Background Chronic pain is recognised as an important problem in the community but our
understanding of the epidemiology of chronic pain remains limited. We undertook a study …

This guidance document reviews the epidemiology and management of pain in older people
via a literature review of published research. The aim of this document is to inform health …

Background. Chronic pain is known to be very common in the community. Less is known about
the epidemiology of more significant or severe chronic pain. The impact of chronic pain in …

Objective To examine the absolute risks or benefits on cancer associated with oral contraception,
using incident data. Design Inception cohort study. Setting Royal College of General …

Objective To see if the mortality risk among women who have used oral contraceptives
differs from that of never users. Design Prospective cohort study started in 1968 with mortality …

Previous research has clearly demonstrated a link between chronic pain and poor health,
and has suggested a link with increased mortality, though the latter is less consistent. In 1996 …

Deworming is rightly advocated to prevent helminth-induced morbidity. Nevertheless, in affluent
countries, the deliberate infection of patients with worms is being explored as a possible …

Background Modern demands and challenges among healthcare professionals can be
particularly stressful and resilience is increasingly necessary to maintain an effective, adaptable, …

Background Trials done in infants with low birthweight in west Africa suggest that BCG
vaccination reduces all-cause mortality in the neonatal period, probably because of heterologous …

Histone lysine methyltransferases (KMTs) and demethylases (KDMs) underpin gene regulation.
Here we demonstrate that variants causing haploinsufficiency of KMTs and KDMs are …