, Stocchi L, Tan E et al. Outcomes of Crohn's disease presenting with abdominopelvic abscess. Dis Colon Rectum 2009; 52: 906-912
    CrossrefPubMedGoogle Scholar
  • 443 Gutierrez A, Lee H, Sands BE. Outcome of surgical versus percutaneous drainage of abdominal and pelvic abscesses in Crohn's disease. Am J Gastroenterol 2006; 101: 2283-2289
    CrossrefPubMedGoogle Scholar
  • 444 Xie Y, Zhu W, Li N et al. The outcome of initial percutaneous drainage versus surgical drainage for intra-abdominal abscesses in Crohn's disease. Int J Colorectal Dis 2012; 27: 199-206
    CrossrefPubMedGoogle Scholar
  • 445 Keighley MR, Eastwood D, Ambrose NS et al. Incidence and microbiology of abdominal and pelvic abscess in Crohn's disease. Gastroenterology 1982; 83: 1271-1275
    PubMedGoogle Scholar
  • 446 Stallmach A, Hagel S, Bruns T et al. Kalkulierte Antibiotikatherapie bei intraabdominellen Infektionen – Fallbeispiele und evidenzbasierte Therapieempfehlungen. Z Gastroenterol 2013; 51: 1069-1081
    Article in Thieme ConnectPubMedGoogle Scholar
  • 447 Garcia JC, Persky SE, Bonis PA et al. Abscesses in Crohn's disease: outcome of medical versus surgical treatment. J Clin Gastroenterol 2001; 32: 409-412
    CrossrefPubMedGoogle Scholar
  • 448 Louis E, Collard A, Oger AF et al. Behaviour of Crohn's disease according to the Vienna classification: changing pattern over the course of the disease. Gut 2001; 49: 777-782
    CrossrefPubMedGoogle Scholar
  • 449 Schirin-Sokhan RWR, Tischendorf S, Wasmuth HE et al. Assessment of inflammatory and fibrotic stenoses in patients with Crohn's disease using contrast-enhanced ultrasound and computerized algorithm: a pilot study. Digestion 2011; 83: 263-268
    CrossrefPubMedGoogle Scholar
  • 450 Quaia EDPL, Stocca T, Cabibbo B et al. The value of small bowel wall contrast enhancement after sulfur hexafluoride-filled microbubble injection to differentiate inflammatory from fibrotic strictures in patients with Crohn's disease. Ultrasound Med Biol 2012; 38: 1324-1332
    CrossrefPubMedGoogle Scholar
  • 451 Jensen MD, Kjeldsen J, Rafaelsen SR et al. Diagnostic accuracies of MR enterography and CT enterography in symptomatic Crohn's disease. Scand J Gastroenterol 2011; 46: 1449-1457
    CrossrefPubMedGoogle Scholar
  • 452 Malgras B, Soyer P, Boudiaf M et al. Accuracy of imaging for predicting operative approach in Crohn's disease. Br J Surg 2012; 99: 1011-1020
    CrossrefPubMedGoogle Scholar
  • 453 Rieder F, Zimmermann EM, Remzi FH et al. Crohn's disease complicated by strictures: a systematic review. Gut 2013; 62: 1072-1084
    CrossrefPubMedGoogle Scholar
  • 454 Hassan C, Zullo A, De Francesco V et al. Systematic review: Endoscopic dilatation in Crohn's disease. Aliment Pharmacol Ther 2007; 26: 1457-1464
    CrossrefPubMedGoogle Scholar
  • 455 Scimeca D, Mocciaro F, Cottone M et al. Efficacy and safety of endoscopic balloon dilation of symptomatic intestinal Crohn's disease strictures. Dig Liver Dis 2011; 43: 121-125
    CrossrefPubMedGoogle Scholar
  • 456 Gustavsson A, Magnuson A, Blomberg B et al. Endoscopic dilation is an efficacious and safe treatment of intestinal strictures in Crohn's disease. Aliment Pharmacol Ther 2012; 36: 151-158
    CrossrefPubMedGoogle Scholar
  • 457 Mueller T, Rieder B, Bechtner G et al. The response of Crohn's strictures to endoscopic balloon dilation. Aliment Pharmacol Ther 2010; 31: 634-639
    CrossrefPubMedGoogle Scholar
  • 458 Wibmer AG, Kroesen AJ, Grone J et al. Comparison of strictureplasty and endoscopic balloon dilatation for stricturing Crohn's disease – review of the literature. Int J Colorectal Dis 2010; 25: 1149-1157
    CrossrefPubMedGoogle Scholar
  • 459 Campbell L, Ambe R, Weaver J et al. Comparison of conventional and nonconventional strictureplasties in Crohn's disease: a systematic review and meta-analysis. Dis Colon Rectum 2012; 55: 714-726
    CrossrefPubMedGoogle Scholar
  • 460 Reese GE, Purkayastha S, Tilney HS et al. Strictureplasty vs resection in small bowel Crohn's disease: an evaluation of short-term outcomes and recurrence. Colorectal Dis 2007; 9: 686-694
    CrossrefPubMedGoogle Scholar
  • 461 Choy PY, Bissett IP, Docherty JG et al. Stapled versus handsewn methods for ileocolic anastomoses. Cochrane Database Syst Rev 2011; DOI: 10.1002/14651858.CD004320.pub3.
    PubMedGoogle Scholar
  • 462 McLeod RS, Wolff BG, Ross S et al. Recurrence of Crohn's disease after ileocolic resection is not affected by anastomotic type: results of a multicenter, randomized, controlled trial. Dis Colon Rectum 2009; 52: 919-927
    CrossrefPubMedGoogle Scholar
  • 463 Tilney HS, Constantinides VA, Heriot AG et al. Comparison of laparoscopic and open ileocecal resection for Crohn's disease: a metaanalysis. Surg Endosc 2006; 20: 1036-1044
    CrossrefPubMedGoogle Scholar
  • 464 Tan JJ, Tjandra JJ. Laparoscopic surgery for Crohn's disease: a meta-analysis. Dis Colon Rectum 2007; 50: 576-585
    CrossrefPubMedGoogle Scholar
  • 465 Eshuis EJ, Polle SW, Slors JF et al. Long-term surgical recurrence, morbidity, quality of life, and body image of laparoscopic-assisted vs. open ileocolic resection for Crohn's disease: a comparative study. Dis Colon Rectum 2008; 51: 858-867
    CrossrefPubMedGoogle Scholar
  • 466 Pinto RA, Shawki S, Narita K et al. Laparoscopy for recurrent Crohn's disease: how do the results compare with the results for primary Crohn's disease?. Colorectal Dis 2011; 13: 302-307
    CrossrefPubMedGoogle Scholar
  • 467 Chaudhary B, Glancy D, Dixon AR. Laparoscopic surgery for recurrent ileocolic Crohn's disease is as safe and effective as primary resection. Colorectal Dis 2011; 13: 1413-1416
    CrossrefPubMedGoogle Scholar
  • 468 Tekkis PP, Purkayastha S, Lanitis S et al. A comparison of segmental vs subtotal/total colectomy for colonic Crohn's disease: a meta-analysis. Colorectal Dis 2006; 8: 82-90
    CrossrefPubMedGoogle Scholar
  • 469 Broering DC, Eisenberger CF, Koch A et al. Strictureplasty for large bowel stenosis in Crohn's disease: quality of life after surgical therapy. Int J Colorectal Dis 2001; 16: 81-87
    CrossrefPubMedGoogle Scholar
  • 470 Reese GE, Lovegrove RE, Tilney HS et al. The effect of Crohn's disease on outcomes after restorative proctocolectomy. Dis Colon Rectum 2007; 50: 239-250
    CrossrefPubMedGoogle Scholar
  • 471 Yang SS, Yu CS, Yoon YS et al. Risk factors for complications after bowel surgery in Korean patients with Crohn's disease. Journal of the Korean Surgical Society 2012; 83: 141-148
    CrossrefPubMedGoogle Scholar
  • 472 Appau KA, Fazio VW, Shen B et al. Use of infliximab within 3 months of ileocolonic resection is associated with adverse postoperative outcomes in Crohn's patients. J Gastrointest Surg 2008; 12: 1738-1744
    CrossrefPubMedGoogle Scholar
  • 473 Myrelid P, Soderholm JD, Olaison G et al. Split stoma in resectional surgery of high-risk patients with ileocolonic Crohn's disease. Colorectal Dis 2012; 14: 188-193
    CrossrefPubMedGoogle Scholar
  • 474 Iesalnieks I, Dederichs F, Kilger A et al. Postoperative morbidity after bowel resections in patients with Crohn's disease: risk, management strategies, prevention. Z Gastroenterol 2012; 50: 595-600
    Article in Thieme ConnectPubMedGoogle Scholar
  • 475 Weimann A, Braga M, Harsanyi L et al. ESPEN Guidelines on Enteral Nutrition: Surgery including organ transplantation. Clinical nutrition (Edinburgh, Scotland) 2006; 25: 224-244
    CrossrefPubMedGoogle Scholar
  • 476 Subramanian V, Saxena S, Kang JY et al. Preoperative steroid use and risk of postoperative complications in patients with inflammatory bowel disease undergoing abdominal surgery. Am J Gastroenterol 2008; 103: 2373-2381
    CrossrefPubMedGoogle Scholar
  • 477 El-Hussuna A, Andersen J, Bisgaard T et al. Biologic treatment or immunomodulation is not associated with postoperative anastomotic complications in abdominal surgery for Crohn's disease. Scand J Gastroenterol 2012; 47: 662-668
    CrossrefPubMedGoogle Scholar
  • 478 Myrelid P, Olaison G, Sjodahl R et al. Thiopurine therapy is associated with postoperative intra-abdominal septic complications in abdominal surgery for Crohn's disease. Dis Colon Rectum 2009; 52: 1387-1394
    CrossrefPubMedGoogle Scholar
  • 479 Billioud V, Ford AC, Tedesco ED et al. Preoperative use of anti-TNF therapy and postoperative complications in inflammatory bowel diseases: a meta-analysis. Journal of Crohn's & colitis 2013; 7: 853-867
    PubMedGoogle Scholar
  • 480 Marchal L, D'Haens G, Van Assche G et al. The risk of post-operative complications associated with infliximab therapy for Crohn's disease: a controlled cohort study. Aliment Pharmacol Ther 2004; 19: 749-754
    CrossrefPubMedGoogle Scholar
  • 481 O'Donoghue DP, Hyland JM. Perianal Crohn's disease. Eur J Gastroenterol Hepatol 1997; 9: 235-236
    CrossrefPubMedGoogle Scholar
  • 482 Sangwan YP, Schoetz DJ Jr, Murray JJ et al. Perianal Crohn's disease. Results of local surgical treatment. Dis Colon Rectum 1996; 39: 529-535
    CrossrefPubMedGoogle Scholar
  • 483 Lichtenstein GR. Treatment of fistulizing Crohn's disease. Gastroenterology 2000; 119: 1132-1147
    CrossrefPubMedGoogle Scholar
  • 484 Solomon MJ. Fistulae and abscesses in symptomatic perianal Crohn's disease. Int J Colorectal Dis 1996; 11: 222-226
    CrossrefPubMedGoogle Scholar
  • 485 Mardini HE, Schwartz DA. Treatment of Perianal Fistula and Abscess: Crohn's and Non-Crohn's. Current treatment options in gastroenterology 2007; 10: 211-220
    CrossrefPubMedGoogle Scholar
  • 486 Steele SR, Kumar R, Feingold DL et al. Practice parameters for the management of perianal abscess and fistula-in-ano. Dis Colon Rectum 2011; 54: 1465-1474
    CrossrefPubMedGoogle Scholar
  • 487 Buchanan GN, Owen HA, Torkington J et al. Long-term outcome following loose-seton technique for external sphincter preservation in complex anal fistula. Br J Surg 2004; 91: 476-480
    CrossrefPubMedGoogle Scholar
  • 488 Bernstein LH, Frank MS, Brandt LJ et al. Healing of perineal Crohn's disease with metronidazole. Gastroenterology 1980; 79: 357-365
    PubMedGoogle Scholar
  • 489 Llera JL, Levy RC. Treatment of cutaneous abscess: a double-blind clinical study. Annals of emergency medicine 1985; 14: 15-19
    CrossrefPubMedGoogle Scholar
  • 490 Stewart MP, Laing MR, Krukowski ZH. Treatment of acute abscesses by incision, curettage and primary suture without antibiotics: a controlled clinical trial. Br J Surg 1985; 72: 66-67
    CrossrefPubMedGoogle Scholar
  • 491 Macfie J, Harvey J. The treatment of acute superficial abscesses: a prospective clinical trial. Br J Surg 1977; 64: 264-266
    CrossrefPubMedGoogle Scholar
  • 492 Present DH, Korelitz BI, Wisch N et al. Treatment of Crohn's disease with 6-mercaptopurine. A long-term, randomized, double-blind study. The New England journal of medicine 1980; 302: 981-987
    CrossrefPubMedGoogle Scholar
  • 493 Pearson DC, May GR, Fick GH et al. Azathioprine and 6-mercaptopurine in Crohn disease. A meta-analysis. Ann Intern Med 1995; 123: 132-142
    CrossrefPubMedGoogle Scholar
  • 494 Present DH, Rutgeerts P, Targan S et al. Infliximab for the treatment of fistulas in patients with Crohn's disease. The New England journal of medicine 1999; 340: 1398-1405
    CrossrefPubMedGoogle Scholar
  • 495 Sands BE, Blank MA, Patel K et al. Long-term treatment of rectovaginal fistulas in Crohn's disease: response to infliximab in the ACCENT II Study. Clin Gastroenterol Hepatol 2004; 2: 912-920
    CrossrefPubMedGoogle Scholar
  • 496 Kasparek MS, Glatzle J, Temeltcheva T et al. Long-term quality of life in patients with Crohn's disease and perianal fistulas: influence of fecal diversion. Dis Colon Rectum 2007; 50: 2067-2074
    CrossrefPubMedGoogle Scholar
  • 497 Singh B, George BD, Mortensen NJ. Surgical therapy of perianal Crohn's disease. Dig Liver Dis 2007; 39: 988-992
    CrossrefPubMedGoogle Scholar
  • 498 Yamamoto T, Allan RN, Keighley MR. Effect of fecal diversion alone on perianal Crohn's disease. World J Surg 2000; 24: 1258-1262 ; discussion 1262-1253
    CrossrefPubMedGoogle Scholar
  • 499 Galandiuk S, Kimberling J, Al-Mishlab TG et al. Perianal Crohn disease: predictors of need for permanent diversion. Ann Surg 2005; 241: 796-801
    CrossrefPubMedGoogle Scholar
  • 500 [Anonym]. American Gastroenterological Association medical position statement: perianal Crohn's disease. Gastroenterology 2003; 125: 1503-1507
    CrossrefPubMedGoogle Scholar
  • 501 Buhr HJ, Kroesen AJ, Herfarth C. Surgical therapy of recurrent Crohn disease. Chirurg 1995; 66: 764-773
    PubMedGoogle Scholar
  • 502 Sonnenberg A, Gavin MW. Timing of surgery for enterovesical fistula in Crohn's disease: decision analysis using a time-dependent compartment model. Inflamm Bowel Dis 2000; 6: 280-285
    PubMedGoogle Scholar
  • 503 Gasche C, Berstad A, Befrits R et al. Guidelines on the diagnosis and management of iron deficiency and anemia in inflammatory bowel diseases. Inflamm Bowel Dis 2007; 13: 1545-1553
    CrossrefPubMedGoogle Scholar
  • 504 Duerksen DR, Fallows G, Bernstein CN. Vitamin B12 malabsorption in patients with limited ileal resection. Nutrition 2006; 22: 1210-1213
    CrossrefPubMedGoogle Scholar
  • 505 Stein J, Hartmann F, Dignass AU. Diagnosis and management of iron deficiency anemia in patients with IBD. Nature reviews Gastroenterology & hepatology 2010; 7: 599-610
    PubMedGoogle Scholar
  • 506 Oustamanolakis P, Koutroubakis IE. Soluble transferrin receptor-ferritin index is the most efficient marker for the diagnosis of iron deficiency anemia in patients with IBD. Inflamm Bowel Dis 2011; 17: E158-E159
    CrossrefPubMedGoogle Scholar
  • 507 Skikne BS, Punnonen K, Caldron PH et al. Improved differential diagnosis of anemia of chronic disease and iron deficiency anemia: a prospective multicenter evaluation of soluble transferrin receptor and the sTfR/log ferritin index. Am J Hematol 2011; 86: 923-927
    CrossrefPubMedGoogle Scholar
  • 508 Wells CW, Lewis S, Barton JR et al. Effects of changes in hemoglobin level on quality of life and cognitive function in inflammatory bowel disease patients. Inflamm Bowel Dis 2006; 12: 123-130
    CrossrefPubMedGoogle Scholar
  • 509 Lee TW, Kolber MR, Fedorak RN et al. Iron replacement therapy in inflammatory bowel disease patients with iron deficiency anemia: a systematic review and meta-analysis. Journal of Crohn's & colitis 2011; 6: 267-275
    PubMedGoogle Scholar
  • 510 Lindgren S, Wikman O, Befrits R et al. Intravenous iron sucrose is superior to oral iron sulphate for correcting anaemia and restoring iron stores in IBD patients: A randomized, controlled, evaluator-blind, multicentre study. Scand J Gastroenterol 2009; 44: 838-845
    CrossrefPubMedGoogle Scholar
  • 511 Schroder O, Mickisch O, Seidler U et al. Intravenous iron sucrose versus oral iron supplementation for the treatment of iron deficiency anemia in patients with inflammatory bowel disease--a randomized, controlled, open-label, multicenter study. Am J Gastroenterol 2005; 100: 2503-2509
    CrossrefPubMedGoogle Scholar
  • 512 Kulnigg S, Stoinov S, Simanenkov V et al. A novel intravenous iron formulation for treatment of anemia in inflammatory bowel disease: the ferric carboxymaltose (FERINJECT) randomized controlled trial. Am J Gastroenterol 2008; 103: 1182-1192
    CrossrefPubMedGoogle Scholar
  • 513 Ganzoni AM. Intravenous iron-dextran: therapeutic and experimental possibilities. Schweiz Med Wochenschr 1970; 100: 301-303
    PubMedGoogle Scholar
  • 514 Fresenius Medical Care Nephrologica Deutschland GmbH, Medice Arzneimittel Pütter GmbH & Co. KG, Pharmacosmos A/S et al. Verschärfte Empfehlungen bezüglich des Risikos schwerer Überempfindlichkeitsreaktionen auf Eisen-Präparate zur intravenösen Applikation. 2013 Im Internet: http://www.bfarm.de/SharedDocs/Risikoinformationen/Pharmakovigilanz/DE/RHB/2013/rhb-eisen-iv.pdf?__blob=publicationFile&v=2 Zugriff: 30.4.2013
    PubMedGoogle Scholar
  • 515 Hvas AM, Nexo E. Diagnosis and treatment of vitamin B12 deficiency – an update. Haematologica 2006; 91: 1506-1512
    PubMedGoogle Scholar
  • 516 Manganelli C, Turco S, Balestrazzi E. Ophthalmological aspects of IBD. European review for medical and pharmacological sciences 2009; 13 (Suppl. 01) 11-13
    PubMedGoogle Scholar
  • 517 Dougados M, van der Linden S, Juhlin R et al. The European Spondylarthropathy Study Group preliminary criteria for the classification of spondylarthropathy. Arthritis Rheum 1991; 34: 1218-1227
    CrossrefPubMedGoogle Scholar
  • 518 Orchard TR, Wordsworth BP, Jewell DP. Peripheral arthropathies in inflammatory bowel disease: their articular distribution and natural history. Gut 1998; 42: 387-391
    CrossrefPubMedGoogle Scholar
  • 519 Palm O, Moum B, Ongre A et al. Prevalence of ankylosing spondylitis and other spondyloarthropathies among patients with inflammatory bowel disease: a population study (the IBSEN study). The Journal of rheumatology 2002; 29: 511-515
    PubMedGoogle Scholar
  • 520 Palm O, Moum B, Jahnsen J et al. The prevalence and incidence of peripheral arthritis in patients with inflammatory bowel disease, a prospective population-based study (the IBSEN study). Rheumatology (Oxford) 2001; 40: 1256-1261
    CrossrefPubMedGoogle Scholar
  • 521 Sarzi-Puttini P, Ardizzone S, Manzionna G et al. Infliximab-induced lupus in Crohn's disease: a case report. Dig Liver Dis 2003; 35: 814-817
    CrossrefPubMedGoogle Scholar
  • 522 Dueckers G, Guellac N, Arbogast M et al. Evidence and consensus based GKJR guidelines for the treatment of juvenile idiopathic arthritis. Clin Immunol 2012; 142: 176-193
    CrossrefPubMedGoogle Scholar
  • 523 Dotson J, Crandall W, Bout-Tabaku S. Exploring the differential diagnosis of joint complaints in pediatric patients with inflammatory bowel disease. Curr Gastroenterol Rep 2011; 13: 271-278
    CrossrefPubMedGoogle Scholar
  • 524 Herfarth H, Obermeier F, Andus T et al. Improvement of arthritis and arthralgia after treatment with infliximab (Remicade) in a German prospective, open-label, multicenter trial in refractory Crohn's disease. Am J Gastroenterol 2002; 97: 2688-2690
    CrossrefPubMedGoogle Scholar
  • 525 Whittle SL, Richards BL, Husni E et al. Opioid therapy for treating rheumatoid arthritis pain. Cochrane Database Syst Rev 2011; DOI: 10.1002/14651858.CD003113.pub3: CD003113
    PubMedGoogle Scholar
  • 526 Takeuchi K, Smale S, Premchand P et al. Prevalence and mechanism of nonsteroidal anti-inflammatory drug-induced clinical relapse in patients with inflammatory bowel disease. Clin Gastroenterol Hepatol 2006; 4: 196-202
    CrossrefPubMedGoogle Scholar
  • 527 El MiedanyY, Youssef S, Ahmed I et al. The gastrointestinal safety and effect on disease activity of etoricoxib, a selective cox-2 inhibitor in inflammatory bowel diseases. Am J Gastroenterol 2006; 101: 311-317
    CrossrefPubMedGoogle Scholar
  • 528 Sandborn WJ, Stenson WF, Brynskov J et al. Safety of celecoxib in patients with ulcerative colitis in remission: a randomized, placebo-controlled, pilot study. Clin Gastroenterol Hepatol 2006; 4: 203-211
    CrossrefPubMedGoogle Scholar
  • 529 Jones G, Halbert J, Crotty M et al. The effect of treatment on radiological progression in rheumatoid arthritis: a systematic review of randomized placebo-controlled trials. Rheumatology (Oxford) 2003; 42: 6-13
    CrossrefPubMedGoogle Scholar
  • 530 Farhi D, Cosnes J, Zizi N et al. Significance of erythema nodosum and pyoderma gangrenosum in inflammatory bowel diseases: a cohort study of 2402 patients. Medicine (Baltimore) 2008; 87: 281-293
    CrossrefPubMedGoogle Scholar
  • 531 Harrison MJ, Dixon WG, Watson KD et al. Rates of new-onset psoriasis in patients with rheumatoid arthritis receiving anti-tumour necrosis factor alpha therapy: results from the British Society for Rheumatology Biologics Register. Annals of the rheumatic diseases 2009; 68: 209-215
    CrossrefPubMedGoogle Scholar
  • 532 Guerra I, Algaba A, Perez-Calle JL et al. Induction of psoriasis with anti-TNF agents in patients with inflammatory bowel disease: a report of 21 cases. Journal of Crohn's & colitis 2012; 6: 518-523
    PubMedGoogle Scholar
  • 533 Mert A, Kumbasar H, Ozaras R et al. Erythema nodosum: an evaluation of 100 cases. Clin Exp Rheumatol 2007; 25: 563-570
    PubMedGoogle Scholar
  • 534 Baumgart DC, Grittner U, Steingraber A et al. Frequency, phenotype, outcome, and therapeutic impact of skin reactions following initiation of adalimumab therapy: experience from a consecutive cohort of inflammatory bowel disease patients. Inflamm Bowel Dis 2011; 17: 2512-2520
    CrossrefPubMedGoogle Scholar
  • 535 Brooklyn TN, Dunnill MG, Shetty A et al. Infliximab for the treatment of pyoderma gangrenosum: a randomised, double blind, placebo controlled trial. Gut 2006; 55: 505-509
    CrossrefPubMedGoogle Scholar
  • 536 Campbell S, Cripps S, Jewell DP. Therapy Insight: pyoderma gangrenosum-old disease, new management. Nat Clin Pract Gastroenterol Hepatol 2005; 2: 587-594
    CrossrefPubMedGoogle Scholar
  • 537 Miller J, Yentzer BA, Clark A et al. Pyoderma gangrenosum: a review and update on new therapies. J Am Acad Dermatol 2010; 62: 646-654
    CrossrefPubMedGoogle Scholar
  • 538 Baranska-Rybak W, Kakol M, Naesstrom M et al. A retrospective study of 12 cases of pyoderma gangrenosum: why we should avoid surgical intervention and what therapy to apply. Am Surg 2011; 77: 1644-1649
    PubMedGoogle Scholar
  • 539 Dave M, Elmunzer BJ, Dwamena BA et al. Primary sclerosing cholangitis: meta-analysis of diagnostic performance of MR cholangiopancreatography. Radiology 2010; 256: 387-396
    CrossrefPubMedGoogle Scholar
  • 540 Weber C, Kuhlencordt R, Grotelueschen R et al. Magnetic resonance cholangiopancreatography in the diagnosis of primary sclerosing cholangitis. Endoscopy 2008; 40: 739-745
    Article in Thieme ConnectPubMedGoogle Scholar
  • 541 Miloh T, Arnon R, Shneider B et al. A retrospective single-center review of primary sclerosing cholangitis in children. Clin Gastroenterol Hepatol 2009; 7: 239-245
    CrossrefPubMedGoogle Scholar
  • 542 Lindor KD, Kowdley KV, Luketic VA et al. High-dose ursodeoxycholic acid for the treatment of primary sclerosing cholangitis. Hepatology 2009; 50: 808-814
    CrossrefPubMedGoogle Scholar
  • 543 Pardi DS, Loftus Jr EV. Kremers WK et al. Ursodeoxycholic acid as a chemopreventive agent in patients with ulcerative colitis and primary sclerosing cholangitis. Gastroenterology 2003; 124: 889-893
    CrossrefPubMedGoogle Scholar
  • 544 Lindstrom L, Boberg KM, Wikman O et al. High dose ursodeoxycholic acid in primary sclerosing cholangitis does not prevent colorectal neoplasia. Aliment Pharmacol Ther 2012; 35: 451-457
    CrossrefPubMedGoogle Scholar
  • 545 Aljiffry M, Renfrew PD, Walsh MJ et al. Analytical review of diagnosis and treatment strategies for dominant bile duct strictures in patients with primary sclerosing cholangitis. HPB: the official journal of the International Hepato Pancreato Biliary Association 2011; 13: 79-90
    CrossrefPubMedGoogle Scholar
  • 546 Mieli-Vergani G, Vergani D. Unique features of primary sclerosing cholangitis in children. Curr Opin Gastroenterol 2010; 26: 265-268
    CrossrefPubMedGoogle Scholar
  • 547 Klaus J, Armbrecht G, Steinkamp M et al. High prevalence of osteoporotic vertebral fractures in patients with Crohn's disease. Gut 2002; 51: 654-658
    CrossrefPubMedGoogle Scholar
  • 548 Vazquez MA, Lopez E, Montoya MJ et al. Vertebral fractures in patients with inflammatory bowel disease compared with a healthy population: a prospective case-control study. BMC gastroenterology 2012; 12: 47
    CrossrefPubMedGoogle Scholar
  • 549 DVO. DVO-Leitlinie 2009 zur Prophylaxe, Diagnostik und Therapie der Osteoporose bei Erwachsenen. Osteologie 2009; 18: 304-328
    PubMedGoogle Scholar
  • 550 Bundesministerium für Gesundheit. Bekanntmachung eines Beschlusses des Gemeinsamen Bundesausschusses über eine Änderung der Richtlinie Methoden vertragsärztliche Versorgung (MVV-RL): Osteodensitometrie bei Osteoporose – vom: 21.2.2013. BAnz AT; 2013
    PubMedGoogle Scholar
  • 551 Cravo M, Guerreiro CS, dos Santos PM et al. Risk factors for metabolic bone disease in Crohn's disease patients. Inflamm Bowel Dis 2010; 16: 2117-2124
    CrossrefPubMedGoogle Scholar
  • 552 Bechtold-Dalla Pozza S. Knochendichtemessungen beim wachsenden Skelett und die klinischen Konsequenzen. Zeitschrift fur Rheumatologie 2011; 70: 844-852
    CrossrefPubMedGoogle Scholar
  • 553 Sentongo TA, Semaeo EJ, Stettler N et al. Vitamin D status in children, adolescents, and young adults with Crohn disease. Am J Clin Nutr 2002; 76: 1077-1081
    PubMedGoogle Scholar
  • 554 Siffledeen JS, Siminoski K, Steinhart H et al. The frequency of vitamin D deficiency in adults with Crohn's disease. Can J Gastroenterol 2003; 17: 473-478
    PubMedGoogle Scholar
  • 555 Levin AD, Wadhera V, Leach ST et al. Vitamin D deficiency in children with inflammatory bowel disease. Dig Dis Sci 2011; 56: 830-836
    CrossrefPubMedGoogle Scholar
  • 556 Robinson RJ, Krzywicki T, Almond L et al. Effect of a low-impact exercise program on bone mineral density in Crohn's disease: a randomized controlled trial. Gastroenterology 1998; 115: 36-41
    CrossrefPubMedGoogle Scholar
  • 557 Holick MF, Binkley NC, Bischoff-Ferrari HA et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. The Journal of clinical endocrinology and metabolism 2011; 96: 1911-1930
    CrossrefPubMedGoogle Scholar
  • 558 Ross AC, Manson JE, Abrams SA et al. The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. The Journal of clinical endocrinology and metabolism 2011; 96: 53-58
    CrossrefPubMedGoogle Scholar
  • 559 Soo I, Siffledeen J, Siminoski K et al. Risedronate improves bone mineral density in Crohn's disease: a two year randomized controlled clinical trial. Journal of Crohn's & colitis 2012; 6: 777-786
    PubMedGoogle Scholar
  • 560 Worcester EM. Stones from bowel disease. Endocrinol Metab Clin North Am 2002; 31: 979-999
    CrossrefPubMedGoogle Scholar
  • 561 Lieske JC, Tremaine WJ, De Simone C et al. Diet, but not oral probiotics, effectively reduces urinary oxalate excretion and calcium oxalate supersaturation. Kidney Int 2010; 78: 1178-1185
    CrossrefPubMedGoogle Scholar
  • 562 Taylor EN, Stampfer MJ, Curhan GC. Dietary factors and the risk of incident kidney stones in men: new insights after 14 years of follow-up. J Am Soc Nephrol 2004; 15: 3225-3232
    CrossrefPubMedGoogle Scholar
  • 563 Grainge MJ, West J, Card TR. Venous thromboembolism during active disease and remission in inflammatory bowel disease: a cohort study. Lancet 2010; 375: 657-663
    CrossrefPubMedGoogle Scholar
  • 564 Kappelman MD, Horvath-Puho E, Sandler RS et al. Thromboembolic risk among Danish children and adults with inflammatory bowel diseases: a population-based nationwide study. Gut 2011; 60: 937-943
    CrossrefPubMedGoogle Scholar
  • 565 Hach-Wunderle V, Blättler W, Gerlach H et al. Diagnostik und Therapie der Venenthrombose und der Lungenembolie. 2010 Im Internet: http://www.awmf.org/uploads/tx_szleitlinien/065-002_S2_Diagnostik_und_Therapie_der_Venenthrombose_und_der_Lungenembolie_06-2010_2_.pdf Zugriff: 30.4.2014
    PubMedGoogle Scholar
  • 566 Baird DD, Narendranathan M, Sandler RS. Increased risk of preterm birth for women with inflammatory bowel disease. Gastroenterology 1990; 99: 987-994
    PubMedGoogle Scholar
  • 567 Khosla R, Willoughby CP, Jewell DP. Crohn's disease and pregnancy. Gut 1984; 25: 52-56
    CrossrefPubMedGoogle Scholar
  • 568 Woolfson K, Cohen Z, McLeod RS. Crohn's disease and pregnancy. Dis Colon Rectum 1990; 33: 869-873
    CrossrefPubMedGoogle Scholar
  • 569 Hanan IM, Kirsner JB. Inflammatory bowel disease in the pregnant woman. Clin Perinatol 1985; 12: 669-682
    PubMedGoogle Scholar
  • 570 Fonager K, Sorensen HT, Olsen J et al. Pregnancy outcome for women with Crohn's disease: a follow-up study based on linkage between national registries. Am J Gastroenterol 1998; 93: 2426-2430
    CrossrefPubMedGoogle Scholar
  • 571 Baiocco PJ, Korelitz BI. The influence of inflammatory bowel disease and its treatment on pregnancy and fetal outcome. J Clin Gastroenterol 1984; 6: 211-216
    PubMedGoogle Scholar
  • 572 Larzilliere I, Beau P. Chronic inflammatory bowel disease and pregnancy. Case control study. Gastroenterologie clinique et biologique 1998; 22: 1056-1060
    PubMedGoogle Scholar
  • 573 Miller JP. Inflammatory bowel disease in pregnancy: a review. J R Soc Med 1986; 79: 221-225
    PubMedGoogle Scholar
  • 574 Akbari M, Shah S, Velayos FS et al. Systematic review and meta-analysis on the effects of thiopurines on birth outcomes from female and male patients with inflammatory bowel disease. Inflammatory Bowel Diseases 2013; 19: 15-22
    CrossrefPubMedGoogle Scholar
  • 575 Teruel C, Lopez-San Roman A, Bermejo F et al. Outcomes of pregnancies fathered by inflammatory bowel disease patients exposed to thiopurines. Am J Gastroenterol 2010; 105: 2003-2008
    CrossrefPubMedGoogle Scholar
  • 576 Mogadam M, Korelitz BI, Ahmed SW et al. The course of inflammatory bowel disease during pregnancy and postpartum. Am J Gastroenterol 1981; 75: 265-269
    PubMedGoogle Scholar
  • 577 Alstead EM. Inflammatory bowel disease in pregnancy. Postgrad Med J 2002; 78: 23-26
    CrossrefPubMedGoogle Scholar
  • 578 Narendranathan M, Sandler RS, Suchindran CM et al. Male infertility in inflammatory bowel disease. J Clin Gastroenterol 1989; 11: 403-406
    CrossrefPubMedGoogle Scholar
  • 579 O'Morain C, Smethurst P, Dore CJ et al. Reversible male infertility due to sulphasalazine: studies in man and rat. Gut 1984; 25: 1078-1084
    CrossrefPubMedGoogle Scholar
  • 580 Birnie GG, McLeod TI, Watkinson G. Incidence of sulphasalazine-induced male infertility. Gut 1981; 22: 452-455
    CrossrefPubMedGoogle Scholar
  • 581 Levi AJ, Fisher AM, Hughes L et al. Male infertility due to sulphasalazine. Lancet 1979; 2: 276-278
    PubMedGoogle Scholar
  • 582 Toth A. Reversible toxic effect of salicylazosulfapyridine on semen quality. Fertil Steril 1979; 31: 538-540
    PubMedGoogle Scholar
  • 583 van der Woude CJ, Kolacek S, Dotan I et al. European evidenced-based consensus on reproduction in inflammatory bowel disease. Journal of Crohn's & colitis 2010; 4: 493-510
    PubMedGoogle Scholar
  • 584 Srinath AI, Walter C, Newara MC et al. Pain management in patients with inflammatory bowel disease: insights for the clinician. Therap Adv Gastroenterol 2012; 5: 339-357
    CrossrefPubMedGoogle Scholar
  • 585 Tytgat GN. Hyoscine butylbromide: a review of its use in the treatment of abdominal cramping and pain. Drugs 2007; 67: 1343-1357
    CrossrefPubMedGoogle Scholar
  • 586 Streitberger K, Stuber F, Kipfer Buchli I et al. Drug therapy of acute and chronic abdominal pain. Therapeutische Umschau 2011; 68: 435-440
    CrossrefPubMedGoogle Scholar
  • 587 Arzneimittelkommission der deutschen Ärzteschaft. Agranulozytose nach Metamizol – sehr selten, aber häufiger als gedacht. Dtsch Arzteblatt 2011; 108: A1758-A1759
    PubMedGoogle Scholar
  • 588 Forrest K, Symmons D, Foster P. Systematic review: is ingestion of paracetamol or non-steroidal anti-inflammatory drugs associated with exacerbations of inflammatory bowel disease?. Aliment Pharmacol Ther 2004; 20: 1035-1043
    CrossrefPubMedGoogle Scholar
  • 589 White M, Shah N, Lindley K et al. Pain management in fulminating ulcerative colitis. Paediatr Anaesth 2006; 16: 1148-1152
    PubMedGoogle Scholar
  • 590 Long MD, Martin C, Sandler RS et al. Increased risk of pneumonia among patients with inflammatory bowel disease. American Journal of Gastroenterology 2013; 108: 240-248
    CrossrefPubMedGoogle Scholar
  • 591 Long MD, Barnes EL, Herfarth HH et al. Narcotic use for inflammatory bowel disease and risk factors during hospitalization. Inflammatory Bowel Diseases 2012; 18: 869-876
    CrossrefPubMedGoogle Scholar
  • 592 Jones JL, Loftus Jr EV . Avoiding the vicious cycle of prolonged opioid use in Crohn's disease. Am J Gastroenterol 2005; 100: 2230-2232
    CrossrefPubMedGoogle Scholar
  • 593 Bischoff SC, Koletzko B, Lochs H et al. S3-Leitlinie der Deutschen Gesellschaft für Ernährungsmedizin (DGEM) in Zusammenarbeit mit der Gesellschaft für klinische Ernährung der Schweiz (GESKES), der Österreichischen Arbeitsgemeinschaft für klinische Ernährung (AKE) und der Deutsche Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS). Aktuel Ernahrungsmed 2014; 39: e72-e98
    Article in Thieme ConnectPubMedGoogle Scholar
  • 594 Joos S, Brinkhaus B, Maluche C et al. Acupuncture and moxibustion in the treatment of active Crohn's disease: a randomized controlled study. Digestion 2004; 69: 131-139
    CrossrefPubMedGoogle Scholar
  • 595 Omer B, Krebs S, Omer H et al. Steroid-sparing effect of wormwood (Artemisia absinthium) in Crohn's disease: a double-blind placebo-controlled study. Phytomedicine 2007; 14: 87-95
    CrossrefPubMedGoogle Scholar
  • 596 Krebs S, Omer TN, Omer B. Wormwood (Artemisia absinthium) suppresses tumour necrosis factor alpha and accelerates healing in patients with Crohn's disease – A controlled clinical trial. Phytomedicine 2010; 17: 305-309
    CrossrefPubMedGoogle Scholar
  • 597 Gerhardt H, Seifert F, Buvari P et al. Therapy of active Crohn disease with Boswellia serrata extract H 15. Z Gastroenterol 2001; 39: 11-17
    Article in Thieme ConnectPubMedGoogle Scholar
  • 598 Holtmeier W, Zeuzem S, Preiss J et al. Randomized, placebo-controlled, double-blind trial of Boswellia serrata in maintaining remission of Crohn's disease: good safety profile but lack of efficacy. Inflamm Bowel Dis 2011; 17: 573-582
    CrossrefPubMedGoogle Scholar
  • 599 Turner D, Zlotkin SH, Shah PS et al. Omega 3 fatty acids (fish oil) for maintenance of remission in Crohn's disease. Cochrane Database Syst Rev 2009; DOI: 10.1002/14651858.CD006320.pub3.
    PubMedGoogle Scholar
  • 600 Rembacken BJ, Snelling AM, Hawkey PM et al. Non-pathogenic Escherichia coli versus mesalazine for the treatment of ulcerative colitis: a randomised trial. Lancet 1999; 354: 635-639
    CrossrefPubMedGoogle Scholar
  • 601 Kruis W, Schutz E, Fric P et al. Double-blind comparison of an oral Escherichia coli preparation and mesalazine in maintaining remission of ulcerative colitis. Aliment Pharmacol Ther 1997; 11: 853-858
    CrossrefPubMedGoogle Scholar
  • 602 Rolfe VE, Fortun PJ, Hawkey CJ et al. Probiotics for maintenance of remission in Crohn's disease. Cochrane Database Syst Rev 2006; DOI CD004826
    PubMedGoogle Scholar
  • 603 Butterworth AD, Thomas AG, Akobeng AK. Probiotics for induction of remission in Crohn's disease. Cochrane Database Syst Rev 2008; DOI: 10.1002/14651858.CD006634.pub2. CD006634
    PubMedGoogle Scholar