Background Because pragmatic trials are performed to determine if an intervention can improve
current practice, they often have a control group receiving ‘usual care’. The behaviour of …

Objective To interpret questionnaire scores, clinicians and researchers need to know what
change in score reflects a meaningful change in the condition of an individual patient, and …

Background The outcome measures most frequently used in studies on the effectiveness of
migraine treatment are whether the patient is free of pain, nausea, and free of photophobia/…

Background/objectives Low vitamin B12 and folate levels in community-dwelling older people
are usually corrected with supplements. However, the effect of this supplementation on …

Background: Migraine is a common, disabling headache disorder that leads to lost quality of
life and productivity. We investigated whether a proactive approach to patients with migraine…

Background: The number of migraine patients eligible for preventive treatment is considerably
higher than the number of patients actually using it. This study explores reasons for this …

Background Clinical trials on the prophylactic effect of propranolol and metoprolol for migraine
show that starting this medication leads to a decrease in the use of attack medication of …

To propose minimal important differences (MID) for the Migraine-Specific Quality of Life
Questionnaire version 2.1 (MSQ v2.1). To our knowledge (to date), no published MID values …

Aims In this study, we tested the validity of the Severity of Dependence Scale in detecting
dependence behaviours in patients with chronic migraine and medication overuse (CM + MO) …

Background Pernicious anaemia is undeniably associated with vitamin B12 deficiency, but
the association between subnormal vitamin B12 concentrations and anaemia in older people …