Background and Purpose— Disease of the cardiovascular system is the main cause of long-term
complications and mortality in patients with type I (insulin-dependent) and type II (non-…

OBJECTIVE—Mortality from acute diabetes-related events is greatly raised in young adults
with type 1 diabetes. Psychosocial and socioeconomic risk factors are examined for deaths …

1. An increase in capillary blood flow and pressure has been implicated in the pathogenesis
of diabetic microangiopathy. Abnormal vascular reactivity of the resistance vasculature may …

Cleanroom processing techniques have been used to mass-produce flexible,
electroenzymatic glucose sensors designed for implantation in subcutaneous tissue. In vitro …

Background: Both executive function deficits and slower processing speed are characteristic
of children with fetal alcohol exposure, but the temporal dynamics of neural activity …

Protein delivery into cells is a potentially transformative tool for treating “undruggable” targets
in diseases associated with protein deficiencies or mutations. The vast majority of these …

Topoisomerase II is a ubiquitous enzyme that is essential for the survival of all eukaryotic
organisms and plays critical roles in virtually every aspect of DNA metabolism. The enzyme …

… burden of disease caused by group A streptococcus (GAS) is not known. We review recent
population-based data to estimate the burden … The greatest burden is due to rheumatic heart …

Topoisomerase II is the target for several highly active anticancer drugs that induce cell
death by enhancing enzyme-mediated DNA scission. Although these agents dramatically …

… presents a major ongoing burden to public health. … , the multiplier and the resulting burden
of illness estimate will increase. … overestimate the burden of illness imposed by Salmonella. …