Mutations in mitochondrial DNA (mtDNA) are a common cause of genetic disease. Pathogenic
mutations in mtDNA are detected in approximately 1 in 250 live births 1 , 2 , 3 and at least …

The homeobox transcription factor Nanog has been proposed to play a crucial role in the
maintenance of the undifferentiated state of murine embryonic stem cells. A human counterpart, …

Mitochondrial DNA (mtDNA) mutations are maternally inherited and are associated with a
broad range of debilitating and fatal diseases 1 . Reproductive technologies designed to …

In mitosis, the spindle checkpoint protein Mad2 averts aneuploidy by delaying anaphase
onset until chromosomes align. Here we show that depletion of Mad2 in meiosis I mouse …

Human embryonic stem cells (hESCs) have great potential as a source of cells for therapeutic
uses, but their culture requires the support of mouse or human cells, either directly as a …

Disjunction of pairs of homologous chromosomes during the first meiotic division (MI) requires
anaphase-promoting complex (APC)-mediated activation of separase in budding yeast 1 , …

Background. Our current knowledge of the epidemiology of infertility is limited and outdated.
Health care provision for infertility in the UK attracts public interest because of restrictions on …

Human embryonic stem cells (hESCs) have been derived from the inner cell mass (ICM) of
day 5–7 blastocysts and hold great promise for research into human developmental biology …

Young people with cerebral palsy (CP) are often assumed to have low self-concept, in other
words, they do not feel good about themselves. We systematically searched the literature to …

Human embryonic stem (hES) cells are pluripotent cells derived from the inner cell mass
cells of blastocysts with the potential to maintain an undifferentiated state indefinitely. Fully …