BCG immunotherapy of bladder cancer: 20 years on

AB Alexandroff, AM Jackson, MA O'Donnell, K James - The Lancet, 1999 - thelancet.com
Review this adequately. What is certain is that BCG is not effective for muscle-invasive
disease, or for tumours that lie out of direct contact with BCG such as those deep within the …

Mechanisms of action of intravesical bacille Calmette-Guerin: local immune mechanisms

…, SJ Hawkyard, AB Alexandroff… - Clinical infectious …, 2000 - academic.oup.com
The local immune response to mycobacteria is complex, but mycobacterial antigen presentation
by phagocytes to T helper cells is the pivotal interaction. Bacille Calmette-Guérin (BCG) …

Role for CD40–CD40 ligand interactions in the immune response to solid tumours

AB Alexandroff, AM Jackson, T Paterson, JL Haley… - Molecular …, 2000 - Elsevier
CD40-mediated interactions play an important role in the response to infections, transplantation,
and cancer by affecting the development, activation, proliferation and differentiation of a …

Recent advances in bacillus Calmette–Guerin immunotherapy in bladder cancer

AB Alexandroff, S Nicholson, PM Patel… - Immunotherapy, 2010 - Future Medicine
The concept of using Mycobacterium for cancer treatment goes back to the 19th Century.
Today, bacillus Calmette–Guerin (BCG) vaccine is a well-established treatment for human …

Alitretinoin for the treatment of severe chronic hand eczema

T King, J McKenna, AB Alexandroff - Patient Preference and …, 2014 - Taylor & Francis
Chronic hand eczema is a common and often debilitating condition. Alitretinoin, a 9-cis-retinoic
acid and pan-retinoic acid agonist, is a new and effective systemic treatment for chronic …

Current dilemmas and controversies in allergic contact dermatitis to ophthalmic medications

ES Novitskaya, SJ Dean, JP Craig, AB Alexandroff - Clinics in dermatology, 2011 - Elsevier
Identifying contact allergens in ophthalmic medications can be a challenging and daunting
experience. We summarize data on topical ophthalmic medications with the potential to …

Tumour immunology: false hopes—new horizons?

AB Alexandroff, RA Robins, A Murray, K James - Immunology today, 1998 - cell.com
For the past 100 years, tumour immunology has witnessed peaks and troughs of interest. A
recent meeting1The 5th Annual Congress of the British Society for Immunology was held at …

Autocrine regulation of ICAM-1 expression on bladder cancer cell lines: evidence for the role of IL-1α

AB Alexandroff, AM Jackson, K Esuvaranathan… - Immunology letters, 1994 - Elsevier
We have studied the autocrine regulation of essential expression of the intercellular
adhesion molecule-1 (ICAM-1) on 8 transitional cell carcinoma (TCC) cell lines (histopathological …

Long-term safety of biologics in the treatment of psoriasis

…, H Coope, J McKenna, AB Alexandroff - Psoriasis: Targets and …, 2013 - Taylor & Francis
Biologics are novel and important agents in the treatment of severe psoriasis. These agents
block specific molecular steps in the inflammatory cascade, thereby reducing activation and …

Bacillus-calmette-guerin (bcg) organisms directly alter the growth of bladder-tumor cells

…, AB ALEXANDROFF… - International …, 1994 - spandidos-publications.com
Studies in recent years have shown various effects of bacillus Calmette Guerin organisms
on the human immune system. In the present study, the direct effects of bacillus Calmette …