The clinical relevance of human papillomavirus testing: relationship between analytical and clinical sensitivity

PJF Snijders, AJC van den Brule… - The Journal of …, 2003 - Wiley Online Library
Given the fact that infection with high‐risk human papillomavirus (HPV) is causally involved
in cervical cancer, addition of high‐risk HPV testing to a cervical smear may improve the …

Pathogenic roles for Epstein–Barr virus (EBV) gene products in EBV-associated proliferative disorders

JM Middeldorp, AATP Brink, AJC Van den Brule… - Critical reviews in …, 2003 - Elsevier
Epstein–Barr virus (EBV) is associated with a still growing spectrum of clinical disorders,
ranging from acute and chronic inflammatory diseases to lymphoid and epithelial malignancies. …

The use of general primers GP5 and GP6 elongated at their 3′ ends with adjacent highly conserved sequences improves human papillomavirus detection by PCR

…, AJC van den Brule… - Journal of general …, 1995 - microbiologyresearch.org
Sequence analysis of human papillomavirus (HPV) general primer GP5/6 mediated PCR
products revealed the presence of short highly conserved sequences adjacent to the 3′ ends …

[HTML][HTML] Sexually transmitted infection as a cause of anal cancer

M Frisch, B Glimelius, AJC van den Brule… - … England Journal of …, 1997 - Mass Medical Soc
Background The incidence of anal cancer has increased in recent decades, particularly
among women. To identify underlying risk factors, we conducted a population-based case–…

GP5+/6+ PCR followed by reverse line blot analysis enables rapid and high-throughput identification of human papillomavirus genotypes

AJC van den Brule, R Pol… - Journal of clinical …, 2002 - Am Soc Microbiol
In this study, we developed a simple and fast typing procedure for 37 mucosotropic human
papillomavirus (HPV) types using a nonradioactive reverse line blotting (RLB) procedure for …

Type specific persistence of high risk human papillomavirus (HPV) as indicator of high grade cervical squamous intraepithelial lesions in young women: population …

SK Kjaer, AJC Van den Brule, G Paull, EI Svare… - Bmj, 2002 - bmj.com
Objectives: To investigate the role of human papillomavirus (HPV) in the development of
cervical neoplasia in women with no previous cervical cytological abnormalities; whether the …

Herpes simplex virus-2 as a human papillomavirus cofactor in the etiology of invasive cervical cancer

…, CJLM Meijer, AJC Van den Brule… - Journal of the …, 2002 - academic.oup.com
Background: Human papillomavirus (HPV) infection is the main cause of invasive cervical
cancer, but cofactors may act in conjunction with HPV. We performed a pooled analysis of …

Overestimation of complication rates in evaluations of Chlamydia trachomatis screening programmes—implications for cost-effectiveness analyses

…, SA Morré, AJC van den Brule… - International journal …, 2004 - academic.oup.com
Background Cost-effectiveness analyses of screening programmes for asymptomatic Chlamydia
trachomatis infection suggest that screening at low prevalences in the population is cost…

The use of general primers in the polymerase chain reaction permits the detection of a broad spectrum of human papillomavirus genotypes

PJF Snijders, AJC van den Brule… - Journal of General …, 1990 - microbiologyresearch.org
A novel polymerase chain reaction (PCR) method was developed that permits the detection
of 11 different human papillomavirus (HPV) genotypes using two general primer sets. By …

High-risk human papillomavirus is sexually transmitted: evidence from a follow-up study of virgins starting sexual activity (intercourse)

…, B Chackerian, AJC Van Den Brule… - … Biomarkers & Prevention, 2001 - AACR
Genital human papillomavirus (HPV) infection is generally considered to be sexually
transmitted. However, nonsexual spread of the virus has also been suggested. The goal of this …