In many randomised trials researchers measure a continuous variable at baseline and
again as an outcome assessed at follow up. Baseline measurements are common in trials of …

Background Although acupuncture is widely used for chronic pain, there remains considerable
controversy as to its value. We aimed to determine the effect size of acupuncture for 4 …

Despite wide use in clinical practice, acupuncture remains a controversial treatment for chronic
pain. Our objective was to update an individual patient data meta-analysis to determine …

The methods and results of health research are documented in study protocols, full study
reports (detailing all analyses), journal reports, and participant-level datasets. However, …

Many decisions in medicine involve trade-offs, such as between diagnosing patients with
disease versus unnecessary additional testing for those who are healthy. Net benefit is an …

Testing for prostate-specific antigen (PSA) has profoundly affected the diagnosis and treatment
of prostate cancer. PSA testing has enabled physicians to detect prostate tumours while …

Background Acupuncture is often used for prevention of tension‐type headache but its
effectiveness is still controversial. This is an update of our Cochrane review originally published …

Background Acupuncture is often used for migraine prophylaxis but its effectiveness is still
controversial. This review (along with a companion review on'Acupuncture for tension‐type …

Purpose The long-term risk of prostate cancer–specific mortality (PCSM) after radical
prostatectomy is poorly defined for patients treated in the era of widespread prostate-specific …

Objective To determine the relation between concentrations of prostate specific antigen at
age 60 and subsequent diagnosis of clinically relevant prostate cancer in an unscreened …