Triggering of tumour cell apoptosis is the foundation of many cancer therapies. Death receptors
of the tumour necrosis factor (TNF) superfamily have been largely characterized, as have …

Allergen immunotherapy (AIT) has been used to treat allergic disease since the early 1900s.
Despite numerous clinical trials and meta-analyses proving AIT efficacious, it remains …

Risk assessment of individuals with anaphylaxis is currently hampered by lack of (1) an
optimal and readily available laboratory test to confirm the clinical diagnosis of an anaphylaxis …

We have used immunohistochemistry and monoclonal antibodies to analyze the phenotypic
composition and activation status of the cellular infiltrate of bronchial biopsies obtained by …

Airway wall remodeling is an established pathological feature in asthma. Its causes are not
well understood, but one mediator of potential relevance is transforming growth factor-beta 1 (…

OBJECTIVE--To evaluate the efficacy and safety of immunotherapy (hyposensitisation) in
patients with severe summer hay fever. DESIGN--A randomised, double blind, placebo …

We have studied the influence of grass pollen immunotherapy on cellular infiltration and
cytokine mRNA expression during allergen-induced late-phase cutaneous responses. In a …

BACKGROUND: Specific immunotherapy is widely used to treat allergic rhinitis, but few
large-scale clinical trials have been performed. OBJECTIVE: We sought to assess the efficacy …

We have previously demonstrated that short-term exposure to diesel exhaust (DE) for 1 h
induced a marked leukocytic infiltration in the airways of healthy human volunteers involving …

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