In the last decade we have witnessed a dramatic increase in the proportion and absolute
number of bacterial pathogens resistant to multiple antibacterial agents. Multidrug-resistant …

EUCAST expert rules have been developed to assist clinical microbiologists and describe
actions to be taken in response to specific antimicrobial susceptibility test results. They include …

Since their discovery in the early 1960s, the quinolone group of antibacterials has generated
considerable clinical and scientific interest. Nalidixic acid, the first quinolone to be …

The pharmacokinetics of tetracyclines and glycylcyclines are described in three groups.
Group 1, the oldest group, represented by tetracycline, oxytetracycline, chlortetracycline, …

… Alasdair P. MacGowan … MacGowan, Johan W. Mouton, Anders Österlund, Arne Rodloff,
Martin Steinbakk, Pavla Urbaskova, Alkiviadis Vatopoulos, European harmonization of MIC …

The sensitivity and specificity of seven methods (agar dilution, broth microdilution, Etest at
0.5 and 2.0 McFarland (McF) inocula, two agar screening methods, and population studies [PS…

Gram-positive organisms, particularly staphylococci and streptococci, are responsible for the
majority of bone and joint infections. Treatment of these infections can be difficult, usually …

The pharmacokinetics and pharmacodynamics of linezolid have been extensively investigated
in laboratory models, healthy volunteers and patients. Three formulations exist: an …

Antimicrobial resistance continues to increase while the pipeline for new antibiotic development
is drying up; after only eight decades of antibiotic use, bacterial infections that once …

There is a growing need to optimize the use of old and new antibiotics to treat serious as well
as less serious infections. The topic of how to use pharmacokinetic and pharmacodynamic (…