Perspective view of allogeneic IgG tumor immunotherapy

Ying Liu; Yuanyi Huang; Hong-Wei Cui; YingYing Wang; ZhaoWu Ma; Ying Xiang; Hong-Yi Xin; Jun-Qing Liang; Hong-Wu Xin

doi:10.1186/s12935-024-03290-9

Perspective view of allogeneic IgG tumor immunotherapy

Cancer Cell Int. 2024 Mar 9;24(1):100. doi: 10.1186/s12935-024-03290-9.

Authors

Ying Liu^#^{1

2

3}, Yuanyi Huang^#¹, Hong-Wei Cui^#⁴, YingYing Wang⁵, ZhaoWu Ma^{2

3}, Ying Xiang^{2

3}, Hong-Yi Xin^{6

7}, Jun-Qing Liang⁸, Hong-Wu Xin^{9

10}

Affiliations

¹ Department of Radiology, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou, 434000, Hubei, China.
² Laboratory of Oncology, School of Basic Medicine, Center for Molecular Medicine, Health Science Center, Yangtze University, Jingzhou, 434023, Hubei, China.
³ Department of Biochemistry and Molecular Biology, School of Basic Medicine, Health Science Center, Yangtze University, Jingzhou, 434023, Hubei, China.
⁴ Center for Breast Cancer, Peking University Cancer Hospital at Inner Mongolia Campus and Affiliated Cancer Hospital of Inner Mongolia Medical University, Hohhot, 010021, Inner Mongolia, China.
⁵ Division of Life Sciences and Medicine, Department of Obstetrics and Gynecology, Core Facility Center, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, Anhui, China.
⁶ The Doctoral Scientific Research Center, People's Hospital of Lianjiang, Guangdong, 524400, China. hongyi_xin@126.com.
⁷ The Doctoral Scientific Research Center, People's Hospital of Lianjiang, Guangdong Medical University, Guangdong, 524400, China. hongyi_xin@126.com.
⁸ Center for Breast Cancer, Peking University Cancer Hospital at Inner Mongolia Campus and Affiliated Cancer Hospital of Inner Mongolia Medical University, Hohhot, 010021, Inner Mongolia, China. Liang_junqing@126.com.
⁹ Laboratory of Oncology, School of Basic Medicine, Center for Molecular Medicine, Health Science Center, Yangtze University, Jingzhou, 434023, Hubei, China. hongwu_xin@126.com.
¹⁰ Key Laboratory of Human Genetic Diseases Research of Inner Mongolia, Research Centre of Molecular Medicine, Medical College of Chifeng University, Chifeng, 024000, Inner Mongolian Autonomous Region, China. hongwu_xin@126.com.

^# Contributed equally.

Abstract

Allogeneic tumors are eradicated by host immunity; however, it is unknown how it is initiated until the report in Nature by Yaron Carmi et al. in 2015. Currently, we know that allogeneic tumors are eradicated by allogeneic IgG via dendritic cells. AlloIgG combined with the dendritic cell stimuli tumor necrosis factor alpha and CD40L induced tumor eradication via the reported and our proposed potential signaling pathways. AlloIgG triggers systematic immune responses targeting multiple antigens, which is proposed to overcome current immunotherapy limitations. The promising perspectives of alloIgG immunotherapy would have advanced from mouse models to clinical trials; however, there are only 6 published articles thus far. Therefore, we hope this perspective view will provide an initiative to promote future discussion.

Keywords: Allogeneic IgG; Antigen presentation; Dendritic cell; FcγR; Tumor immunotherapy.

Publication types

Review

Abstract

Publication types

Grants and funding