User profiles for A. McKnight

Aine McKnight

Professor of Viral Pathology
Verified email at qmul.ac.uk
Cited by 9208

Cell surface receptors, virus entry and tropism of primate lentiviruses

PR Clapham, Á McKnight - Journal of General Virology, 2002 - microbiologyresearch.org
Human immunodeficiency virus (HIV) exploits cell surface receptors to attach to and gain entry
into cells. The HIV envelope spike glycoprotein on the surface of virus particles binds both …

The orphan opioid receptor and its endogenous ligand—nociceptin/orphanin FQ

G Henderson, AT McKnight - Trends in pharmacological sciences, 1997 - cell.com
Following the elucidation of the amino acid sequences of the μ-, δ- and κ-opioid receptors, a
new ‘orphan opioid receptor' was cloned with a high degree of homology to the ‘classical' …

HIV-1 receptors and cell tropism

PR Clapham, Á McKnight - British medical bulletin, 2001 - academic.oup.com
HIV virus particles interact with several receptors on cell surfaces. Two receptors, CD4 and
a co-receptor act sequentially to trigger fusion of viral and cellular membranes and confer …

Immune boosting by B. 1.1. 529 (Omicron) depends on previous SARS-CoV-2 exposure

…, A Semper, T Brooks, Á McKnight… - Science, 2022 - science.org
The Omicron, or Pango lineage B.1.1.529, variant of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) carries multiple spike mutations with high transmissibility and …

[HTML][HTML] Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2

…, JC Moon, L van Dorp, F Balloux, Á McKnight… - Nature, 2022 - nature.com
Individuals with potential exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
do not necessarily develop PCR or antibody positivity, suggesting that some …

Young novice drivers: careless or clueless?

AJ McKnight, AS McKnight - Accident Analysis & Prevention, 2003 - Elsevier
The per-mile accident rate of 16-year-old novices is approximately 10 times that of adults, a
difference that has been attributed to the immaturity of youth and the errors of inexperience. …

Prior SARS-CoV-2 infection rescues B and T cell responses to variants after first vaccine dose

…, AM Valdes, Á McKnight… - Science, 2021 - science.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine rollout has coincided
with the spread of variants of concern. We investigated whether single-dose vaccination, …

The effect of cellular phone use upon driver attention

AJ McKnight, AS McKnight - Accident Analysis & Prevention, 1993 - Elsevier
In this study, 150 subjects observed a 25-minute video driving sequence containing 45
highway traffic situations to which they were expected to respond by manipulation of simulated …

[HTML][HTML] Antibody response to first BNT162b2 dose in previously SARS-CoV-2-infected individuals

C Manisty, AD Otter, TA Treibel, Á McKnight… - The Lancet, 2021 - thelancet.com
Most vaccine platforms use a two-dose prime-boost approach to generate an immune
response against the virus S1 spike protein, the titres of which correlate with functional virus …

[HTML][HTML] CD4-independent infection by HIV-2 is mediated by fusin/CXCR4

…, M Marsh, M Ahuja, JD Turner, A McKnight… - Cell, 1996 - cell.com
Several members of the chemokine receptor family have been shown to function in association
with CD4 to permit HIV-1 entry and infection. However, the mechanism by which these …