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Mediterranean diet and cancer

Published online by Cambridge University Press:  02 January 2007

Carlo La Vecchia
Carlo La Vecchia*
Affiliation:
Istituto di Ricerche Farmacologiche ‘Mario Negri’, via Eritrea 62, 20157 Milano, Italy Istituto di Statistica Medica e Biometria, Universita di Milano, Milano, Italy
*
*Corresponding author: Email lavecchia@marionegri.it
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Abstract

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Objective:

To analyse the role of various aspects of the Mediterranean diet in several common epithelial cancers, including digestive and selected non-digestive tract neoplasms.

Design:

Systematic analysis of data from a series of case-control studies.

Setting:

Northern Italy, between 1983 and 1998.

Subjects:

Over 12 000 cases of 20 cancer sites and 10 000 controls.

Results:

For most epithelial cancers, the risk decreased with increasing vegetable and fruit consumption, with relative risk (RR) between 0.3 and 0.7 for the highest versus the lowest tertile. For digestive tract cancers, population-attributable risks for low intake of vegetables and fruit ranged between 15 and 40%. A protective effect was observed also for breast, female genital tract, urinary tract and a few other epithelial neoplasms. A number of antioxidants and other micronutrients showed an inverse relationship with cancer risk, but the main components responsible for the favourable effect of a diet rich in vegetables and fruit remain undefined. Fish tended to be another favourable diet indicator. In contrast, subjects reporting frequent red meat intake showed RRs above unity for several common neoplasms. Intake of whole-grain foods was related to a reduced risk of several types of cancer, particularly of the upper digestive tract. This may be due to a favourable role of fibre, but the issue is still open to discussion. In contrast, refined grain intake and, consequently, glycaemic load and glycaemic index were associated with increased risk of different types of cancer including, among others, breast and colorectal.

Conclusions:

A low-risk diet for cancer in the Mediterranean would imply increasing the consumption of fruit and vegetables, as well as avoiding increasing the intakes of meat and refined carbohydrates. Further, olive oil and other unsaturated fats, which are also typical aspects of the Mediterranean diet, should be preferred to saturated ones.

Keywords

DietCancer preventionRiskEpidemiology
Type
Research Article
Information
Public Health Nutrition , Volume 7 , Issue 7 , October 2004 , pp. 965 - 968
Copyright
Copyright © The Authors 2004

References

1Trichopoulou, A, Lagiou, P, Kuper, H, Trichopoulos, D. Cancer and Mediterranean dietary traditions. Cancer Epidemiology, Biomarkers & Prevention 2000; 9: 869–73.Google ScholarPubMed
2La Vecchia, C, Chatenoud, L, Franceschi, S, Soler, M, Parazzini, F, Negri, E. Vegetables and fruit and human cancer: update of an Italian study. International Journal of Cancer 1999; 82: 151–2.3.0.CO;2-9>CrossRefGoogle ScholarPubMed
3Negri, E, La Vecchia, C, Franceschi, S, D'Avanzo, B, Talamini, R, Parpinel, M, et al. Intake of selected micronutrients and the risk of breast cancer. International Journal of Cancer 1996; 65: 140–4.3.0.CO;2-Z>CrossRefGoogle ScholarPubMed
4La Vecchia, C, Braga, C, Negri, E, Franceschi, S, Russo, A, Conti, E, et al. Intake of selected micronutrients and the risk of colorectal cancer. International Journal of Cancer 1997; 73: 525–30.3.0.CO;2-8>CrossRefGoogle ScholarPubMed
5Tavani, A, La Vecchia, C, Gallus, S, Lagiou, P, Trichopoulos, D, Levi, F, et al. Red meat intake and cancer risk: a study in Italy. International Journal of Cancer 2000; 86: 425–8.3.0.CO;2-S>CrossRefGoogle Scholar
6Fernandez, E, Chatenoud, L, La Vecchia, C, Negri, E, Franceschi, S. Fish consumption and cancer risk. American Journal of Clinical Nutrition 1999; 70: 85–90.CrossRefGoogle ScholarPubMed
7Chatenoud, L, Tavani, A, La Vecchia, C, Jacobs, DR Jr, Negri, E, Levi, F, et al. Whole grain food intake and cancer risk. International Journal of Cancer 1998; 77: 24–8.3.0.CO;2-1>CrossRefGoogle ScholarPubMed
8Negri, E, Franceschi, S, Parpinel, M, La Vecchia, C. Fibre intake and risk of colorectal cancer. Cancer Epidemiology, Biomarkers & Prevention 1998; 7: 667–71.Google ScholarPubMed
9Levi, F, Lucchini, F, Boyle, P, Negri, E, La Vecchia, C. Cancer incidence and mortality in Europe, 1988–92. Journal of Epidemiology and Biostatistics 1998; 3: 295–361.Google Scholar
10Franceschi, S, Russo, A, La Vecchia, C. Carbohydrates, fat and cancer of the breast and colon-rectum. Journal of Epidemiology and Biostatistics 1998; 3: 217–8.Google Scholar
11Giovannucci, E. Insulin and colon cancer. Cancer Causes & Control 1995; 6: 164–79.CrossRefGoogle ScholarPubMed
12Franceschi, S, Dal Maso, L, Augustin, L, Negri, E, Parpinel, M, Boyle, P, et al. Dietary glycemic load and colorectal cancer risk. Annals of Oncology 2001; 12: 173–8.CrossRefGoogle ScholarPubMed
13Augustin, LS, Dal Maso, L, La Vecchia, C, Parpinel, M, Negri, E, Vaccarella, S, et al. Dietary glycemic index and glycemic load, and breast cancer risk: a case-control study. Annals of Oncology 2001; 12: 1533–8.CrossRefGoogle ScholarPubMed
14La Vecchia, C, Negri, E, Franceschi, S, Decarli, A, Giacosa, A, Lipworth, L. Olive oil, other dietary fats, and the risk of breast cancer (Italy). Cancer Causes & Control 1995; 6: 545–50.CrossRefGoogle ScholarPubMed
15Prieto-Ramos, F, Serra-Majem, L, La Vecchia, C, Ramon, JM, Tresserras, R, Salieras, L. Mortality trends and past and current dietary factors of breast cancer in Spain. European Journal of Epidemiology 1996; 12: 141–8.CrossRefGoogle ScholarPubMed
16Trichopoulou, A. Olive oil and breast cancer. Cancer Causes &Control 1995; 6: 545–50.Google ScholarPubMed
17Braga, C, La Vecchia, C, Franceschi, S, Negri, E, Parpinel, M, Decarli, A, et al. Olive oil, other seasoning fats, and the risk of colorectal carcinoma. Cancer 1998; 82: 448–53.3.0.CO;2-L>CrossRefGoogle ScholarPubMed
18Franceschi, S, Favero, A, Conti, E, Talamini, R, Volpe, R, Negri, E, et al. Food groups, oils and butter, and cancer of the oral cavity and pharynx. British Journal of Cancer 1999; 80: 614–20.CrossRefGoogle ScholarPubMed
19Bosetti, C, La Vecchia, C, Talamini, R, Simonato, L, Zambon, P, Negri, E, et al. Food groups and risk of squamous cell esophageal cancer in Northern Italy. International Journal of Cancer 2000; 87: 289–94.3.0.CO;2-9>CrossRefGoogle ScholarPubMed
20Willett, WC. Diet and cancer: one view at the start of the millennium. Cancer Epidemiology, Biomarkers & Prevention 2001; 10: 3–8.Google ScholarPubMed
21Terry, P, Giovannucci, E, Michels, KB, Bergkvist, L, Hansen, H, Holmberg, L, et al. Fruit, vegetables, dietary fiber, and risk of colorectal cancer. Journal of the National Cancer Institute 2001; 93: 525–33.CrossRefGoogle ScholarPubMed
22La Vecchia, C. Nutrizione e Tumori. Implicazioni di Prevenzione e Prospettive di Ricerca. Rome: Il Pensiero Scientifico Editore, 1997.Google Scholar
23La Vecchia, C, Chatenoud, L, Altieri, A, Tavani, A. Nutrition and health: epidemiology of diet, cancer and cardiovascular disease in Italy. Nutrition, Metabolism, and Cardiovascular Diseases 2001; 11(Suppl. 4): 10–5.Google ScholarPubMed