The factors driving therapy resistance in diffuse glioma remain poorly understood. To
identify treatment-associated cellular and genetic changes, we analyzed RNA and/or DNA …

The evolutionary processes that drive universal therapeutic resistance in adult patients with
diffuse glioma remain unclear 1 , 2 . Here we analysed temporally separated DNA-…

Aims Glioblastoma (GBM) is the most common and aggressive primary malignant brain
tumour in adults, with a poor prognosis. Changing treatment paradigms suggest improved …

The ability to diagnose cancer rapidly with high sensitivity and specificity is essential to
exploit advances in new treatments to lead significant reductions in mortality and morbidity. …

The surgical management of recurrent glioblastoma multiforme is controversial. Recent
publications suggest that re-operation provides 3–5 months median survival, without significant …

Gliomas are the most frequent primary brain tumours in adults with over 9,000 people
diagnosed each year in the UK. A rapid, reagent‐free and cost‐effective diagnostic regime using …

<p>This study was conducted to determine whether local arterial pulsations are sufficient to
cause cerebrospinal fluid (CSF) flow along perivascular spaces (PVS) within the spinal cord. …

Background Insertion of a ventriculoperitoneal shunt for hydrocephalus is one of the commonest
neurosurgical procedures worldwide. Infection of the implanted shunt affects up to 15% …

Objectives: To evaluate the role of endoscopic third ventriculostomy (ETV) as a primary
treatment for hydrocephalus in children less than 1 year old and to determine its impact as a …

Background Incidental discovery accounts for 30% of newly-diagnosed intracranial meningiomas.
There is no consensus on their optimal management. This review aimed to evaluate …