The 1971 preliminary criteria for the classification of systemic lupus erythematosus (SLE)
were revised and updated to incorporate new immunologic knowledge and improve disease …

Immune thrombocytopenia (ITP) is commonly encountered in clinical practice. In 1996 the
American Society of Hematology published a landmark guidance paper designed to assist …

Rudolph Virchow, in 1854, introduced and popularized the term amyloid to denote a macroscopic
tissue abnormality that exhibited a positive iodine staining reaction. Subsequent light …

Background Effective ways to prevent arthropathy in severe hemophilia are unknown.
Methods We randomly assigned young boys with severe hemophilia A to regular infusions of …

Background The prognosis of patients with homozygous β-thalassemia (thalassemia major)
has been improved by transfusion and iron-chelation therapy. We analyzed outcome and …

The immune system is the most important protective physiological system of the organism. It
has many connections with other systems and is, in fact, often considered as part of the …

AMYLOIDOSIS in man and animals may be associated with other disease entities or may
occur spontaneously. The relationship, if any, of the different forms of amyloid has proved …

Deferasirox (ICL670) is a once-daily oral iron chelator developed for the treatment of
chronic iron overload from blood transfusions. A comparative phase 3 trial was conducted to …

Abstract Treatment of patients with β-thalassemia major has improved dramatically during
the past 40 years; however, the current clinical status of these patients remains poorly …

Operational methods have been used for over a century to solve problems such as ordinary
and partial differential equations. When solving such problems, in many cases it is fairly …