The retina provides exquisitely sensitive vision that relies on the integrity of a uniquely
vulnerable cell, the photoreceptor (PR). The genetic and mechanistic causes of retinal …

The difficulty of identifying susceptibility genes for common diseases has polarized geneticists'
views on what disease models are appropriate and how best to proceed once high-…

The association of more than 140 genes with human photoreceptor degenerations, together
with studies of animal models of these monogenic diseases, has provided great insight into …

Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density
lipoprotein cholesterol and triglycerides are among the most important risk factors for …

Elastic constants for zinc-blende and wurtzite AlN, GaN, and InN are obtained from density-functional-theory
calculations utilizing ab initio pseudopotentials and plane-wave expansions…

… This is estimated with Wright’s path method,19 which calculates an individual’s probability of
inheriting two IBD alleles, … Fped was calculated for each individual via Wright’s path method.…

Background Age-related macular degeneration is the most common cause of blindness in
Western populations. Susceptibility is influenced by age and by genetic and environmental …

Uric acid is the end product of purine metabolism in humans and great apes, which have
lost hepatic uricase activity, leading to uniquely high serum uric acid concentrations (200–500 …

Chronic kidney disease (CKD) is a significant public health problem, and recent genetic studies
have identified common CKD susceptibility variants. The CKDGen consortium performed …

Smoking is a leading global cause of disease and mortality 1 . We established the Oxford-GlaxoSmithKline
study (Ox-GSK) to perform a genome-wide meta-analysis of SNP association …