Abstract
We conducted a pilot randomized controlled trial comparing trimethoprim-sulfamethoxazole to benzathine penicillin for treatment of impetigo in Aboriginal children. Treatment was successful in 7 of 7 children treated with trimethoprim-sulfamethoxazole and 5 of 6 treated with benzathine penicillin. Trimethoprim-sulfamethoxazole achieved microbiological clearance and healing of sores from which beta-hemolytic streptococci and community-associated methicillin-resistant Staphylococcus aureus were initially cultured.
Publication types
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Comparative Study
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Administration, Oral
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Adolescent
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Anti-Infective Agents / administration & dosage
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Anti-Infective Agents / therapeutic use*
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Child
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Child, Preschool
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Female
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Humans
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Impetigo / drug therapy*
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Impetigo / microbiology
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Infant
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Injections, Intramuscular
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Male
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Methicillin-Resistant Staphylococcus aureus
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Native Hawaiian or Other Pacific Islander*
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Northern Territory
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Penicillin G Benzathine / administration & dosage
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Penicillin G Benzathine / therapeutic use*
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Pilot Projects
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Streptococcus pyogenes
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Trimethoprim, Sulfamethoxazole Drug Combination / administration & dosage
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Trimethoprim, Sulfamethoxazole Drug Combination / therapeutic use*
Substances
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Anti-Infective Agents
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Trimethoprim, Sulfamethoxazole Drug Combination
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Penicillin G Benzathine