Potential applications of matrix metalloproteinase inhibitors in geriatric practice

Galina Marder; Robert A Greenwald

Potential applications of matrix metalloproteinase inhibitors in geriatric practice

Isr Med Assoc J. 2003 May;5(5):361-4.

Authors

Galina Marder¹, Robert A Greenwald

Affiliation

¹ Department of Rheumatology, Long Island Jewish Medical Center, New York, NY, USA. marder@lij.edu, rgreen@lij.edu

PMID: 12811957

Abstract

Matrix metalloproteinases are a family of enzymes that degrade different components of extracellular matrix. They play an important role in normal physiologic processes of maintaining tissue integrity and remodeling, as in wound healing, processes of development, and regeneration. However, excessive expression of MMP has been observed in many disease states, including rheumatoid arthritis and osteoarthritis, vascular remodeling in atherosclerosis and aortic aneurysm formation, neoplastic processes, macular degeneration and many others.

Publication types

Review

MeSH terms

Aged
Aortic Aneurysm / etiology
Aortic Aneurysm / physiopathology*
Aortic Aneurysm / prevention & control*
Geriatrics*
Humans
Macular Degeneration / etiology
Macular Degeneration / physiopathology*
Macular Degeneration / prevention & control*
Matrix Metalloproteinase Inhibitors*
Matrix Metalloproteinases / physiology*
Osteoarthritis / etiology
Osteoarthritis / physiopathology*
Osteoarthritis / prevention & control*
Practice Patterns, Physicians'*
Risk Factors

Substances

Matrix Metalloproteinase Inhibitors
Matrix Metalloproteinases