The Clinical High-Risk State for Psychosis (CHR-P), Version II

Paolo Fusar-Poli

doi:10.1093/schbul/sbw158

The Clinical High-Risk State for Psychosis (CHR-P), Version II

Schizophr Bull. 2017 Jan;43(1):44-47. doi: 10.1093/schbul/sbw158.

Author

Paolo Fusar-Poli^{1

2}

Affiliations

¹ Department of Psychosis Studies, Institute of Psychiatry , Psychology and Neuroscience, King's College London, London, UK; paolo.fusar-poli@kcl.ac.uk.
² OASIS Service, South London and the Maudsley NHS Foundation Trust, London, UK.

Abstract

The Clinical High-Risk state for psychosis (CHR-P) paradigm was introduced about 2 decades ago. Over this period of time accumulating knowledge has been gained. Conceptual advancements involve new knowledge into risk enrichment and the impact of recruitment strategies, specificity for prediction of psychotic and nonpsychotic mental disorders and heterogeneity of psychosis risk among the different CHR-P subgroups. The current special issue advances current knowledge on deconstructing the CHR-P paradigm across its 3 subgroups: genetic risk, attenuated psychotic symptoms, and short-lived and remitting psychotic episodes. A conceptual revision of the paradigm (Version II) is suggested and supported by 3 original studies published in this special issue.

Keywords: ARMS; SIPS; UHR; psychosis; risk; schizophrenia.

Publication types

Introductory Journal Article

MeSH terms

Humans
Practice Guidelines as Topic*
Psychotic Disorders* / diagnosis
Psychotic Disorders* / epidemiology
Psychotic Disorders* / physiopathology
Risk Assessment*
Schizophrenia* / diagnosis
Schizophrenia* / epidemiology
Schizophrenia* / physiopathology