Chest
Original ResearchCOPDDepressive Symptoms as Predictors of Mortality in Patients With COPD
Section snippets
Subjects
Our study sample consisted of 121 consecutive stable patients, all with COPD (FEV1 < 80% predicted) that had been diagnosed according to the American Thoracic Society guidelines,28 who were referred for pulmonary rehabilitation between September 1998 and March 2000. All patients had been clinically stable for at least 6 weeks and did not require an increase in medication or hospitalization. Exclusion criteria were the inability to perform lung function tests and/or ergometry, refusal to fill
Results
The characteristics of the patients (78 men and 43 women) are presented in Table 1. The mean age was 61.5 ± 9.1 years. Their post-bronchodilator therapy FEV1 was 36.9 ± 15.5% predicted. With regard to depression, 19.8% of patients tested above the standard cutoff score of ≥ 19 and were classified as having moderate-to-severe depressive symptoms.
Of the 121 patients who participated in the study, 76 (63%) had died at the end of the study. The median survival time for all patients was 5.3 years.
Discussion
This study provides preliminary evidence that depressive symptoms are an independent prognostic factor for mortality among stable COPD patients, even when adjustments are made for risk factors such as age, sex, and Wpeak. The association of depressive symptoms and mortality has been demonstrated in COPD patients assessed during or shortly after hospitalization for an exacerbation. However, to our knowledge, this is one of the first studies demonstrating that there is an association even in
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The authors have reported to the ACCP that no significant conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article.
The preparation of this article was funded by the Beatrixoord Foundation, Haren, the Netherlands.
Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (www.chestjournal.org/misc/reprints.shtml).