A novel series of HDAC inhibitors demonstrating class I subtype selectivity and good oral
bioavailability is described. The compounds are potent enzyme inhibitors (IC 50 values less …

Fragment-based screening identified 7-azaindole as a protein kinase B inhibitor scaffold.
Fragment elaboration using iterative crystallography of inhibitor−PKA−PKB chimera complexes …

The therapeutic and toxic effects of drugs are often generated through effects on distinct cell
types in the body. Selective delivery of drugs to specific cells or cell lineages would, …

6-Phenylpurines were identified as novel, ATP-competitive inhibitors of protein kinase B (PKB/Akt)
from a fragment-based screen and were rapidly progressed to potent compounds …

Lacto-N-neo-difucohexaose II, β-d-Galp-(1→4)-[α-l-Fucp-(1→3)]-β-d-GlcpNAc-(1→3)-β-d-Galp-(1→4)-[α-l-Fucp-(1→3)]-
d-Glc, and 3′-galactosyllactose, β-d-Galp-(1→3)-β-d-Galp-(1→…

Many human cancers over-express B cell lymphoma 2 (Bcl-2) or X-linked inhibitor of
apoptosis (IAP) proteins to evade cell death. The pro-apoptotic ARTS (Sept4_i2) protein binds …

1. The action of dilute H2O2 on a series of ovarian-cyst glycoproteins and glycopolypeptides
was investigated. 2. Both native glycoproteins and the glycopolypeptides were carbohydrate…

The oligosaccharides obtained from human milk are of intrinsic interest because some of
them carry the H, Le” and Leb blood group determinants. They have also been used …

Blood‐group‐specific glycoproteins obtained from ovarian cyst fluids of A 1 and A 2 persons
were degraded with NaOH/NaBH 4 . The oligosaccharides releasecd were de‐products …

Structure-based drug design of novel isoquinoline-5-sulfonamide inhibitors of PKB as potential
antitumour agents was investigated. Constrained pyrrolidine analogues that mimicked …