Everyday ethics in community-based participatory research
…, T Holland, C Holmes, A Lee, A McNulty… - … and Social Sciences, 2016 - taylorfrancis.com
This article explores a range of ethical issues that arise in community-based participatory
research (CBPR), drawing on literature and examples from practice. The experience of CBPR …
research (CBPR), drawing on literature and examples from practice. The experience of CBPR …
The protein kinase Cβ–selective inhibitor, enzastaurin (LY317615. HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of …
JR Graff, AM McNulty, KR Hanna, BW Konicek… - Cancer research, 2005 - AACR
Activation of protein kinase Cβ (PKCβ) has been repeatedly implicated in tumor-induced
angiogenesis. The PKCβ-selective inhibitor, Enzastaurin (LY317615.HCl), suppresses …
angiogenesis. The PKCβ-selective inhibitor, Enzastaurin (LY317615.HCl), suppresses …
[HTML][HTML] Increased AKT activity contributes to prostate cancer progression by dramatically accelerating prostate tumor growth and diminishing p27Kip1 expression
JR Graff, BW Konicek, AM McNulty, Z Wang… - Journal of Biological …, 2000 - ASBMB
The PTENtumor suppressor gene is frequently inactivated in human prostate cancers,
particularly in more advanced cancers, suggesting that the AKT/protein kinase B (PKB) kinase, …
particularly in more advanced cancers, suggesting that the AKT/protein kinase B (PKB) kinase, …
[HTML][HTML] Therapeutic suppression of translation initiation factor eIF4E expression reduces tumor growth without toxicity
…, S Sissons, K Cox, AM McNulty… - The Journal of …, 2007 - Am Soc Clin Investig
Increased cap-dependent mRNA translation rates are frequently observed in human cancers.
Mechanistically, many human tumors often overexpress the cap binding protein eukaryotic …
Mechanistically, many human tumors often overexpress the cap binding protein eukaryotic …
eIF4E activation is commonly elevated in advanced human prostate cancers and significantly related to reduced patient survival
…, RL Lynch, CA Dumstorf, MS Dowless, AM McNulty… - Cancer research, 2009 - AACR
Elevated eukaryotic translation initiation factor 4E (eIF4E) function induces malignancy in
experimental models by selectively enhancing translation of key malignancy-related mRNAs (c-…
experimental models by selectively enhancing translation of key malignancy-related mRNAs (c-…
Therapeutic inhibition of MAP kinase interacting kinase blocks eukaryotic initiation factor 4E phosphorylation and suppresses outgrowth of experimental lung …
BW Konicek, JR Stephens, AM McNulty, N Robichaud… - Cancer research, 2011 - AACR
Activation of the translation initiation factor 4E (eIF4E) promotes malignant transformation and
metastasis. Signaling through the AKT-mTOR pathway activates eIF4E by phosphorylating …
metastasis. Signaling through the AKT-mTOR pathway activates eIF4E by phosphorylating …
[HTML][HTML] Preclinical characterization of abemaciclib in hormone receptor positive breast cancer
…, C Baquero, B Alvarez, J Amat, AM McNulty… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Abemaciclib is an ATP-competitive, reversible kinase inhibitor selective for CDK4 and
CDK6 that has shown antitumor activity as a single agent in hormone receptor positive (HR+) …
CDK6 that has shown antitumor activity as a single agent in hormone receptor positive (HR+) …
Design and synthesis of novel monocyclic β-lactam inhibitors of prostate specific antigen
…, GW Becker, RB Hermann, AM McNulty… - Bioorganic & Medicinal …, 1997 - Elsevier
A novel series of monocyclic β-lactam analogues was designed using a homology derived
model of prostate specific antigen (PSA) and by application of a multiple copy simultaneous …
model of prostate specific antigen (PSA) and by application of a multiple copy simultaneous …
Design, synthesis, and proposed active site binding analysis of monocyclic 2-azetidinone inhibitors of prostate specific antigen
…, TJ Howe, W McCoull, AM McNulty… - Journal of medicinal …, 2001 - ACS Publications
A homology derived molecular model of prostate specific antigen (PSA) was created and
refined. The active site region was investigated for specific interacting functionality and a …
refined. The active site region was investigated for specific interacting functionality and a …
Growth regulation of prostatic stromal cells by prostate-specific antigen
…, C Teater, P Cohen, AM McNulty… - Journal of the …, 1999 - academic.oup.com
BACKGROUND: Prostate-specific antigen (PSA) is a serine protease that can cleave insulin-like
growth factor-binding protein-3 (IGFBP3), thereby decreasing its affinity for insulin-like …
growth factor-binding protein-3 (IGFBP3), thereby decreasing its affinity for insulin-like …