Proton pump inhibitors are one of the most frequently prescribed classes of drug in the world
because they combine a high level of efficacy with low toxicity. In 2006, expenditure on …

BACKGROUND: A combination of midazolam and opioid is usually used to achieve sedation
and analgesia during colonoscopy. Two commonly used opioids are meperidine and …

Background Thioguanine (TG) is a thiopurine which has been used for patients with inflammatory
bowel disease (IBD), who have failed azathioprine (AZA) or mercaptopurine (MP) due …

Purpose The fluoropyrimidines have been extensively used for almost five decade worldwide
for the treatment of solid cancers. However, severe toxicity is a major clinical problem and …

Background: In inflammatory bowel disease (IBD), conventional thiopurine users cease
treatment in 60% of cases within 5 years, mostly because of adverse events or nonresponse. In …

One in 10 patients attends general practice with gastrointestinal symptoms. 1 Irritable bowel
syndrome (IBS) is typified by abdominal discomfort or pain, and bloating with disturbed …

Discussion First described by Eugene Devic in 1894, NMO is a rare, chronic inflammatory,
demyelinating disease of the central nervous system. 1 It is more common among Asians and …

The article presents a case study of a 49-year-old man who presented with a 3-day history
of increased lethargy, jaundice and oedema and undiagnosed ulcerative colitis. Blood film …

Introduction Chronic diarrhoea is an indication for referral on the Colorectal two week wait (TWW)
pathway for suspected malignancy. Microscopic colitis (MC) characteristically presents …